A laser afternoon introduction
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A Laser Afternoon: Introduction. Ken Peach Particle Therapy Cancer Research Institute (Oxford Martin School) & John Adams Institute for Accelerator Science, University of Oxford Imperial College December 13 th 2012.

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A laser afternoon introduction

A Laser Afternoon:Introduction

Ken Peach

Particle Therapy Cancer Research Institute (Oxford Martin School)

&

John Adams Institute for Accelerator Science, University of Oxford

Imperial College

December 13th 2012

The tax mans taken all my dough,And left me in my stately home,Lazing on a sunny afternoon.

Ray Davis (The Kinks) “Sunny Afternoon”


Outline

Outline

  • What is needed?

  • Where could we help?

  • What should we do?


What is needed

Therapy

Radiobiology

What is needed?


Depth dose curves photon and proton

Depth Dose curves – photon and proton

100

tumour

80

SOBP

Dose (%)

60

MV x-rays

40

Pristine peak

20

50

100

150

Depth (mm)


Relative biological effectiveness rbe linear energy transfer let

Relative Biological Effectiveness (RBE) & Linear Energy Transfer (LET)

  • LET is related to dE/dx (Bethe Bloch)

    but is the energy transferred to the medium,

    not the energy lost by the particle


A laser afternoon introduction

RBE

  • The recommended value of RBE for protons is 1.1


Photon proton irradiation

photon & proton irradiation

  • Averaged survival fractions over 3 repeated experiments.

Dose (Gy)

After AI Nagano (PTCRi, private communication)

PTCRi Meeting


Therapy parameters energy

Therapy Parameters: Energy

30 cm

thickness of human body

Radiography

300 MeV (p)

550 MeV/u (C)


Summary of therapy requirements

Summary of Therapy Requirements


Summary of radiobiology desiderata

Summary of Radiobiology Desiderata

  • Energy reach

    • Protons, helium, lithium, carbon, oxygen

      • to at least 10-100 mm

      • 20-120 MeV (p)

      • 60-220 MeV/u (C)

        • Study mouse models in and away from the Bragg peak

      • Cell studies

        • Probably down to a few MeV/u

  • Flux

    • From single particle to >2 Gy/min

  • Field

    • Micro- or Nano-beam to 100 x 100 mm2


Requirements for both

Requirements for both

  • Desired energy

    • energy within 1% of specification

  • Small distribution of energy

    • s ~1%

  • Desired flux

    • High flux – 1%

    • Single particle

  • Precise transverse position

    • <0.5mm

    • ~microns (single particle)


C f characteristics of a leir radiobiology facility

c.f. characteristics of a LEIR Radiobiology facility

  • Energy reach

    • Fully stripped 12C or 16O up to 240 MeV/u

    • 430 MeV/u (magnet limit) with new PS

  • Possible beam lines

    • Horizontal (full energy)

    • Vertical (limited energy ~100 MeV/u)

  • Large Hall

    • Currently used for storage

    • Space for radio biology laboratories

  • Status: under consideration

    • Feasability study in progress

    • Funding?

      • EU? Funding Agencies? Special budget?


Where could we help

Where could we help?


A compact laser plasma ion source

A Compact Laser-Plasma Ion Source

  • For radiobiology (see above)

    • Rapid change of ion species

  • “Small” footprint

    • (shielding!)

      • (few square metres)

  • Low(ish) cost

    • Not defined, but “less than millions”

  • For therapy

    • Use and an injector to a post-accelerator

      • FFAG-like (accelerate a spectrum)

  • Later (20-30) years?

    • Full therapy system


Summary and conclusion

Develop a simple plasma-driven ion source?

reliable, reproducible, flexible, “cheap”

Radiobiology

easier than therapy as a first phase

Therapy injector

useful as a second phase

Therapy

eventually aim for a compact CPT facility

Is there a possible funding source?

Summary and conclusion


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