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Just enough biochemistry to be dangerous??. http://www.detoxi-pad.com/. Just enough biochemistry to be dangerous??. http://www.tahitiannoni.com/united_states/english/retail/store/research/index.html. Chapter 15. Design of metabolism. http://www.chem.uwec.edu/Chem454_S08/MetabolicchartBig.pdf.

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Just enough biochemistry to be dangerous??

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Just enough biochemistry to be dangerous
Just enough biochemistry to be dangerous??

  • http://www.detoxi-pad.com/


Just enough biochemistry to be dangerous1
Just enough biochemistry to be dangerous??

http://www.tahitiannoni.com/united_states/english/retail/store/research/index.html


Chapter 15
Chapter 15

Design of metabolism



G free energy recall
G, Free Energy, recall:


Just enough biochemistry to be dangerous


Just enough biochemistry to be dangerous
ATP state for the concentration of H+

  • the experimental value of K’eq = 2.23 x 105


Atp why
ATP-Why? state for the concentration of H+

repulsion

resonance

BUT,it’s kinetically stable


Other high energy compounds
Other “high energy compounds state for the concentration of H+


Just enough biochemistry to be dangerous

"High energy" substance state for the concentration of H+: a thermodynamically unstable substance whose hydrolysis or decomposition can be easily coupled to an unfavorable reaction. The arbitrary cut-off is~-10kJ/mol. There is no such thing as a "high energy bond" per se.


Coupled reactions
Coupled Reactions state for the concentration of H+

Free energies are additive; favorable rxns can drive unfavorable;e.g.sequential coupling


Just enough biochemistry to be dangerous

Sequential coupling state for the concentration of H+


Just enough biochemistry to be dangerous

Simultaneous coupling state for the concentration of H+

Example:Glucose to glucose-6-phosphate


Just enough biochemistry to be dangerous


Just enough biochemistry to be dangerous

  • the efficiency of the energy conservation under aerobic conditions is approximately 34%

  • Metabolism concerns how you get from here to there!!




  • Ion gradients
    Ion gradients compounds)


    Overall process
    Overall Process compounds)


    Recurring motifs in metabolism activated electron and functional group carriers
    Recurring Motifs in Metabolism compounds) “Activated” electron and functional group carriers


    Electron carriers
    Electron Carriers: compounds)

    H:-

    NAD+


    Electron carriers1
    Electron Carriers: compounds)

    FAD



    Carbon carriers
    compounds)Carbon” carriers


    Chemical reaction themes in metabolism
    Chemical Reaction compounds)“themes” in metabolism


    Chemical reaction themes in metabolism patterns
    Chemical Reaction compounds)“themes” in metabolism:Patterns


    Factors affecting metabolic rate
    Factors Affecting Metabolic Rate compounds)

    • Metabolism operates at a steady state.

    • Metabolites flow through the steady state



    Factors affecting metabolic rate2
    Factors Affecting Metabolic Rate compounds)

    • Metabolites flow through the steady state

    ATP




    Factors affecting metabolic flow or flux through pathways
    Factors Affecting Metabolic Flow or compounds)flux through pathways

    • Amounts of enzymes

    • Catalytic activity of enzymes

    • Availability of substrates


    Atp balance affects many metabolic pathways
    ATP Balance affects compounds)many metabolic pathways


    Atp balance affects many metabolic pathways1
    ATP Balance affects compounds)many metabolic pathways


    Control of metabolic flux j

    J compounds)

    J

    S

    A

    B

    CONTROL OF METABOLIC FLUX, J

    rate determining

    step

    P

    e.g. glucose

    pyruvate


    Control of metabolic flux j1
    CONTROL OF METABOLIC FLUX, compounds)J

    e.g. Substrate Cycling:

    See glycolysis (F-6-P to F1,6-BP)


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