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NIH NeuroBioBank: A Platform for Postmortem Brain Research. AFSP Forum February 28, 2014. Michelle Freund, PhD. What is the NeuroBioBank?. A federated brain and tissue repository network integrated by an IT system

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nih neurobiobank a platform for postmortem brain research
NIH NeuroBioBank: A Platform for Postmortem Brain Research

AFSP Forum

February 28, 2014

Michelle Freund, PhD

what is the neurobiobank
What is the NeuroBioBank?
  • A federated brain and tissue repository network integrated by an IT system
  • Brain and tissue repositories are now being supported with contracts (NIMH, NINDS and NICHD)
  • Focus on quality management, sharing, outreach
why are we doing this
Why are we doing this?
  • Increase the availability of tissue
  • Standardize quality metrics
  • Return data derived from banked tissues to public database
  • Opportunities for discovery have never been greater (genetics, iPSCs, and –omics,)
the nih neurobiobank for tissue access1
The NIH NeuroBioBank for tissue access
  • Neurobiobank Web Portal
  • Biospecimen inventory and access information
  • Information for the public
  • Standards for tissue and data
  • Standards for patient data, consent forms

Research

Community

Advocacy

Groups

Public &

Patient Populations

Brain Bank A

Brain Bank B

Brain Bank C

Brain Bank D

status of the nih neurobiobank
Status of the NIH NeuroBioBank
  • NeuroBioBankIT Portal is now live with information for the public, researcher site in development
  • Contracts were awarded to five Brain and Tissue Repositories on September 1, 2013

University of Miami, Deborah Mash

Harvard University, Francine Benes

Mt. Sinai, Harry Haroutunian

Sepulveda Research, RashedNagra

University of Pittsburgh, David Lewis

  • Efforts to centralize/standardize toxicology testing are underway
  • Solicitation for FY14 was issued and proposals are due Feb 18, 2014.
status of the neurobiobank
Status of the NeuroBioBank
  • Neurobiobank implementation will focus on:
    • Quality Management (uniform measures)
    • Increasing tissue and data access
    • Setting Standards (phenotype and tissue quality and characterization)
    • Outreach
slide9

Increase access to human tissues

  • Geographically distributed brain and tissue repositories
  • Increase public awareness/prospective donation
  • Partner with disease advocacy communities and local medical examiners to increase donation
  • Incentivize current bankers to increase diversity of donor pool
thank you
Thank You

NIH NeuroBioBank

NIMH

NINDS

NICHD

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