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The Effects of β-Adrenergic Antagonists on Radiotherapy for Locally Advanced Lung Cancers

The Effects of β-Adrenergic Antagonists on Radiotherapy for Locally Advanced Lung Cancers. Poster #  1139. Simon K. Cheng 1 , Kevin Stephenson 2 , Lynn Shi 2 , Kunal Chaudhary 1 , Anshu Jain 1 , David P. Horowitz 1 , Sherry X. Yan 2 , Tony Wang 1 , Clifford Chao 1 , Tom K. Hei 1

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The Effects of β-Adrenergic Antagonists on Radiotherapy for Locally Advanced Lung Cancers

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  1. The Effects of β-Adrenergic Antagonists on Radiotherapy for Locally Advanced Lung Cancers Poster #  1139 Simon K. Cheng1, Kevin Stephenson2, Lynn Shi2, Kunal Chaudhary1, Anshu Jain1, David P. Horowitz1, Sherry X. Yan2, Tony Wang1, Clifford Chao1, Tom K. Hei1 1New York Presbyterian Hospital / Columbia University Medical Center, 2Columbia University, New York, NY

  2. Disclosures: None

  3. β-Adrenergic Pathway and Cancer – cancer patients are exposed to catecholamines under chronic stress conditions – promotes cellular proliferation, tumor invasion, angiogenesis, and resistance to chemotherapy-induced apoptosis – beta-blockers commonly used to treat hypertension and cardiac disease

  4. Propanolol is a Radiosensitizer PC9 lung cancer cells

  5. Columbia Local Advanced NSCLC Cohorttreated with tri-modality therapy~60 Gy RT + cisplatin-based chemo  surgery

  6. Local Primary Tumor Response NS NS

  7. Distant Metastases Rate p=0.007 *

  8. Overall Survival

  9. Conclusions – β-adrenergic pathway may regulate multiple processes that contribute to tumor progression and treatment response – propranolol radiosensitizes lung cancer cells to radiation in vitro – beta-blocker use was associated with a decreased distant metastases rate and improved overall survival at 1 year In LA-NSCLC pts treated with tri-modality therapy

  10. Conclusions – Need additional studies evaluating the benefits of beta-blocker use on radiation treatment response and lung cancer recurrence – Commonly targeted medical pathways may have significant pleomorphic effects on the efficacy of cancer therapies – e.g. NRG LU001 Randomized Phase II Trial of Concurrent Chemoradiotherapy +/- Metformin HCL in Locally Advanced NSCLC

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