Three Traps to Avoid & Bioinformatics Advantage. 1.) In the Discovery Phase Its ok to “Fish” for significant relationships in your data (i.e. look at correlations across all my variables and then report the significant ones that you find). .
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Its ok to “Fish” for significant relationships in your data (i.e. look at correlations across all my variables and then report the significant ones that you find).
With alpha=0.05, after 20 correlations you can expect to make a spurious correlation. Data Mining is a bioinformatics tool, you just need to know the rules.
I can only afford to have 25 patients in this first trial, I don’t need a “power” calculation.
Even when you know how many patients you can afford, changing the design slightly or balancing the study arms differently can increase your ability to observe true differences.
Model various scenarios to optimize your design.
Having “enough” patients in each arm is most important to demonstrate efficacy and safety.
Reduce Safety Risks and
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