Research Integrity: The Importance of Data Acquisition and Management. Randall Reed, Ph.D. , Director, Center for Sensory Biology Professor , Department of Molecular Biology & Genetics , Neuroscience, and Otolaryngology , Head & Neck Surgery. Disclosures.
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Research Integrity:The Importance of Data Acquisition and Management.
Randall Reed, Ph.D.,
Director, Center for Sensory Biology
Professor, Department of Molecular Biology & Genetics, Neuroscience, and Otolaryngology, Head & Neck Surgery
No Relevant Financial Relationships
with Commercial Interests
Genetic and Genomic Information
R. Reed PNAS 1981
Imaging and Visualized Information
The sheer Volume of data that supports/incorporated into publications has accelerated by many orders of magnitude!!
A Time Line….
Present Data at
Collect More Data
Repeat Experiment – Get Good Data for Publication
Make Draft of
Give to PI to
PI Excited: Tell Student Time to Write His Paper
See Data at
Time - YEARS
PI asks Student if Better Images Exist
PI Gets Draft Figures
PI Improves + Approves Final Figs
Time - WEEKS
What’s Wrong with these Scenarios??
Remove graininess with blur
Adjust levels and contrast
Clean up “background”
(AcTubwt)AD994 AcTub single a.tif92.110um
(AcTub KO)AD996 AcTub single a.tif92.110um
(i7/ac3 wt)AD994 I7 AC3 projb.tif92.110um
(i7/ac3 KO)AD996 I7 AC3 projb.tif92.110um
(i7/slp3 wt)AD994 I7 SLP3 projb.tif92.110um
(i7/slp3 KO)AD996 I7 SLP3 projb.tif92.110um
Allows permanent connection between published materials
and the original source data!!