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Seminar 07. Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning. nuclei TO-PRO-3 |anti-GFP antibody. DOX (+) Home cage. DOX (+) 24 hrs FC. DOX (-) Home cage. DOX (-) 24 hrs FC. Novel context alone can induce c-fos promoter in CA1 field.

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Seminar 07

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Seminar 07

Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning


nuclei TO-PRO-3 |anti-GFP antibody

DOX (+)

Home cage

DOX (+)

24 hrs FC

DOX (-)

Home cage

DOX (-)

24 hrs FC


Novel context alone can inducec-fos promoter in CA1 field


DiI crystals to label dendrites


New GluR1 found onsome dendritic spine heads


Anatomical classification of spines


FC transiently increases % mushroom spines with new GluR1


No difference between apical and basal CA1 dendrites


Extinction protocol


Extinction of contextual FC


Extinction learning actually prolongs requirement for new GluR1


No changes in the density of spines or the distribution of spine types


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