Erythritol (Erythritol) A new All-Natural and Noncaloric Bulk Sweetener

1. Erythritol(Erythritol)A new All-Natural and Noncaloric Bulk Sweetener

2. CH2OH H C OH H C OH CH2OH 1 , 2 , 3 , 4 - b u t a n e t e t r o l m e s o - e r y t h r i t o l Basic Characteristics of Erythritol • white crystalline powder • sweetness is 60 to 70% relative to sucrose • non-hygroscopic • medium solubility, solutions have a very low viscosity • crystallises very easy and fast • high freezing point depression and boiling point elevation • high negative heat of solution

3. Chemical/Physical Properties of Erythritol • High stability • high stability in dry state and aqueous solutions • storage stability • high heat and acid/alkaline stability • Inert material: Erythritol is not a reactive compound • Erythritol is produced with different • particle size distribution / granulometry • max. 20% <200 m • max. 5% < 250 m • flowability

4. Chemical/Physical Properties of Erythritol and other Bulk Sweeteners

5. Erythritol: An All-Natural Sweetener • Erythritol occurs naturally in many fruits, mushrooms, and in popular fermented foods such as soy sauce, miso, cheese, wine, beer and sake • Manufacturing process: • separation of starch from non-GM corn • enzymatic hydrolysis of starch into glucose • fermentation of glucose by a safe and suitable non-GM microorganism Moniliella Pollinis (a yeast-like fungus) • purification, ultrafiltration, crystallisation and drying • white crystals, purity >99.5%

6. Nutrition & Health Benefits

7. Metabolic Profile Erythritolcompared with Other Polyols

8. Spread in Regulatory Caloric Value (Japan, USA, ANZ, Canada, EC) Erythritol Xylitol Lactitol Isomalt Maltitol Mannitol Sorbitol 0.0 1.0 2.0 3.0 4.0 Caloric Value (kcal/g) * Approval pending in EC Erythritol has the Lowest Caloric Value of all Polyols

9. 0.90 Source: Oku et al 0.80 0.80 0.68 0.70 0.60 0.50 Maximum bolus dose not causing laxation (g/kg BW) 0.40 0.30 0.30 0.24 0.20 0.10 0.00 Sorbitol Maltitol Lactose Erythritol Erythritol has the Highest Digestive Tolerance of all Polyols Digestive tolerance under most severe conditions: • Maximum single bolus dose not causing laxation (female adults) • Consumed as a liquid or jelly, on an empty stomach, within 10 minutes • Clinical studies show that Erythritol has a digestive tolerance which is • 3 to 4 times better compared to sorbitol and mannitol • 2 to 3 times better compared to xylitol, lactitol, maltitol • and isomalt

10. Digestive Tolerance under Anticipated Conditions of Use • Under normal conditions of use, the digestive tolerance is far greater: • spread over the day • variety of food products • adaptation • Erythritol does not cause undesired gastrointestinal effects under its intended conditions of use: • based on clinical studies in which erythritol was administered with food and beverages at daily doses up to 1 g/kg bw, a laxation threshold cannot be defined

11. Insulinaemic response Glycemic response 6 30 25 5 20 15 Plasma Insulin level mUI/l Plasma Glucose Level mmol/l 4 10 5 0 3 -0.5 0 0.5 1 1.5 2 2.5 3 -0.5 0 0.5 1 1.5 2 2.5 3 Time after ingestion (h) Time after ingestion (h) Erythritol is Suitable for People with Diabetes Average glycaemic and insulinaemic plasma responses after a 1g/kg bodyweight single oral intake of erythritol by 6 healthy human volunteers Source: Bornet et al

12. Erythritol is ToothfriendlyIn Vivo Plaque-pH Test Example of a plaque pH curve of interdental plaque in one volunteer during and for 30 min after consumption of a Erythritol-based lozenge. A 0.3 mol/l (10%) sucrose rinse for two minutes was used as positive control. PC = Paraffin Chewing Source: Dental Institute Zurich

13. Anti-Cariogenic Activity of Erythritol • Erythritolis capable to (partly) inhibit oral bacteria in their ability to ferment certain sugars • For example, sugar-free toothfriendly milk chocolate can be made with normal lactose-containing milk powder when Erythritolis used as the sole bulk sweetener

14. Sweet Sucrose Erythritol Sweet persistence Acid Both at 10% SEV Bitter aftertaste Bitter Astringent aftertaste Burnt sugar Smoothness Caramel Drying Body Erythritol has a Clean Sweet TasteLike Sugar Source: LFRA

15. Erythritol inNon-Caloric Tabletop Sweeteners • Particularly important for tabletop, Erythritol offers: • crystalline structure • same density as sucrose • non-hygroscopicity • excellent flowability • stability as carrier for intense sweeteners • Erythritol improves taste quality of the finished application to which it is added (tea, coffee, cereals, yoghurt, …)

16. Key Takeaways • Erythritol has unique nutrition and health benefits: • all-natural sugar replacer • non-caloric (<0.2 kcal/g) • highest digestive tolerance of all polyols • non-cariogenic, in some formulations even anti-cariogenic • suitable for diabetics • Erythritol has a clean sweet taste and provides excellent synergies with intense sweeteners by improving mouthfeel and taste quality • Erythritol fits extremely well functional food concepts • Erythritol exhibits technical properties allowing development of truly new and healthy food concepts ErythritolOFFERS MAJOR ADVANTAGES TO FOOD & DRINK AS WELL AS PHARMACEUTICAL MANUFACTURERS