Supplements For Your Nervous System
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Supplements For Your Nervous System. Cancer Wellness Center May 13, 2010 Anne Leavell, MS, RD, LDN, CDE Department of Neurology, Northwestern Medical Faculty Foundation. Supplements. Disclaimer:

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Supplements For Your Nervous System

Cancer Wellness Center

May 13, 2010

Anne Leavell, MS, RD, LDN, CDE

Department of Neurology, Northwestern Medical Faculty Foundation


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Supplements

Disclaimer:

Dietary supplementation should NOT be initiated without the supervision of a qualified physician. Check with your doctor before you begin.

Several of these supplements may have adverse effects


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Supplements

  • Vitamin E

    • Powerful antioxidant that reduces levels of free radicals and oxidative stress.

    • Protects against side effects: numbness, tingling, burning and pain

  • B Complex: B1(thiamine), B2(riboflavin), B3(niacin), B5(pantothenic acid), B6(pyridoxine), B7(biotin), B9(folic acid), B12(cobalamins)

    • B12 deficiency results in damage to protective covering of nerves

    • Decrease in pain (B1/B6/B12)

    • Folic acid (B9): maintenance of nerve cells


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Supplements

  • Acetyl-L-Carnitine

    • Neuroprotective properties

    • 2 small studies - limit chemotherapy induced neuropathy

    • More studies needed, effectiveness not established

  • Alpha lipoic acid

    • Benefit in diabetic neuropathy (less pain, burning and numbness)

    • Further studies needed for safety/efficacy of ALA in prevention/treatment of chemotherapy induced neuropathy


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Supplements

  • Glutamine

    • A neutral nonessential amino acid though to have neuroprotective effects (particularly with Paclitaxel)

    • More research needed to assess efficacy of glutamine

  • Glutathione

    • Tripeptide thought to prevent neurotoxicity

    • Efficacy seen in 50 advanced gastric cancer undergoing cisplatin-based chemotherapy


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Supplements

  • Magnesium/Calcium

    • Improvements in neurotoxicity following infusion

    • Caution: may cause diarrhea in large doses

    • Need more research to evaluate use as prevention/treatment of chemotherapy induced neuropathy

  • N-acetylcysteine (amino acid)

    • Powerful antioxidant

    • Animal studies have shown inhibition of diabetic neuropathy and protection against neuropathies caused by chemotherapy drugs


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Supplements

  • Omega-3 fatty acids:

    • High quantities in coldwater fish (salmon) and widely consumed for anti-inflammatory powers

    • Essential fatty acids and important component of cell membranes, myelin sheath that protects nerves

    • Studies show ability to reduce demyelination of nerves and neuropathic pain


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