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Insulin Bioreactor Design. CHEE 450 Thursday, March 29. Reactor Considerations. Production of insulin precursor 5000 kg insulin per year Assumes 20 % loss due to purification k L a within 10% of 2088 hr -1 Prevents oxygen limited reaction Prevents anaerobic metabolism

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insulin bioreactor design

Insulin Bioreactor Design

CHEE 450

Thursday, March 29

reactor considerations
Reactor Considerations
  • Production of insulin precursor
  • 5000 kg insulin per year
    • Assumes 20 % loss due to purification
  • kLa within 10% of 2088 hr -1
    • Prevents oxygen limited reaction
    • Prevents anaerobic metabolism
  • Glucose concentration < 0.5 g/L
    • Prevents formation of ethanol
  • CSTR configuration
  • Jacket heat exchanger
  • Price
how unit operates
How Unit Operates
  • Substrate feed
    • Glucose, ammonia, mineral salts
  • Cellular metabolism of substrate
  • Extracellular production of insulin
  • Air sparging for oxygen delivery
  • Impellers for mixing of nutrients and oxygen
bioreactor specifications

Di

1.3 m

HL**= 6.06m

HL*= 5.5 m

Dt

1.50 m

Bioreactor Specifications

Total volume = 11.8 m3

companies that produce insulin
Companies That Produce Insulin
  • Sanofi Pasteur
  • Novonordisk
  • Eli Lilly
  • Average cost = $40/100 I.U. or ~$800/kg
  • Final production cost ~$12/kg precursor
    • Includes capital and operating costs (minus medium)
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