Light Propagation in the Mice’s Organs Optical Ray-tracing Project. Haiyan Xie, Atomic Physics Division Lund University. Outline. Introduction Aim of this project Photodynamic therapy (PDT) Variations of optical parameters, i.e., μ a , μ s , and g, in PDT Experiments and Simulations
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Light Propagation in the Mice’s OrgansOptical Ray-tracing Project
Atomic Physics Division
To simulate the light distribution in the animal organs after the photodynamic therapy (PDT).
2 mm fiber seperation
The path length of the collected
photons is relatively insensitive to
the tissue scattering variations.
Tumor / Organ
Left) Ex vivo absorption spectroscopy measurements, OPS-1000
Biospectrometer TM (Optimum Technologies, Inc), and
Right) Sample tissues.
System geometry in the FRED simulation.
The concentrations of different chromophores have been changed.
’s concentration changes
’s the corresponding extinction coefficients, dependent on the
Extinction coefficients of mTHPC, Hb and HbO.
Absorption of water.
Absorption coefficients of the mouse tissues
Simulation Results (1)
Simulation Results (2)
A disadvantage of the FRED software when dealing with a scattering process?