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UTMB CTSA recompetition strategies. No FOA-what we know…. IOM report stresses… Build on unique strengths Innovate and evaluate what we do Education of a broadworkforce will continue to be a focus We must show participation and value to the national consortium NCATS Directorship says…

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Utmb ctsa recompetition strategies

UTMB CTSArecompetition strategies


No foa what we know
No FOA-what we know…

  • IOM report stresses…

  • Build on unique strengths

  • Innovate and evaluate what we do

  • Education of a broadworkforce will continue to be a focus

  • We must show participation and value to the national consortium

  • NCATS Directorship says…

  • TR is a team activity

  • Partner/leverage

  • Show value to communities, stakeholders, NIH ICs


Strategies
Strategies

  • UTMB-centric

    • Build on Translational Teams to leverage our unique institutional strengths and innovation in clinical research

    • Grow clinical trials

    • Strengthen PCOR

  • TRCC-centric

    • Disseminate CI&EP throughout the TRCC

    • TRCC KL2 Network

    • Responsible Conduct for Research?

    • Community engagement

    • Clinical trial network

  • National consortium-centric

    • SGC3 Team Science Initiative

    • National Mentoring Research Network


Innovation in educational activities
Innovation in educational activities

  • What we have implemented:

  • Clinical science PhD in medical bioinformatics-

  • Human Pathophysiology and Translational Medicine

  • Certificate Programs

  • Entrepreneurship, bioventure- (now being launched at the TMC)

  • Systems biology

  • PCOR

  • Modules in translational team management

  • Collaborative Innovation and Entrepreneurship Program (CI&EP)


Alignment of Training and Education Activities

with MTTs

Collaborating Investigators

Team Workshops

Team Leadership

Council

Mentoring

Established Investigator

Clinical Science Program

Translational

Research

Scholars

Research

specialties

Assistant

Professors

Principal

Investigator

Project

Manager

MTT

roles

Human

Subjects

Graduate

Students

Health Care

Trainees

(MD, PT,RN)

Research

specialties

Human

Pathophysiology

And

Translational

Medicine

Courses

Tools and Techniques

Strategic core

Translational

Research

Track

BT Ameredes, in preparation


The broad aim of the CI&EP initiative is to accelerate the translation of innovative technologies and processes into successful commercial ventures.

The initiative seeks to spur innovation through educational training partnerships with UT Austin-McCombs School of Business (UT), NASA Johnson Space Center (NASA JSC), and University of Houston, Clear Lake (UHCL).

Christina M. Cestone, PhD


Ci ep implementation schedule 2012 2013
CI&EP Implementation Schedule (2012-2013) Entrepreneurial Program (CI&EP)

*Maximum enrollment 25.

Christina M. Cestone, PhD


Course enrollment metrics
Course Enrollment Metrics Entrepreneurial Program (CI&EP)

Christina M. Cestone, PhD


Participants
Participants Entrepreneurial Program (CI&EP)

N=33 (~30% of enrolled)

71% held terminal degrees,

  • 41% PhDs (Research Scientists, Postdocs)

  • 17.6% MDs (Faculty and Research)

  • 11.8% MD/PhDs

  • Remaining trainees pursuing advanced degrees or staff.

  • 65% between 25 and 35 Y/O

  • Christina M. Cestone, PhD


    Key findings
    Key Findings Entrepreneurial Program (CI&EP)

    • Participants reported the Management of Technology course influenced, to a large or very large extent, their perceived ability to commercialize scientific discoveries.

    • Participants reported learning the business terminology necessary to lead cross-disciplinary scientific collaborations.

    • Participants reported immediate utility of Business Innovation course concepts.

    Christina M. Cestone, PhD


    Leveraging the trcc
    Leveraging the TRCC Entrepreneurial Program (CI&EP)

    This meeting’s outcomes in clinical research networks- Conduct multi-site clinical trial throughout the TRCC- would be extremely powerful.

    Several trials under development:

    • N. Abate CER on NASH associated with type 2 DM in hispanics

    • D. Herndon, DOD-funded multi-site trial in burns treatment

      Infrastructure provided by CTSA

  • Harmonization of processes (Master Trial Agreements, etc.)

  • Data management/Data coordinating center(s)

  • Inventory of clinical trialists

  • Link Cores- MOU-


  • Leveraging the trcc1
    Leveraging the TRCC Entrepreneurial Program (CI&EP)

    • Education

    • Disseminate CI&EP throughout the TRCC- bioventures now hosted at the TMC

    • TRCC KL2 Network

    • Responsible Conduct for Research?

    • Mentoring- mentoring network throughout the TRCC- perhaps contribute to CTSA-National Research Mentoring Network (NRMN, PIs-C. Bylington, Univ. Utah, K. Freund, Tufts Univ.)

    • We need a mechanism for keeping track of working groups- Executive committee?


    National agenda sgc3 team science affinity network
    National Agenda- SGC3 Team Science affinity network- Entrepreneurial Program (CI&EP)

    Goals are:

    • To produce an integrated development/education/evaluation group;

    • Share and disseminate evidence-based practices;

    • Conduct and evaluate evidence-based research interventions across CTSA sites. For example:

      • collaboration readiness/needs assessment,

      • collaboration skills training,

      • meeting management training

      • evaluation


    Mtts to promote translational research
    MTTs to promote translational research Entrepreneurial Program (CI&EP)

    • How CTSAs can support teams:

    • Calhoun, WJ, Wooten, K, Bhavnani, S, Anderson, KE, Freeman, J, and Brasier,AR. The CTSA as an Exemplar Framework for Developing Multidisciplinary Translational Teams. ClinTransl Sci. 6(1): 60-71, 2013.

    • Interventions to improve team leadership and functions

    • Bhavnani, S.K., Farroni, J. S., Crowder, J., McKinney, B., Pillai, R., Calhoun W. J., Rose, R.M. Carter, M.A. The Role of Method Intuition in Translational Ethics. Proceedings of AMIA Summit on Translational Bioinformatics (2012).

    • We’ve refined our MTT review process for assessing collaboration readiness, supported 16 teams with CTSA-ascribable grant outcomes and publications

    • We’ve demonstrated the transformative impact of the CTSA on culture

    • Kotarba, J, Symbolic Interaction and Applied Social Research: A Focus on Translational Science Research, Symbolic Interaction , Volume 37, Number 2 (2014)


    Evaluating outcomes of mtts
    Evaluating outcomes of MTTs Entrepreneurial Program (CI&EP)

    Mixed methods assessment of team project outcomes and longitudinal assessment of development

    • Wooten, KC, Rose, RM, Ostir, GV, Calhoun, WJ, Ameredes, B.T. and Brasier, AR. Assessing and Evaluating Multidisciplinary Translational Teams: A Case Illustration of a Mixed Methods Approach and an Integrative Model. Evaluation in the Health Sciences, 2014.


    Current status
    Current status Entrepreneurial Program (CI&EP)

    • Assembled and met with steering committee (H. Falk-Krzesinski, Elsevier;

    • K. Hall, NCI; B. Spring, NWU; D Ilgen, Univ. MI; E. Salas, U. of Fla: B. Trochim, Columbia;

    • M. Bennett, NIH; J. Keyton, NCU; D. Rubio, UPitt).

      • The committee endorsed our research-oriented plan and will work with

      • us to coordinate with ongoing IOM/NSF initiatives.

    • 2 organizational teleconferences in July and August and one organizational

    • meeting

    • Currently, 27 participants from 12 distinct CTSA sites:

    • 12 in education

    • 16 in team development

    • 12 in evaluation

    • Immediate goals:

    • Develop uniform ontologies

    • Identify major needs in team science in participating CTSA sites

    • Prioritize, deploy and evaluate team science educational activities


    Ctsa national research mentoring network
    CTSA National Research Mentoring Network Entrepreneurial Program (CI&EP)

    Goal is to increase diversity of the biomedical workforce (URM, LES).

    One network will be funded in 2014 through the NIH common fund. It is expected that

    the network will be closely integrated with the CTSA, CC-CHOC, ACTS,

    and BUILD networks and others.

    This summer, P20 planning grants were awarded to 6 sites,

    one (Blyington and Freud) supported by41 CTSA PIs. A planning meeting was held in

    Philadelphia last week.

    Although the FOA not released, the goal is to develop, disseminate and evaluate

    evidence-based strategies for promoting URM involvement in the biomedical workforce.

    The TRCC could be a meaningful contributor to the NRMN


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