VACCINES AND RELATED BIOLOGICAL PRODUCTS ADVISORY COMMITTEE The Public Health Need for Pandemic Influenza Vaccines. Jesse L. Goodman, M.D., M.P.H. Chief Scientist Food and Drug Administration November 14, 2012. Public Health Impacts of 2009 Pandemic Influenza A (H1N1) and of immunization.
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VACCINES AND RELATED BIOLOGICAL PRODUCTS ADVISORY COMMITTEEThe Public Health Need for Pandemic Influenza Vaccines
Jesse L. Goodman, M.D., M.P.H.
Food and Drug Administration
November 14, 2012
The risk of pandemic influenza remains serious
1918 1956 1968 2009 ?
Spanish Asian Hong Kong Swine Flu H5N1
Flu Flu Flu (H1N1)
25,000,000 70,000 34,000 +450 +359 deaths
deaths deaths deaths deaths Since 2003
Unlike 2009 H1N1, H5N1 currently has a low human-to-human transmission rate but a very high mortality rate; more than half of recent human cases of documented infection H5N1 avian influenza were fatal (WHO, 2006). Also unlike H1N1, H5N1 is poorly immunogenic and the population does not have background immunity
Source: WHO/GIP, data in HQ as of 10 August 2012