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proteomics

proteomics. By RC7801A27. HISTORY. The term "proteomics" was first coined in 1997 to make an analogy with  genomics , the study of the  genes . Proteome = protein + genome

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proteomics

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  1. proteomics By RC7801A27

  2. HISTORY • The term "proteomics" was first coined in 1997 to make an analogy with genomics, the study of the genes. • Proteome = protein + genome • The word "proteome" is a blend of "protein" and "genome", and was coined by Marc Wilkins in 1994 while working on the concept as a PhD student.

  3. What is proteomics ? • Proteomics is the large-scale study of proteins, particularly their structures and functions. • It include large scale characterization of proteins . • Proteomics is very important because it helps in study of proteins which are responsible for phenotype of cells. • Aim of proteomics is to create a 3-d map of cell indicating where proteins are located. • The proteome is the entire set of proteins expressed by a genome, cell, tissue or organism and proteome is dynamic

  4. Identifying disease specific proteins ,compare protein expression of different proteomes,for instance cell of cancer and normal cells can be analysed Drug discovery, Drug targets proteomics Proteolysis,glycosylation,phosphorylation Expression proteomics Post translational modifications Proteome mining Protein-protein interactions Functional proteomics Structural proteomics Protein complexes,organellecomposition,subproteome composition Protein functions, analyse protein network, identifying novel proteins

  5. Application of proteomics

  6. PROTEIN BASED PRODUCTS DISCOVERED

  7. Neutraceutical proteins=proteins with therapeutic valuesfor example Lactose free milk, Curd used as a probiotic as it contains beneficial bacteria colonising the intestinal tract Whey protein Infant food formulation is done

  8. Therapeutic uses of whey protein The search has shown that : It results in the elevation of a tripeptide called glutathionine in cells It is a reducing compound leading to detoxification of xenobiotics and protection of cells against oxygen intermediates and free radicals The constituents of whey are:

  9. Novel proteins Since proteins are the main molecules which provide stimulus to immunity so proteins are engineered having minimum deleterious effects. The specific sequence of amino acids in the protein which stimulate immune response are known as epitopes. Recombinant vaccines based on epitopes are made with optimal design to make a safe vaccine These days subunit vaccine against Hepatitis b virus (hbv) infection

  10. Want to be a good athlete!!!!!!!use And BCCA BCCA are branched chain amino acids released during exercise from muscle the carbon part used as a fuel and nitrogen part makes alanine which goes to liver where it turns into glucose for energy so athletes these days take BCCA before and after exercised

  11. conclusion • Study of proteins is very important because: • They have lot of functions as mentioned in ppt • One main important reason is that relation between proteins and genes is non linear • Why ? • Because mRNA analysis does not provide relation about protein expressions • Formation of mRNA is only first step in protein synthesis now this mRNA undergoes various post transcriptional modifications which leads to : • Generation of various proteins from a single gene • So more proteins are their and their expressions should be studied to explore new discoveries

  12. thankyou

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