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G3 Workshop North America Leadership Conference March 3, 2006.

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G3 Workshop

North America

Leadership Conference

March 3, 2006

This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.


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Mark R. Bartlett Ph.D.

Sr. Director, Pharmanex New Product Development


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Science &Tradition


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MSNBC.com

Spartan diet may slow agingNIH launches study to test practicality

By Rob Stein

The Washington Post

As the rest of the nation has been supersizing, a small cadre of Americans such as Francesca Skelton have been radically downsizing their diets — not to slim down their physiques but to slow down the hands of time.

Skelton is an adherent to the theory that "caloric restriction" can hold back the aging process by fundamentally altering basic metabolic functions in ways that protect the body from decaying as quickly.

So for years, the District grandmother and others like her have been eating often radical diets carefully calibrated to slash calories they consume each day while still providing their bodies with the nutrients they need.


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Green Tea and Longevity

Green Tea

Consumption

(Cups/Day)

Prospective, 11-year cohort study of 8,552 subjects in Yoshimi, Japan, 1986-1997. From: H. Fujiki et al., Ann. N.Y.Acad.Sci., 928:274, 2001; used with author’s permission


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Aging Symptoms

Antioxidants Addresses the Root Cause of Aging:

DNA Damage

  • DNA (DeoxyriboNucleic Acid) is your genetic blueprint

  • DNA enables healthy cell renewal into old age



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Free Radical Sources

  • Environmental pollution (smog, ozone, NO2)

  • Radiation exposure:

    • sunlight (UV-light), X-rays, etc.

  • Smoking:

    • 10,000,000,000,000,000 free radicals/cigarette!

  • Eating and Breathing: metabolism in your mitochondria


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SOD

CAT

Mitochondria – The Energy Furnaces of the body

Free Radicals


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MSNBC.com

  • Starve Your Way to HealthIt works for mice and fruit flies, but can ultra-low-calorie diets extend the life of humans?

  • By Jerry Adler and Anne Underwood

  • Newsweek

  • Jan. 19 issue - If the world is divided into people who live to eat and those who eat to live, perhaps there ought to be a third category for Brian Delaney. At 5 feet 11 inches and 139 pounds, Delaney, 40, is really, really thin. Thin, and hungry. He limits his calories to 1,800 a day, in part by eating just two meals, except when he has a dinner date, in which case that's the only meal he eats. After 10 years on this regimen—actually, he started out at 1,400 calories a day, less than half of what the average American male consumes—he still experiences "the same pit in my stomach" every afternoon, but now finds it "easier to deal with." Especially when he thinks of all the diseases he's avoiding. If Brian Delaney is right, he may well have the last laugh on the rest of humanity ... sometime in the 22d century.


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Aging so far…

  • DNA damage

  • Cell membrane damage

  • Uncontrolled free radical leakage from Mitochondria

The most common link?Free Radicals


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Antioxidant Health Benefits

Journal of the American Medical Association

“… low levels of the antioxidant vitamins (vitamins A, E, and C) may increase risk for several chronic diseases. Most people do not consume an optimal amount of all vitamins by diet alone.”

“It appears prudent for all adults to take vitamin supplements.”

Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard UniversityJournal of the American Medical Association 2002; 287: 3127-3129


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3 years ago…Pharmanex began Searching the World for Superfruits

  • R&D evaluated hundreds of fruits for…

    • Extraordinary antioxidant power

      • Measurable (Scanner)

      • Protect cells, (DNA, Membranes)

      • Enhance internal antioxidant production


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Fruit Phytonutrients

  • At least 1,000 phytochemicals identified with cell protective effects

  • Very few (25) studied

  • Fruits and vegetables – more than meets the eye

  • We don’t eat enough fruits and vegetables


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Families of Antioxidants

  • Vitamin E: 8 natural forms


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Families of Antioxidants

  • Vitamin E: 8 natural forms

  • Vitamin C:


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Families of Antioxidants

  • Vitamin E: 8 natural forms

  • Vitamin C

  • (Metallo-enzyme cofactors)

    • Selenium, Zinc, Manganese, Copper

Zinc

Enzyme Protein


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Families of Antioxidants

  • Vitamin E: 8 natural forms

  • Vitamin C: 500 mg

  • (Metallo-enzyme cofactors)

    • Selenium, Zinc, Manganese

  • Flavonoids:

    • Catechins,

    • polyphenols etc


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Families of Antioxidants

  • Vitamin E: 8 natural forms

  • Vitamin C

  • (Metallo-enzyme cofactors)

    • Selenium, Zinc, Manganese

  • Flavonoids:

    • Catechins, polyphenols etc

  • Carotenoids:

    • Β-carotene, lutein, lycopene, α-carotene


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Your Antioxidant Network

More than just One…

  • Vitamin E: 8 natural forms

  • Vitamin C

  • Metallo-enzymes (cofactors)

    • SOD, Catalase, Glutathione per.

    • Selenium, Zn, Mn, Cu

  • Flavonoids:

    • Catechins, polyphenols etc

  • Carotenoids:

    • Β-carotene, lutein, lycopene, α-carotene


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Pharmanex Research Centerswere involved…

  • Provo R&D Center

  • Shanghai R&D Center

  • Beijing R&D Center


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years of searching

  • Almost all failed Selection criteria

  • All but Four (g+3) very special fruits


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3Pharmanex Research Centers

3 Years of Searching and R&D

  • Gâc fruit (Chinese Bitter Cucumber)

  • Chinese Lycium (Wolfberry)

  • Cili fruit

  • Siberian Pineapple (Seabuckthorn)

3 +1 Superfruits


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Gâc -“Fruit From Heaven”

  • Indigenous to Southern Asia

    Bangladesh, Burma, Cambodia, China, India, Japan, Laos, Malaysia, Philippines, Thailand, and Vietnam

  • Traditionally used internally and externally*

    Topical: wound healing

    Internally: eye health, and to promote growth in children*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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Antioxidants in Gâc Pulp

  • Extraordinarily rich in antioxidants, esp. lycopene, beta-carotene, vitamin E

  • Unique fatty acids → Lipocarotenes™

Pulp

(aril)

Fruit flesh

(mesocarp)

Seeds


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Gac Fruit Lycopene Content

70 x more

than tomatoes!

mcg/g wet weight

Ishida et al., J Agric Food Chem 52:274, 2004


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Gac Fruit Beta-CaroteneContent

10 x more

than carrots!

mcg/g wet weight

Ishida et al., J Agric Food Chem 52:274, 2004


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Zeaxanthin in Chinese Lycium Fruit

40 x more than

yellow corn!

mcg/g wet weight


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Vitamin C in Cili Fruit

60 x more

than oranges!

mg/100g wet weight


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Vitamin C

Vitamin E

Antioxidant protection


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Carotenoid protection

Betacarotene


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Betacarotene

Lutein

Carotenoid protection


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UVA

UVB

Visible

Carotenoid protection

Betacarotene

Lutein

Lycopene


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Betacarotene

Vitamin C

Lutein

Lycopene

Vitamin E

Antioxidant protection



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Carotenoids

  • First line of defense antioxidants*

  • Protect cell membranes*

  • Protect DNA*

  • Enhance communication in cell membranes*

  • Found in a diet rich in fruits and vegetables

  • Indicator of overall antioxidant health*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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Carotenoids Predict Antioxidant Status

  • Recent paper published in the Journal of Nutrition

    • Carotenoids (blood) are indicator of total antioxidant status

    • Carotenoids interact with the antioxidant network

    • Vitamin E (blood) is not a good indicator of antioxidant status


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Carotenoid molecules shift blue laser light color to green:

from 473 nm to 510 nm

Raman Spectroscopy

Intense monochromatic light (one color only) interacts with molecules that have vibrational energy (e.g., carotenoids) and gets scattered at a higher wavelength (color).

Sir C. V. Raman, Nobel Prize in Physics, 1930


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Pharmanex BioPhotonic Scanner

  • Measures skin carotenoids –an indication of your personal antioxidant protection

  • Easy & non-invasive

  • Scientifically and clinically validated

  • Gold standard

Measure antioxidant effect of g3 in your own body!


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1.10

tomato juice

1.00

0.90

Relative risk

tomato fruits

0.80

pizza

0.70

tomato sauce

0.60

0

1

2

3

Servings

Bioavailability

Effect of tomato food products on prostate health risk

from Giovanucci et al. J. of Natl. Canc. Inst. 87, 1767 (1995)


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50,000

1

40,000

2

3

4

Antioxidant Network Score

5

30,000

6

7

8

9

10

20,000

11

10,000

Week 0

Week 8

g3Increased Antioxidant Network Scores ~9,500 in 8 Weeks


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Noni & Xango vs. g3

10,000

Tahitian Noni

XanGo

8,000

6,000

Antioxidant Score

4,000

2,000

0

Week 0

Week 2

Week 4

Week 6

Week 8


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Other Ingredients

Chinese Lycium

(Wolfberry; Lycium chinense)

2000 years TCM history in China

  • Longevity, wellness, vision

  • Cellular rejuvenation:* protects DNA*

    • antioxidant (SOD, GPX)

Cili Fruit

(Rosa roxburghii)

  • Cardiovascular, antioxidant benefits:*

    • ↓ oxLDL, increases SOD*

  • Addresses symptoms of Aging*

*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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Is Catalytically Active

g3 activates SOD and Catalase*

  • the body's catalytic antioxidant system

  • antioxidant protection inside the cell, where it is needed the most

    SOD: Superoxide Dismutase

  • most important antioxidant enzyme

  • requires copper, zinc & manganese (LifePak)

*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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Betacarotene

Lutein

Vitamin C

Lycopene

Vitamin E

Vulnerable to Oxidation


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SOD

Catalase

Vitamin E

SOD

CAT

Internal Antioxidants


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The Measurable Difference

You have the 3 most powerful tools of the entire nutritional supplement industry worldwide:

  • lifepak nano: The best multi-nutrient supplement.

  • : The best functional fruit juice.

  • BioPhotonic SCANNER: The best consumer test for antioxidant nutrition.


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Key Business Takeaways

  • G3™ supports your body’s antioxidant network*

  • Lipocarotenes™ naturally increase absorption of antioxidants*

  • SCS Certified ~ 9,500 increase in 8 weeks

    • 6 times more powerful than Noni or Xango™*

  • Proprietary and patent pending

*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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More Information

Presentations

www.pharmanexusa.com

Leadership Conference link

My Office  Marketing Tools

Product Resources

www.pharmanexusa.com

www.pharmanexscanner.com

Product Support

E-Mail: [email protected]

Phone: 1-800-487-1000


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