Major Interests: MicroRNA and viruses, in Latency and Infection, e.g. cytomegalovirus

1. יונת שמר, המעבדה לנגיפים מרכז רפואי אוניברסיטאי סורוקה הפקולטה למדעי הבריאות, BGUתקשורת: 0526250504, מייל yonat@bgu.ac.il • Major Interests: • MicroRNA and viruses, in Latency and Infection, e.g. cytomegalovirus • Molecular markers for PATHOGEN infections (host and pathogen) • Deep sequencing screen • Respiratory infections in the hospital and the community • HPV prevalence in the community

3. MicroRNAs are small 22-24 RNAs, recently discovered, that participate in post-transcription regulation. We study miRNA genes encoded by viruses and the effect of viral infection on host encoded microRNAs Infected cells Small RNA Deep sequence HCMV Human ncRNAs HCMV ncRNAs ncRNAs signatures of infection Small RNA sequencing / Noam Shomron

4. Predictions and analysis of genes targeted by viral miRNAs

5. 16,837,317 reads of short RNA in DS • 1,015,588 (6%) match the hCMV genome • 812,477 (80%) map to the known hCMVmiRNAs • 38,678 (4%) map to NEW miRNAs • 7903 (0.7%) map to moRs. 23% 200,000 150,000 13.7% 12.7% 10.6% 100,000 10.5% 9.3% 6% 50,000 3.3% 4% 2.6% 0.8% 5,000 Read Count 2,500 UL22A-3p UL36-5p US25-1-5p US25-2-5p US25-2-3p UL22A-5p US5-2-3p UL112-3p US29-5p US33-5p US5-1-3p UL36-3p US25-1-3p US33-3p UL112-5p US4-5p US4-3p US22-5p US29-3p US5-2-5p UL59-5p US22-3p US5-1-5p UL69-5p UL70-5p UL70-3p UL148D 1,000 800 600 400 200 0

6. תודה על ההקשבה