LES HADRONS  POUR LA SANTE
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LES HADRONS POUR LA SANTE '. Ugo Amaldi Università di Milano Bicocca e Fondazione TERA. The starting point. 1895 Discovery of X-rays. Wilhelm Conrad Röntgen (1845 – 1923). CT Computer Tomography. target. Linac for the therapy with X-rays. e -  X target. 270  bending magnet.

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Les hadrons pour la sante

LES HADRONS POUR LA SANTE'

Ugo Amaldi

Università di Milano Bicocca e Fondazione TERA


The starting point

The starting point

1895

Discovery of X-rays

Wilhelm Conrad Röntgen

(1845 – 1923)


Les hadrons pour la sante

CT

Computer Tomography


Linac for the therapy with x rays

target

Linac for the therapy with X-rays

e- X target

270 bending magnet

Flattening filters

3 GHz Electron linac

Ion chambers

Multileaf collimator

Maximum field size

40  40 cm2

Maximum dose rate:

~ 5 Gy/min


Linac multileaf collimator and tps

LINAC, multileaf collimator and TPS


Les hadrons pour la sante

1930

Ernest Lawrence invents the cyclotron

M. S. Livingston e E. Lawrence

With the 25 inch cyclotron


Les hadrons pour la sante

1975

450 GeV protons

SPS at CERN

1981- SPS is transformed in a proton-antiproton collider

Carlo Rubbia and Simon van der Meer


Les hadrons pour la sante

gluon

Main results of 30 years of research (1950-1980)

Quarks are the constituents of atoms together with electrons

They are bound by gluons to form

HADRONS


Hadrons penetrating in matter

Hadrons penetrating in matter

4500 MeV CARBON

(PSI – Villigen)


Comparison of x rays imrt with protons

Comparison of X rays (IMRT) with protons

Between eyes

In the abdomen

In the brain


Rbe radiobiological effectiveness

RBE=Radiobiological Effectiveness

In a cell a carbon ion leaves 23 times more energy than a proton

The ‘quality’ of the deposited energy

is different

Carbon ions are effective on “radio-resistant” tumours


Number of potential patients

Number of potential patients

Therapy with X-rays (5 – 20 MeV)

20'000 patients/year in 10 million inhabitants

Protontherapy

Category A: 1% of X-ray patients = 200 patients/year in 10 M

Category B: 10% of X-ray patients = 2'000 patients/year in 10 M

Therapy with carbon ions of radioresistant tumours

10% of X-ray patients = 2'000 patients/year in 10 M


Hadrontherapy in the world

NORTHEAST PROTON THERAPY CENTER

NPTC of Mas General Hospital

Boston (2001)

protons ( 235 MeV)

cyclotron (IBA)

2 gantries + 2 fixed beams

Midwest Proton Radiaton Institute

Bloomington (IN) (2003)

protons ( 210 MeV) from cyclotron

1 gantry + 1 fixed beam + 1 experimental

LOMA LINDA

UNIVERSITY CENTER

Los Angeles (1992)

protons ( 250 MeV) from synchrotron

3 gantries + 2 fixed beams

M.D. Anderson Cancer Center

Houston (TX) (2004)

protons ( 235 MeV) from cyclotron

3 gantries + 1 fixed beam + 1 experimental

Hadrontherapy in the world


Hadrontherapy in the world1

TSUKUBA CENTRE

Ibaraki (2001)

protons ( 270 MeV) synchrotron (Hitachi)

2 gantries

2 beam for research

WAKASA BAY PROJECT

by Wakasa-Bay Energy Research Center

Fukui (2002)

protons ( 200 MeV) synchrotron (Hitachi)

1 h beam + 1 v beam + 1 gantry

KASHIWA CENTER

Chiba (1998)

protons ( 235 MeV)

cyclotron (IBA – SHI)

2 Gantries + 1 hor. beam

HYOGO MED CENTRE

Hyogo (2001)

protons ( 230 MeV) - He and C ions ( 320 MeV/u) Mitsubishi synchrotron

2 p gantries + 2 fixed p beam + 2 ion rooms

HEAVY ION MEDICAL ACCELERATOR

HIMAC of NIRS (1995)

He and C ( 430 MeV/u) 2 synchrotrons

2 h beams + 2 v beams

SHIZUOKA FACILITY

Shizuoka (2002)

protons cyclotron or synchrotron

2 gantries + 1 h beam

Hadrontherapy in the world


Hadrontherapy in the world2

Hadrontherapy in the world

“Hospital-based” centres of protontherapy

three in USA

two in China

one in Korea

one in Germany

one in Switzerland


Swiss centre at psi villigen

Swiss Centre at PSI - Villigen

PSI Villigen

Optis – eye tratment: 3800 patients

PSI “gantry”: 150 patients


Psi proscan

PSI: PROSCAN

Superconducting cyclotron of ACCEL (Germany)


European projects with carbon ions

European projects with carbon ions

GSI – Darmstadt

Pilot project

200 patients


Hicat heidelberg

HICAT - Heidelberg

72,5 Meuro

Ready in 2006


Les hadrons pour la sante

TERA PROJECT

  • A linac IH (GSI) in the ring

  • Compact lines

  • Gantries in phase 2

PIMMS

(Proton Ion Medical Machine Study)

CERN – TERA – Med-Austron

Proton Ion Medical Machine Study

PIMMS at CERN 1996-2000


Les hadrons pour la sante

Site

Announced by Italian

Government on 20.1.03

Pavia

Close to the University

Hospital San Matteo

CNAO Foundation:

Policlinici di Milano e Pavia, Istituto Neurologico Besta, Istituto Europeo di Oncologia, Istituto dei Tumori, TERA

TOTAL: 40,3 Meuro

Ready in fall 2007


Les hadrons pour la sante

5

Pavia Centre

CNAO

Foundation

4

3

2

1


Les hadrons pour la sante

CNA = Centro Nazionale di Adroterapia for p and 12C

Phase 1


Magnets

Magnets


Prototipo di quadrupolo

Prototipo di quadrupolo

In collaborazione

con i Laboratori

di Frascati dell’INFN


General plan

General plan

Parking lot


Les hadrons pour la sante

Entrata principale ed edificio del sincrotrone

STUDIO CALVI s.r.l. Ingegneria e Architettura, Aprile 2003


Enlight

ENLIGHT

EUROPEAN NETWORK

ESTRO, EORTC, CERN, GSI

Centre of Heidelberg

Centre of Pavia

Centre of Wiener-Neustadt

Centre of Lyon

Centre of Stockholm

European

Network

for LIGHt-ion

Therapy


Les hadrons pour la sante

1896-1897

Europa: primi usi dei raggi X in terapia

Pavia

Heidelberg

2006-2007

Europa: due centri ospedalieri di adroterapia con ioni carbonio


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