Specific functional effects of memantine treatment in patients with moderate to severe Alzheimer’s...
Sponsored Links
This presentation is the property of its rightful owner.
1 / 9

Doody R., Wirth Y., Schmitt F. and Möbius H.J. Dement Geriatr Cogn Disord 2004; 18:227 – 232 PowerPoint PPT Presentation


  • 112 Views
  • Uploaded on
  • Presentation posted in: General

Specific functional effects of memantine treatment in patients with moderate to severe Alzheimer’s disease. Doody R., Wirth Y., Schmitt F. and Möbius H.J. Dement Geriatr Cogn Disord 2004; 18:227 – 232. Baseline Characteristics. US StudyEU Study. MemantinePlaceboMemantinePlacebo

Download Presentation

Doody R., Wirth Y., Schmitt F. and Möbius H.J. Dement Geriatr Cogn Disord 2004; 18:227 – 232

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Specific functional effects of memantine treatment in patients with moderate to severe Alzheimer’s disease

Doody R., Wirth Y., Schmitt F. and Möbius H.J.

Dement Geriatr Cogn Disord 2004; 18:227–232


Baseline Characteristics

US StudyEU Study

MemantinePlaceboMemantinePlacebo

(N = 126)(N = 126)(N = 41)(N = 38)

Patients completing study, N (%)97 (77%)84 (67%)39 (95%)37 (97%)

Gender, femaleN (%)91 (72%)79 (63%)29 (71%)24 (63%)

Mean age (years)75.976.373.474.9

Race, CaucasianN (%)112 (89%)115 (91%)41 (100%)38 (100%)

Mean MMSEscore at baseline7.78.16.76.8

Residential status outpatients nursing home patients

Doody et al., Dement Geriatr Cogn Disord 2004


Beneficial Effects of Memantine on Function in AD Outpatients (I)

Mean change (±SEM) from baseline in ADCS-ADL19 item scores (US trial)

Pay attention to conversation*

Use a telephone#

Watch television

Get around outside of his/her home#

Dispose of garbage or litter*

Clear dishes from table after meal*

Find his/her personal belongings

Memantine

Placebo

-0.8

-0.6

-0.4

-0.2

0

0.2

0.4

Decline

Improvement

* p < 0.05, # p < 0.10

Doody et al., Dement Geriatr Cogn Disord 2004


Beneficial Effects of Memantine on Function in AD Outpatients (II)

Mean change (±SEM) from baseline in ADCS-ADL19 item scores

Turn light off without help

Turn light on without help

Turn off faucet without help

Run water from a faucet to wash

Obtain a hot or cold beverage

Left on his/her own

Memantine

Placebo

-0.8

-0.6

-0.4

-0.2

0

0.2

0.4

Decline

Improvement

Doody et al., Dement Geriatr Cogn Disord 2004


Beneficial Effects of Memantine on Function in AD Outpatients (III)

Mean change (±SEM) from baseline in ADCS-ADL19 item scores (US trial)

Physically getting dressed

Grooming

Bathing

Toiletting

Walking

Eating

Memantine

Placebo

-0.8

-0.6

-0.4

-0.2

0

0.2

0.4

Decline

Improvement

Doody et al., Dement Geriatr Cogn Disord 2004


Consistent Beneficial Effects on Function in AD Outpatients

Mean change (±SEM) from baseline in ADCS-ADL19 item scores

Pay attention to conversation*

Turn light off

Dispose of garbage*

Turn faucet off

Get around outside#

Use a telephone#

Run water from a faucet

Walking

Watch television

Clear dishes from table*

Find personal belongings

Turn light on

Toiletting

Eating

Grooming

Left on his/her own

Bathing

Obtain a beverage

Getting dressed

Memantine

Placebo

-0.8

-0.6

-0.4

-0.2

0

0.2

0.4

Decline

Improvement

* p < 0.05, # p < 0.10

Doody et al., Dement Geriatr Cogn Disord 2004


Beneficial Effects of Memantine on Function in Nursing Home Patients (I)

Mean change (±SEM) from baseline in G2-scale scores (EU study)

Mobility in bed

Ability to stand up*

Ability to move*

Ability to wash

Ability to bath/take a shower

Ability to dress*

Ability to eat*

Ability to drink*

Use of toilet*

Memantine

Placebo

0.2

0

-0.2

-0.4

-0.6

-0.8

Improvement

* p < 0.05

Doody et al., Dement Geriatr Cogn Disord 2004


Beneficial Effects of Memantine on Function in Nursing Home Patients (II)

Mean change (±SEM) from baseline in G2-scale scores (EU study)

Understanding

Communicates

Orientation

Recognition of persons

Group activities#

Hobbies#

Sleeping-waking rhythm

Behaviour

Memantine

Placebo

0.2

0

-0.2

-0.4

-0.6

-0.8

Improvement

# p < 0.10

Doody et al., Dement Geriatr Cogn Disord 2004


Summary

  • The ADL single item analyses consistently confirm that memantine monotherapy provides significant benefits on functional abilities for patients with moderate to severe Alzheimer’s disease

  • The benefits have been demonstrated in both outpatients (Reisberg et al., 2003) and nursing home patients (Winblad and Poritis, 1999)

  • The positive effects of memantine on function may not only have a positive impact on the patient but also on the caregiver and healthcare resource utilization


  • Login