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National Naval Medical Center Directorate for Professional Education Clinical Investigations Department. Introduction to Research at NNMC Marina Borovok, PhD Head of Research Education, Clinical Investigations Department, NNMC

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National Naval Medical CenterDirectorate for Professional EducationClinical Investigations Department

Introduction to Research at NNMC

Marina Borovok, PhD

Head of Research Education,

Clinical Investigations Department,

NNMC

“The National Naval Medical Center is an approved provider of continuing nursing education by the Navy Medicine Manpower, Personnel, Training and Education Command, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation.”

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Disclosure Statement :

This CE/CME activitydoes not have commercial support,and has no conflicts of interest.

Research Course

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2

learning objectives
Learning Objectives
  • Describe clinical research and the research process steps
  • Discus research at NNMC and it’s unique opportunities.

3. Know about research support available at NNMC.

  • Recognize IT tools that support research collaboration and communication from anywhere at any time.

Research Course

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3

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"There is always a better way to do it.

Find it !!!"

— Thomas A. Edison

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how we can find a better way to do it
How we can find “a better way to do it”?

Only through the best available scientific knowledge,

and research-based decision making.

Research Course

lo 1 describe clinical research and the research process steps
LO 1: Describe clinical research and the research process steps

Before you start your research at NNMC, you need to do the following THREE steps:

Step 1: Obtaining a DKO/AKO account

Step 2: Registering with IRBNet, e-portal for publications and protocolsubmission.

Step 3: Completion of CITI training

Research Course

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Research Cue Card

Research Course

step 1 obtaining a dko ako account
Step 1: Obtaining a DKO/AKO account

Go to the DMRN page on DKO/AKO website at https://www.us.army.mil/suite/page/596540

Cue Card Reference:

Research Course

step 1 obtaining a dko ako account cont
Step 1: Obtaining a DKO/AKO account(cont.)

Login using your AKO/DKO username and password

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step 1 obtaining a dko ako account cont1
Step 1: Obtaining a DKO/AKO account(cont.)

You are at the DMRN site at https://www.us.army.mil/suite/page/596540

Click on the IRBNet Entry button

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step 1 obtaining a dko ako account cont2
Step 1: Obtaining a DKO/AKO account(cont.)

Instructions are at the RCRS website

https://nnmcintra/SiteDirectory/RCRS/IRBNet/Forms/AllItems.aspx.

Questions?

Please contact Mr. Luis Calvo at [email protected],

301 295-2269.

Research Course

step 2 registering with irbnet e portal for publications and protocol submission
Step 2: Registering with IRBNet, e-portal for publications and protocol submission.

Cue Card Reference:

Instructions are at the RCRS website

https://nnmcintra/SiteDirectory/RCRS/IRBNet/Forms/AllItems.aspx.

Research Course

step 2 registering with irbnet e portal for publications and protocol submission cont
Step 2: Registering with IRBNet, e-portal for publications and protocol submission (cont.)

Questions?

Please contact Mr. Luis Calvo

at [email protected],

301 295-2269.

Research Course

step 3 completion of citi training
Step 3: Completion of CITI training

Cue Card Reference:

Principal Investigators, Associate Investigators, Research Staff, as well as anyone coming into contact with Human Subjects or involved with the consent process or study design are required to complete this course.

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step 3 completion of citi training1
Step 3: Completion of CITI training

The course is available at https://www.citiprogram.org

First Time Users need to register at

https://www.citiprogram.org/enroll/courseregistration1.asp?language=english.

Questions?

Please contact Mrs. Toby Perkins

at [email protected], 301 319-8994.

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next steps 4 5
Next steps: 4-5

The entire research writing process can be divided into easily manageable and clear steps:

STEP 4: Develop a Research Question

Select a topic

Find Sources to support your ideas

STEP 5: Research Protocol Preparation:

Literature Review

Start Writing

Statistical Analysis

Complete Detailed Study Protocol

STEP 6: Submit your proposal via

Proposal Approval

Funding (if needed)

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STEP 4:Good research question: could the "FINER" criteria be applied to it?F- Feasible.  Is the question answerable?  Do you have access to all the materials you will need to do the study?  Do you have access to enough subjects?  Will you have enough time and money?  Do you have the expertise to do this study or can you collaborate with someone who does?I- Interesting.  The question has to be interesting to the investigator, but should also be interesting to others.N- Novel.  Has this study been done before?  Does it add to the current body of medical knowledge?E- Ethical.  Risk/benefit ratio? Can the study be done with a minimal risk?  Will an IRB approve the study?R- Relevant.  Will it further medical science?  Will the results change clinical practice, health policy or point towards further avenues of research?If your question fails on any one of these 5 criteria, it is probably not worth putting much effort into.Additional reading:http://familymed.uthscsa.edu/facultydevelopment/elearning/ResearchQuestions.swf

step 4 research topic selection
Step 4: Research topic selection

Cue Card Reference:

In order to do that you need to consult with your Department Chair/Supervisor/Mentor.

Need help to choose your Mentor?

Please contact Dr. Marina Borovok

at [email protected], 301 295-2876.

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step 4 research topic selection cont in case if you need help
Step 4: Research topic selection (cont.)In case if you need HELP

Choose your mentor, and ask him/her to help.

Web resource :

http://www.bethesda.med.navy.mil/professional/research/responsible%5Fconduct

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step 5 research protocol preparation
Step 5: Research Protocol Preparation

Literature Search help:

Mr. Fredric Simms, MLS

Medical Researcher,

Phone: (301) 295-0080

E-mail address: [email protected]

Bldg. 1, 1st floor, rm 1633

Statistical Data Analysis help:

Dr. Francois O. Tuamokumo

Mathematical Statistician

Phone: (301) 319 8788

Email: [email protected]

Bldg. 1, 4th floor, rm 4342

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step 5 research protocol preparation cont literature review
Step 5: Research Protocol Preparation (cont.) Literature Review

Finding Sources to support your ideas

Sources come in many forms, such as magazine and journal articles, books, newspapers, videos, films, computer discussion groups, surveys, or interviews.

The trick is to find and then match appropriate, valid sources to your own ideas.

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step 5 research protocol preparation cont comprehensive lit db search
Step 5: Research Protocol Preparation (cont.) Comprehensive Lit DB search

Need help with multiple literature DB?

Please contact Mr. Fredric Simms, MLS

Medical Researcher,

E-mail address: [email protected] Call: 301-295-0080

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step 5 research protocol preparation cont start writing complete detailed study protocol
Step 5: Research Protocol Preparation (cont.) Start Writing, Complete Detailed Study Protocol

Human Use Protocol is available on the web at:

http://www.bethesda.med.navy.mil/professional/research/responsible_conduct/Forms/index.aspx

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step 6 protocol submission via
Step 6: Protocol submission via

Cue Card Reference:

Submission instructions are available on the IRBNet portal, under Forms and Templates.

Questions?

Please contact RCRS at

[email protected],

301 295-2275.

Research Course

next steps are proposal approval srp irb approval funding if needed
Next steps are: Proposal Approval (SRP,IRB approval), Funding (if needed)

These steps will be successful if you worked on the Research Protocol with help of the NNMC specialists (Step 5) 

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research funding
Research Funding

Information on Research Funding is provided

By Dr. Kaminsky (Day 2, Module 9).

Another resource: The Geneva Foundation (slides 65-69)

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important to remember
IMPORTANT TO REMEMBER !!!

Cue Card Reference: 

You may not begin your research until

you have received

an IRB Approval andApproval Letter

from the Commander, NNMC.

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the walter reed army medical center wramc
The Walter Reed Army Medical Center (WRAMC)

The Walter Reed Army Medical Center (WRAMC) processes are very similar to NNMC, since both centers follow most of the same regulations.

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the national capital region military medical centers pocs
The National Capital Region Military Medical Centers POCs:

National Naval Medical Center (NNMC) ,

Responsible Conduct of Research Service Sheila Gaines 301-295-6512

Walter Reed Army Medical Center (WRAMC),

Department of Clinical Investigation Verna Parchment 202-782-7828

Malcolm Grow Medical Center (MGMC),

IRB Office Cheryl James 240-857-8216

The Uniformed Services University (USU),

Research Office Maggie Pickerel 301-295-0819

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questions
Questions?

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lo 2 discus research at nnmc and it s unique opportunities
LO 2: Discus research at NNMC and it’s unique opportunities

Naval Medical Research Today

  • 51,000 Navy medical personnel
  • Patients: 786,000 active duty Navy and Marine Corps personnel,

886,000 dependents, Navy and Marine Corps retirees, and their

TOTAL: 1,126,600 of a total beneficiary population of almost 3,000,000 people.

  • Navy Medicine operates 33 hospitals, 213 medical clinics, 168 dental clinics and five drug screening laboratories.
  • In addition, the community includes a research and development command, which includes medical and dental health research institutes, units and laboratories. The community has its own health sciences education and training command which operates four schools.

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research at nnmc
Research at NNMC

NNMC’s goal remains to promote excellence in health care and militarily relevant research and human subject protection.

Our command supports effective and sustainable research, and encourages you to become part of that!

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research at nnmc1
Research at NNMC
  • Current research efforts at NNMC are ongoing:

head injury/TBI, stroke,

colon, breast cancer, leukemia and lymphoma,

investigational chemotherapy,

virtual colonoscopy,

diabetes management,

infectious disease,

dental imaging.

2009 NNMC Publications Data

245 Publications

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recent nnmc publications
Recent NNMC Publications

Inflammatory Biomarkers in Combat Wound Healing

Hawksworth, Jason S. MD; Stojadinovic,

Alexander MD; Gage, Frederick A.; Tadaki,

Doug K. PhD; Perdue, Philip W. MD;

Forsberg, Jonathan MD; Davis, Thomas A. PhD;

Dunne, James R. MD; Denobile, John W. MD;

Brown, Trevor S. PhD; Elster, Eric A. MD

Annals of Surgery • Volume 250, Number 3, September 2009

There was an article in USA Today about this study: “Navy research could speed troops’ recovery” (see next slide)

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recent nnmc publications1
Recent NNMC Publications

http://www.videomd.com/AntibioticsandProbioticsinIBS-fv-2444.aspx

Dr. Brooks Cash,

Chief of Gastroenterology at NNMC

Videopresentation by Dr. Cash

Antibiotics and Probiotics in IBS from Brooks Cash, MD

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recent nnmc publications2
Recent NNMC Publications

Prosthesis Retention, Serial Debridement, and Antibiotic Bead Use for the Treatment of Infection Following Total Joint Arthroplasty

By LT Scott M. Tintle, MD, MC, USN; LCDR Jonathan A. Forsberg, MD, MC, USN; MAJ Benjamin K. Potter, MD, MC, USA; Richard B. Islinger, MD; LTC Romney C. Andersen, MD, MC, USAORTHOPEDICS 2009; 32:87

Dr. Forsberg

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open protocols at nnmc
Open Protocols at NNMC

List is available on the Intranet at:

https://nnmcintra/SiteDirectory/RCRS/Lists/Open%20Protocols/AllItems.aspx?View=%7b40123BB7%2dBE3A%2d4899%2d9423%2dB28C17B522E1%7d

Go to the Responsible Conduct of Research Service (RCRS) Intranet site at https://nnmcintra/SiteDirectory/RCRS/default.aspx

and click on Open Protocols

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questions1
Questions?

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lo 3 know about research support available at nnmc
LO 3:Know about research support available at NNMC.

NNMC Research Resources

Responsible Conduct of Research Service (RCRS) – HUMAN SUBJECT PROTECTION,

Stitt library (new name: Darnall Biomedical Learning Resource Center)

Research Protocol/Publication Help,

Education/Mentoring Resources,

ICEBERG,

IT tools.

External support:

The Geneva Foundation

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rcrs information
RCRS information

Bldg. 1, 4th floor, room 4394

RCRS Intranet https://nnmcintra/SiteDirectory/RCRS/default.aspx

RCRS Internet http://www.bethesda.med.navy.mil/professional/research/Responsible_Conduct/index.aspx

Questions: 301 295-2275

[email protected]

Head of the Clinical Investigation Department:

CAPT Jeffrey Lenert, MD

[email protected]

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stitt library
STITT LIBRARY

Recently renamed: Darnall Biomedical Learning Resource Center

Bldg. 8, 3 rd floor, room 3458

Stitt Intranet

https://nnmcintra/SiteDirectory/STITT/default.aspx

Stitt Internet

http://www.bethesda.med.navy.mil/professional/stitt_library

Questions: 301 295-1184

[email protected]

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research protocol publication help
Research Protocol/Publication Help

Literature Search:

Comprehensive DB specialist: Mr. Fredric Simms, MLS

[email protected] 301 295-0080

Statistical Data Analysis:

Mathematical Statistician: Francois O. Tuamokumo, PhD

[email protected] 319-8788

All specialists provide hands-on workshops.

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education mentoring resources
Education/Mentoring Resources

Head of Research Education: Marina Borovok, PhD

[email protected] 295-2876

Cue Card Reference:

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educational resources
Educational Resources

Research Course: 9 CME/CE, 2 days (0630-1100); 2010: 7/15-16, 9/23-24, 11/1-2. Course PP slide show is available at: https://nnmcintra/SiteDirectory/RCRS/default.aspx

Hands-on Research Preparation Course: April-December, 2010, Th., noon-1400. Information is available on the web at:

http://nnmcresearch.wikispaces.com/Hands-on+Research+Preparation+Course

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educational resources cont
Educational resources (cont.)

PubMed Search Course

Developed and presented by the National Library of Medicine

DATES: Friday, December 10, 2010 at 0900-1115

TIME: 0900 - 1115

LOCATION: NNMC, Bldg 5, room 437

Course Schedule 

Part I (09:00 – 10:00) Using PubMed (Lecture)

Part II (10:15 – 11:15) Practice with PubMed (hands-on practice)

Course Instructors: Annette Nahin, Margaret McGhee, Elizabeth Frost

COURSE GOAL

  • To provide guidelines for PubMed search, and teach researchers how to perform searches on their own.

REGISTRATION:

PLEASE CONTACT Ms. Ann Holman: 301-319-8411, or via e-mail at

[email protected]

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pubmed links
PubMed LINKS

The PubMed links are posted on the Intranet:

RCRS and Stitt Library websites

RCRS website

https://nnmcintra/SiteDirectory/RCRS/default.aspx

Stitt Library Website

https://nnmcintra/SiteDirectory/STITT/default.aspx

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pubmed links1
PubMed LINKS
  • at http://www.nlm.nih.gov/bsd/disted/pubmed.html
  • One-day PubMed training course http://nnlm.gov/ntcc/classes/regions.html#
  • 1-Hour Webcast " PubMed Search" https://webmeeting.nih.gov/p15252398/
  • How to create MY NCBI Account

https://nnmcintra/SiteDirectory/RCRS/default.aspx

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hands on educational workshops
Hands-on Educational WORKSHOPS

Workshops are offered all year long at NNMC on a per-request basis.

Topics:

  • Literature Search by Mr. Fredric Simms
  • Statistical Analysis by Dr. Tuamokumo

Please contact our specialists to schedule a workshop

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nnmc usuhs mentorship initiative
NNMC-USUHS mentorship initiative
  • USUHSIf you are looking for a mentor in the specific areas of research, clinicalwork, education, professional development, please contact mentorshiprepresentatives at USUHS, and they will help you to find a mentor from theUSUHS mentorship network:
  • Andrew Waters, Ph.D ([email protected]) Chair of Research CommitteeDr. Jennifer Rusiecki ([email protected]) or Dr. Barbara Knollman ([email protected]) Co-chairs of Faculty Mentoring Committee
  • NNMCIf you are looking for a mentor in the specific areas of military research,please contact research mentorship representative at NNMC:
  • Marina Borovok, PhD ([email protected])Head of Research Education.

On the web:

http://www.bethesda.med.navy.mil/professional/research/responsible%5Fconduct/

http://nnmcresearch.wikispaces.com/NNMC-USUHS+Mentorship+Project

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interdepartmental collaborative bethesda research group
Interdepartmental Collaborative BethesdaResearch Group

http://nnmcresearch.wikispaces.com/

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iceberg mission
ICEBERG Mission

Help National Naval Medical Center

to become

a premier research organization

in the Department of Defense.

ICEBERG’s Mentorship Initiative:

http://nnmcresearch.wikispaces.com/MENTORSHIP

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research funding external resource the geneva foundation
Research Funding: External ResourceThe Geneva Foundation

Established in 1993 at the request of Madigan Army Medical Center

in Tacoma, WA

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the geneva foundation
The Geneva Foundation

Research Experience

Geneva supports research in numerous therapeutic areas to include, but not limited to, the following:

  • Allergy, Asthma, and Clinical Immunology
  • Cardiology
  • Endocrinology, Diabetes, & Metabolism
  • Gastroenterology
  • General Surgery
  • Hematology/Oncology
  • Infectious Diseases
  • Internal Medicine
  • Mental Health Services
  • Neurology
  • Orthopedics
  • Pulmonary/Critical Care
  • Urology

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the geneva foundation1
The Geneva Foundation

The Grants and Contracts Department (GCD)

works with a variety of investigators on many

different types of awards:

Current Portfolio

  • Federal and non-industry sponsored grants
  • Federal and non-federal contracts in support of personnel
  • Federal and non-federal contracts in support of research programs
  • Cooperative Agreements

Research Course

the geneva foundation www thegenevafoundation org
The Geneva Foundationwww.thegenevafoundation.org

If you are interested in using Geneva\'s services for the preparation of your proposal, please contact the following people:

Mr. Jim Hulbert, Grants and Contracts Manager

(253) 682-3820

[email protected]

Ms. Anne Reedy, Chief of Research and [email protected] Elise Huszar, [email protected]

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the geneva foundation2
The Geneva Foundation

Why Partner with Geneva

  • Superior customer service tailored to each investigator and each project
  • Established partnerships with MTFs, federal laboratories, and sponsors
  • Proposal developmentsupport
  • Comprehensive post-award management services
  • Trained research team personnel to include SOPs for study conduct and ongoing performance checks
  • Accurate, timely financial reporting

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questions2
Questions?

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resources it tools
Resources: IT tools

Turnitin

Turnitin is a Plagiarism Prevention Software.

Website: http://www.turnitin.com/static/index.html

  • Plagiarism Prevention:Instantly identifies papers containing unoriginal material.
  • Peer Review:Participants can review and respond to their colleagues\' work online.

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resources it tools1
Resources: IT tools

Turnitin

To schedule a training session or to create an account please contact

Ms. Ann Holman:

301-319-8411, or via e-mail at

[email protected]

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resources it tools2
Resources: IT tools

IRBNet

www.irbnet.org

  • IRBNet is the industry leading software, a robust set of electronic tools supporting the management, submission, review and oversight of our research protocols.
  • IRBNet is secure, web-based, and easy to use.

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LO 4: Recognize IT tools that support research collaboration and communication from anywhere at any time.

COLLABORATIVE E-PLATFORMS

Electronic platforms that support synchronous and asynchronous communication through a variety of software, services, devices and channels are called collaborative e-platforms.

Typical web-based collaborative e-platforms support synchronous and asynchronous communication, and therefore enable more effective team collaboration

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synchronous and asynchronous communication
Synchronous and Asynchronous communication

Synchronous communication: real time multi-user communication, requires that all parties involved in the communication be present at the same time.

Examples: Data conferencing, Instant messaging, LAN messenger, Videoconferencing, Voice chat, VoIP, Web chat, Web conferencing

Asynchronous communication: does not require that all parties involved in the communication be present at the same time.

Examples: Blog, E-mail, Electronic mailing list, Message Board (Internet forum), Wiki

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collaborative e platforms
Collaborative E-platforms
  • Best collaborative platform Army Knowledge Online (AKO/DKO)

Synchronous: Defense Connect Online (DCO)

  • Wikis - Asynchronous
  • Google Docs - Asynchronous

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virtual meeting room dco
Virtual meeting room DCO

https://www.dco.dod.mil

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dco defense connect online
DCO– Defense Connect Online
  • DCO– Defense Connect Online - provides DoD users worldwide with a second option for enterprise collaboration services.
  • The DCO meeting room capabilities are: the DCO Portal, webconferencing, instant messaging, screen and file sharing, whiteboard, video and audio capabilities, hosting large meetings, and more.

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virtual meeting room dco1
Virtual meeting room DCO

2010Live Training Sessions:

schedule is available at https://www.dco.dod.mil/public/dsp/liveTraining.cfm

To participate in live training:

Go to

https://connect.dco.dod.mil/dcoliveremotetraining

Enter as a [email protected]

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wikis http www wikispaces com
Wikis http://www.wikispaces.com/

A wiki is a website that can be edited by anyone who is granted permission.

It is simple and powerful knowledge sharing and collaboration online tool that solves problems of Document management for a Team Project Management in an enterprise.

Other advantages of wiki:

cheap or free, simple enough for non-technical employees to use.

Detailed instructions on how to create a wiki page are available at http://www.umich.edu/~umctdocs/Wiki.html

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wikis
Wikis

Wiki Examples:

Wikilawhttp://www.wiki-law.org/mwiki/?title=Main_Page

Wikipedia: http://en.wikipedia.org/wiki/Main_Page

Wiki Applications

TikiWiki http://info.tikiwiki.org/tiki-index.php

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wikis1
Wikis

Wiki at NNMC

  • ICEBERG (Interdepartmental Collaborative Bethesda Research Group) http://nnmcresearch.wikispaces.com/

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google docs
Google Docs

https://www.docs.google.com

GoogleDocs is a free web-based collaborative software.  It has applications of word processors, spreadsheet and presentations that are similar to Word, Excel and PowerPoint.

Several useful functions are: autosave, revision history and rename of the files.

It allows users to create

and edit documents online

while collaborating in

real-time with other users.

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slide85
References:

Hulley, S. et al.(2007), Designing Clinical Research, 2nd ed. Lippincott Williams & Wilkins

On Being a Scientist: A Guide to Responsible Conduct in Research: Third Edition. (2009). Committee on Science, Engineering, and Public Policy,

National Academy of Sciences, National Academy of Engineering, and Institute of Medicine. http://www.nap.edu/catalog/12192.html

  • Goodnoe, E. (2005). How To Use Wikis For Business. The InformationWeek Business Technology Network. Retrieved March 11, 2010, from http://www.informationweek.com/news/management/showArticle.jhtml?articleID=167600331
  • Pfeifer, S. (March 11, 2008). Wikis and Blogs. Presented at Administrative and Instructional Uses of Technology, ED.851.609 (91) lecture at Johns Hopkins University.
  • Riedel, C. (2008).Turnitin Integrates Plagiarism Tool into New Online Writing Service. Retrieved March 10, 2010, from http://campustechnology.com/articles/2008/09/turnitin-integrates-plagiarism-tool-into-new-online-writing-service.aspx
  • Auga, N. (2006). Developing wikis to foster web-based learning communities: an iterative approach, International Journal of Web Based Communities (IJWBC), Vol.2, No.3. Retrieved March 12, 2010, from http://www.inderscience.com/offer.php?id=11761

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questions3
Questions?

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thank you
Thank You!

My Contact Information:

Marina Borovok, PhD

Head of Research Education

Clinical Investigation Department

Professional Education Directorate

National Naval Medical Center

8901 Wisconsin Avenue,

Bldg. 1, Rm. 4372,

Bethesda, MD 20889

Phone: 301-295-2876

Fax: 301-295-1490

E-mail: [email protected]

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