Can Addiction Research Be Trusted?. Introducing EBAM* (*Evidence Based Addiction Medicine). Stewart B. Leavitt, PhD, Editor Addiction Treatment Forum Sponsored by an educational grant from Mallinckrodt Inc. EBAM Guides Available. “Can Addiction Research Be Trusted?” – report
Introducing EBAM*(*Evidence Based Addiction Medicine)
Stewart B. Leavitt, PhD, EditorAddiction Treatment Forum
Sponsored by an educational grant from Mallinckrodt Inc.
Trepanation once was a “scientific cure” formental illness.
EBAM approaches allow you to respond more convincingly to the following questions….
Surveys of research have found startling results…
Systematic Reviews / Meta-Analyses of RCTs.
Randomized Controlled Trials (RCTs).
Results: No significant differences in mean age at death or in years survival after exposure.
Conclusion: Mummy’s curse was an urban legend.
Publication Bias – Trials with “positive” results are more likely to be submitted and published more quickly.
Patient Selection – Who was excluded or included? Were groups equivalent?
Subject Management – Were groups treated exactly the same, except for the intervention under study?Sources of Potential Bias - 1
Ling et al. Arch Gen Psychiatry. 1996;53:401-407.
In the 8 mg/d BUP vs 80 mg/d Methadone trial –
When too many people are involved in a research article, it reminds us that…
“A camel is a horse that was designed by a committee.”
©1980, David Sinclair, PhD - used by permission
“We have met the enemy and he is us!” - Pogo (Walt Kelly)