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Insulin Bioreactor Design. CHEE 450 Thursday, March 29. Reactor Considerations. Production of insulin precursor 5000 kg insulin per year Assumes 20 % loss due to purification k L a within 10% of 2088 hr -1 Prevents oxygen limited reaction Prevents anaerobic metabolism

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Insulin Bioreactor Design

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Insulin bioreactor design l.jpg

Insulin Bioreactor Design

CHEE 450

Thursday, March 29


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Reactor Considerations

  • Production of insulin precursor

  • 5000 kg insulin per year

    • Assumes 20 % loss due to purification

  • kLa within 10% of 2088 hr -1

    • Prevents oxygen limited reaction

    • Prevents anaerobic metabolism

  • Glucose concentration < 0.5 g/L

    • Prevents formation of ethanol

  • CSTR configuration

  • Jacket heat exchanger

  • Price


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How Unit Operates

  • Substrate feed

    • Glucose, ammonia, mineral salts

  • Cellular metabolism of substrate

  • Extracellular production of insulin

  • Air sparging for oxygen delivery

  • Impellers for mixing of nutrients and oxygen


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Di

1.3 m

HL**= 6.06m

HL*= 5.5 m

Dt

1.50 m

Bioreactor Specifications

Total volume = 11.8 m3


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Final Design Specifications


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Final Design continued….


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Companies That Produce Insulin

  • Sanofi Pasteur

  • Novonordisk

  • Eli Lilly

  • Average cost = $40/100 I.U. or ~$800/kg

  • Final production cost ~$12/kg precursor

    • Includes capital and operating costs (minus medium)


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Novonordisk Bioreactor


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Questions?


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