Intro. To Cardiovascular Pharmacology. Vasoactive Peptides & Inhibitors Dec. 2008. Introduction. Cardiovascular Reflex Regulation Overall coordination and integration of the CVS is accomplished primarily by the ANS. Major aspects of CV regulation: BP = CO x TPR
BP = CO x TPR
CO = HR X SV
Ang converting enzyme (ACE)
Biologic activity: Ang II>Ang III>Ang I
Sites of Action of Drugs ThatInhibit the RAS
Captopril SH No
Enalapril* COOH Yes
Lisinopril COOH No
Fosinopril PO3 Yes
Ramipril COOH Yes
*Enalapril is converted to enalaprilat by an esterase.
constriction of efferent afterioles. Treatment with an ACE inhibitor dilates
efferent arterioles and lowers the driving force for glomerular filtration.
Plasma volume expansion