Conclusions. Summary Findings. Acknowledgements. Risks, Rewards and the Double-Edged Sword: Views of Pharmacogenetic Testing and Research in the Alaska Native/American Indian Community
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Risks, Rewards and the Double-Edged Sword: Views of Pharmacogenetic Testing and Research in the Alaska Native/American Indian Community
Jennifer Shaw, PhD1, Renee Robinson, PharmD, MPH1, Helene Starks, PhD, MPH2, Wylie Burke, MD, PhD2 and Denise Dillard, PhD11Southcentral Foundation, Anchorage, AK, 2University of Washington, Seattle, WA
PGx is potentially helpful and harmful . . .
. . . but PGx could be acceptable and useful IF
8 contingencies are met:
“…with the trial-and-error dosing, you have constant monitoring of [Warfarin]….if you’re able to do genetic testing and you can narrow down the variability, that could help decrease the unwanted side effects.”
“…prescribing the wrong medication, that costs a lot of time and the medication itself…”
“It sounds like [PGx] testing could help a few people whenmaybe that money could be spent to help a lot more people.”
“…there's always that fine line between religion and, you know, science.”
“…to have that kind of research [here] is a very good thing…why don’t we lead the way… Alaska leading the way in this genetic thing would be a good door to open for a hospital.”
n = 7
n = 2
n = 1
“So would it benefit the entire population? Because you don't want to have that ‘us against them.’”
This project is funded by the National Institute of General Medical Sciences Grant #RFA-GM-10-001.
“I think [participation in PGx research] should be voluntary, but the first thing I start thinking of is exactly who would be trying to look at your health….there is, for me, a lot of privacy concerns.”
“…you know a lot of the modern ways of life that come into the villages and then you get a lot of obesity, a lot of diabetes--a lot of cancer.”
n = 1
n = 3