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Current Topics in Medical Physics Research. Xiaoming Zheng, PhD. School of Dentistry and Health Science Chengdu, China, 2009. Current Research Interests . Image reconstruction algorithms Scatter and resolution corrections Image quality assessment Clinical image analysis

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Current topics in medical physics research l.jpg

Current Topics in Medical Physics Research

Xiaoming Zheng, PhD.

School of Dentistry and Health Science

Chengdu, China, 2009


Current research interests l.jpg
Current Research Interests

  • Image reconstruction algorithms

  • Scatter and resolution corrections

  • Image quality assessment

  • Clinical image analysis

  • Computer aided diagnosis

  • Radiation detectors









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Images Reconstructions

  • Iterative Reconstruction: Rescaled Block Iterative Algorithm including attenuation, scatter, and distance resolution compensation. Parameters tested: iteration 1,3,5,7,10 and post Gaussian filter FWHM 0,1,2,3,4 pixels

  • Filtered Back-Projection: Parameters tested: Butterworth filter cut-off frequencies: 0.10, 0.15, 0.20, 0.25 and 0.30 pixel-1


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Reconstructed images

FBP

Iterative


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Human and Numerical Observer Image Quality Studies

  • Human observer study using receiver operating characteristics

  • Numerical observer employing an ideal observer model.









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Before Correction Imaging

After Correction




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Radiation Dose Optimization in CT Imaging

  • Biological effect of ionizing radiation

  • Cancer rate vs radiation dose

  • Radiation dose reduction: image quality vs radiation dose

  • Technical parameters: kVp, mAs, etc.


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CT Scan Parameters and Dose Index Imaging

Brain

Abdomen






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Computer Assisted Diagnosis Imaging

  • Provide second opinion to radiologists.

  • FDA approved systems include breast and lung cancer detections.

  • Image processing

  • Image data base

  • Artificial intelligence.



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Radiation Detectors Imaging

  • Room temperature Semiconductor Detectors: Materials and mechanisms

  • Magnetic resonance coils designs.


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Scintillator-based gamma camera Imaging

Detector head

(GE Medical Systems)


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CZT / NaI comparison Imaging

ELGEMS CZT pixilated

small field imager

Anger camera (NaI)

Test image

Thyroid phantom


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Semiconductor - CZT Imaging

g

CdZnTe: Gamma rays create electron/hole pairs. The gamma energy level is proportional to the electrical current.

X

CdZnTe (CZT)

E

h

+

e

-





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New Imaging Systems Imaging

  • New detector technology.

  • Optical imaging: visible, ultraviolet, inferred.

  • Molecular imaging: PET, fMRI, Optical

  • Hybrid imaging systems.

  • T Herts imaging.




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Thickness of tissue probed Imaging

30 mm 100mm 1mm 1cm 10cm

l

400 nm

800 nm

1600 nm

10 mm

100 mm

Confocal/ multi-photon microscopy

Diffuse optical tomography

Optical coherence tomography

Thermography

THz imaging



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Medical Physics Topics? Imaging

  • Treatment of depression: Transcranial magnetic stimulation.

  • Killing of cancer cells: Electric field on biological molecules.


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