Synthesis of chalcones starting materials for the synthesis of parasite targeted compounds
This presentation is the property of its rightful owner.
Sponsored Links
1 / 10

Synthesis of Chalcones: Starting Materials for the Synthesis Of Parasite-targeted Compounds PowerPoint PPT Presentation


  • 195 Views
  • Uploaded on
  • Presentation posted in: General

Synthesis of Chalcones: Starting Materials for the Synthesis Of Parasite-targeted Compounds. Sarah Canch é Lee Lab Group. Malaria, Leishmaniasis, and Trypanosomiasis. Diseases caused by protozoan parasites transmitted by mosquitoes, sand flies, and tsetse flies. Some Symptoms. Malaria:

Download Presentation

Synthesis of Chalcones: Starting Materials for the Synthesis Of Parasite-targeted Compounds

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Synthesis of chalcones starting materials for the synthesis of parasite targeted compounds

Synthesis of Chalcones: Starting Materials for the Synthesis Of Parasite-targeted Compounds

Sarah Canché

Lee Lab Group


Malaria leishmaniasis and trypanosomiasis

Malaria, Leishmaniasis, and Trypanosomiasis

  • Diseases caused by protozoan parasites transmitted by mosquitoes, sand flies, and tsetse flies


Some symptoms

Some Symptoms

Malaria:

  • Dry cough, fever, headache, fatigue, body aches

    Leishmaniasis:

  • Skin sores, fever, visceral swelling

    Trypanosomiasis:

  • Muscle and joint aches, fever, confusion, slurred speech


Widespread problem

Widespread Problem:

Malaria:

  • 1-3 million deaths per year

    Trypanosomiasis:

  • 50,000 to 70,000 cases per year

    Leishmaniasis:

  • 10-15 million have it, with 1.5 to 2 million new cases per year

  • Treatment for these diseases is expensive and not always effective

  • Parasites can develop resistance

  • Need to make treatments that are more affordable and effective


Pentamidine and furamidine

Pentamidine and Furamidine

  • Molecule currently being used to fight parasitic diseases

    • Destroys parasite DNA

  • Molecule that has been proven to help fight parasitic diseases.

  • Goal: Make a molecule similar to this

    • Increase potency

    • Cheaper to produce

Pentamidine

Furamidine


Synthetic pathways

Synthetic Pathways

Diarylpyrazolediamidine Synthesis

Thioxopyrimidine Synthesis


How to synthesize chalcones method 1

How to synthesize chalcones: Method 1

To make…

86% yield

94% yield


Method 2

Method 2

65% yield

6 M NaOH

MeOH

Reflux

94% yield

  • Methanol added to flask

  • Reaction mixture heated to reflux

  • 1 M NaOH added to the mixture

  • Solid forms

  • Solid collected by vacuum filtration


What i learned

What I learned

  • Run an NMR

  • Run an IR

  • Perform TLC analysis

  • ChemDraw

  • Rotovap


Acknowledgements

Acknowledgements

  • Dr. Moses Lee

  • Drs. Toni Brown & Hilary Mackay

  • Kristin Dittenhafer

  • Lee Lab Group

  • REACH

  • Hope College Chemistry Department

  • Conjura Pharmaceuticals, LLC


  • Login