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Hematology Pimp Session

Hematology Pimp Session. 1. What is the sequence of the intrinsic pathway of coagulation?.

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Hematology Pimp Session

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  1. HematologyPimp Session

  2. 1. What is the sequence of the intrinsic pathway of coagulation?

  3. Prekallikrein+ HMW kininogen + factor XII + exposed collagen → activates Factor XI → activates Factor IX +Factor VIII → activates Factor X + Factor V → converts prothrombin (Factor II) to thrombin → thrombin converts fibrinogen to fibrin

  4. 2. What is the sequence of the extrinsic pathway of coagulation?

  5. Factor VII + tissue factor → activates Factor X +Factor V → converts prothrombin to thrombin → thrombin converts fibrinogen to fibrin

  6. 3. Which factors are known as the labile factors (i.e. activity lost in stored blood)?

  7. Factors V and VIII

  8. 4. Which factor has the shortest half-life?

  9. Factor VII

  10. 5. What are the Vitamin K dependent factors?

  11. Factors II, VII, IX, and X and proteins C and S

  12. 6. Which factor is the convergence point for both the extrinsic and intrinsic pathways of coagulation?

  13. Factor X

  14. 7. PT measures the function of which factors?

  15. Factors II, V, VII, and X and fibrinogen

  16. 8. PTT measures the function of which factors?

  17. Factors II, V, VIII, IX, X, XI, and XII and fibrinogen

  18. 9. What 2 electrolytes are required for the formation of a platelet plug?

  19. Calcium and Magnesium

  20. 10. What is the sequence of physiologic reactions that mediate hemostasis following vascular injury?

  21. 1. Vasoconstriction 2. Platelet activation/adherence/aggregation 3. Thrombin generation

  22. 11. Uremia leads to a downregulation of?

  23. GpIb, GpIIb/IIIA, and vWF

  24. 12. What is the treatment of choice for uremic coagulopathy?

  25. Dialysis

  26. 13. Which drug can be given to help correct platelet dysfunction from uremia, bypass, or ASA?

  27. Desmopressin(DDAVP)

  28. 14. DDAVP and conjugated estrogens stimulate the release of?

  29. Factor VII and vWF

  30. 15. What platelet count is needed before surgery?

  31. >50,000/mL

  32. 16. What platelet count is associated w/ spontaneous bleeding?

  33. < 20,000/mL

  34. 17. What platelet count suggests the prophylactic transfusion of platelets?

  35. <10,000

  36. 18. What is Virchow’s triad?

  37. Stasis, endothelial injury, and hypercoagulability

  38. 19. What is the most common cause of acquired hypercoagulability?

  39. Smoking

  40. 20. What is the most common inherited hypercoagulablestate?

  41. Factor V Leiden

  42. 21. What is the treatment for hyperhomocysteinemia?

  43. Vitamin B-12 and folate

  44. 22. Name the prothrombin gene defect causing spontaneous venous thrombosis?

  45. Prothrombingene defect G20210A

  46. 23. What is the normal life of a platelet?

  47. 7-10 days

  48. 24. What electrolyte is most likely to fall after the infusion of stored blood?

  49. Ionized calcium (citrate in stored blood binds serum calcium)

  50. 25. How long can PRBCs be stored?

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