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Fruits and Vegetables and Lung Cancer Publication

Fruits and Vegetables and Lung Cancer Publication. Smith-Warner, S. A., et al. Fruits, vegetables and lung cancer: a pooled analysis of cohort studies. International Journal of Cancer. 2003; 285:769-776. Cohort Studies Included in the Pooled Analysis of Fruits, Vegetables and Lung Cancer.

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Fruits and Vegetables and Lung Cancer Publication

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  1. Fruits and Vegetables and Lung Cancer Publication Smith-Warner, S. A., et al. Fruits, vegetables and lung cancer: a pooled analysis of cohort studies. International Journal of Cancer. 2003; 285:769-776.

  2. Cohort Studies Included in the Pooled Analysis of Fruits, Vegetables and Lung Cancer Nurses’ Health Study Netherlands Cohort Study Canadian National Breast Screening Study Health Professionals Follow-up Study New York State Cohort Alpha-Tocopherol Beta-Carotene Cancer Prevention Study Adventist Health Study Total = 430,281 # cases = 3,206 Iowa Women’s Health Study Smith-Warner, et al. 2003

  3. Cohort Studies in the Pooled Analysis of Fruits and Vegetables and Lung Cancer Study Baseline # of Cohort Cases Adventist Health (W) 17,990 20 Adventist Health (M) 12,526 31 ATBC 6,771 298 Canadian National 56,837 149 Health Professionals 44,350 244 Iowa Women’s 33,828 433 Netherlands Cohort (W) 62,412 131 Netherlands Cohort (M) 58,279 843 New York State (W) 21,045 130 New York State (M) 27,936 392 Nurses’ Health (a) 88,307 156 Nurses’ Health (b) 68,307 379 Smith-Warner, et al 2003

  4. Median Fruit and Vegetable Intakes (g/d) Study Total Total Fruits Vegetables Adventist Health (W) 354 162 Adventist Health (M) 310 151 ATBC 121 94 Canadian National 314 221 Health Professionals 300 293 Iowa Women’s 339 195 Netherlands Cohort (W) 207 164 Netherlands Cohort (M) 155 157 New York State (W) 290 188 New York State (M) 258 186 Nurses’ Health (a) 272 150 Nurses’ Health (b) 329 259 Smith-Warner, et al 2003

  5. Fruits and Vegetables and Lung Cancer: Pooled Multivariate RR by Quintile Quintile Total Fruits Total Veg. RR (95% CI) RR (95% CI) 1 1.00 1.00 2 0.82 (0.73-0.91) 0.94 (0.83-1.05) 3 0.78 (0.67-0.90) 0.87 (0.76-0.99) 4 0.83 (0.74-0.94) 0.90 (0.80-1.02) 5 0.77 (0.67-0.87) 0.88 (0.78-1.00) p for trend <0.001 0.12 p for het. for Q5 0.56 0.76 Smith-Warner, et al 2003

  6. AHS_f AHS_m ATBC CNBSS HPFS IWHS NLCS_f NLCS_m NYS_f NYS_m NHS(a) NHS(b) Combined .1 .5 1 5 10 Relative Risk Study-Specific Multivariate Relative Risks of Lung Cancer and Fruit Intake (Quintile 5 vs. 1) Smith-Warner et al, 2003

  7. AHS_f AHS_m ATBC CNBSS HPFS IWHS NLCS_f NLCS_m NYS_f NYS_m NHS(a) NHS(b) .1 .5 1 5 10 Study-Specific Multivariate Relative Risks of Lung Cancer and Vegetable Intake (Quintile 5 vs. 1) Combined Relative Risk Smith-Warner et al, 2003

  8. Pooled Multivariate Relative Risk of Lung Cancer and Total Fruit Intake 1.4 1.2 1.0 0.8 Relative Risk 0.6 # cases: 799 765 581 417 444 0.4 0.2 0.0 <100 >400 100 - <200 200 - <300 300 - <400 Intake (g/day) Smith-Warner et al, 2003

  9. Pooled Multivariate Relative Risk of Lung Cancer and Total Vegetable Intake 1.4 1.2 1.0 Relative Risk 0.8 0.6 # cases: 631 1222 657 282 214 0.4 0.2 0.0 <100 >400 300 - <400 100 - <200 200 - <300 Intake (g/day)

  10. Pooled Multivariate Relative Risks of Lung Cancer and Specific Foods Food RR (95% CI) >1/2 vs. 0 serving/d Apples, pears 0.80 (0.68-0.94) Bananas 1.04 (0.89-1.22) Oranges, tangerines 0.74 (0.58-0.95) Orange/grapefruit juice 0.82 (0.71-0.94) Carrots 0.91 (0.75-1.11) Tomatoes 0.83 (0.67-1.03) Smith-Warner, et al 2003

  11. Total Fruits and Lung Cancer: Pooled Multivariate RR by Smoking Status Quartile Never Past Current n=259 n=981 n=1915 1 1.00 1.00 1.00 2 0.72 0.85 0.83 3 0.78 0.85 0.85 4 0.59 0.85 0.82 (0.34-1.04) (0.69-1.05) (0.68-0.99) p for trend 0.16 0.43 0.02 p for het. due to smoking status for Q4 = 0.39 Smith-Warner, et al 2003

  12. Total Vegetables and Lung Cancer: Pooled Multivariate RR by Smoking Status Quartile Never Past Current n=259 n=981 n=1915 1 1.00 1.00 1.00 2 0.94 0.97 0.84 3 1.02 0.93 0.87 4 0.90 0.97 0.86 (0.58-1.40) (0.76-1.24) (0.74-1.00) p for trend 0.75 0.83 0.14 p for het. due to smoking status for Q4 = 0.72 Smith-Warner, et al 2003

  13. Total Fruits and Lung Cancer: Pooled Multivariate RR by Cell Type Quartile Adeno. Small Squamous n=956 n=538 n=901 1 1.00 1.00 1.00 2 0.84 0.78 0.70 3 0.84 0.92 0.74 4 0.84 0.93 0.75 (0.71-0.99) (0.71-1.23) (0.59-0.96) p for trend 0.10 0.71 0.01 p for common effects by cell type for Q4 = 0.51 Smith-Warner, et al 2003

  14. Total Vegetables and Lung Cancer: Pooled Multivariate RR by Cell Type Quartile Adeno. Small Squamous n=956 n=901 n=659 1 1.00 1.00 1.00 2 0.88 1.04 0.86 3 0.97 1.07 0.86 4 0.91 0.98 0.94 (0.75-1.11) (0.77-1.26) (0.78-1.12) p for trend 0.53 0.92 0.84 p for common effects by cell type for Q4 = 0.63 Smith-Warner, et al 2003

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