Seminar 07
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Seminar 07. Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning. nuclei TO-PRO-3 |anti-GFP antibody. DOX (+) Home cage. DOX (+) 24 hrs FC. DOX (-) Home cage. DOX (-) 24 hrs FC. Novel context alone can induce c-fos promoter in CA1 field.

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Seminar 07

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Seminar 07

Seminar 07

Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning


Nuclei to pro 3 anti gfp antibody

nuclei TO-PRO-3 |anti-GFP antibody

DOX (+)

Home cage

DOX (+)

24 hrs FC

DOX (-)

Home cage

DOX (-)

24 hrs FC


Novel context alone can induce c fos promoter in ca1 field

Novel context alone can inducec-fos promoter in CA1 field


Dii crystals to label dendrites

DiI crystals to label dendrites


New glur1 found on some dendritic spine heads

New GluR1 found onsome dendritic spine heads


Anatomical classification of spines

Anatomical classification of spines


Fc transiently increases mushroom spines with new glur1

FC transiently increases % mushroom spines with new GluR1


No difference between apical and basal ca1 dendrites

No difference between apical and basal CA1 dendrites


Extinction protocol

Extinction protocol


Extinction of contextual fc

Extinction of contextual FC


Extinction learning actually prolongs requirement for new glur1

Extinction learning actually prolongs requirement for new GluR1


No changes in the density of spines or the distribution of spine types

No changes in the density of spines or the distribution of spine types


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