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Tumor viruses. Tumor viruses. Viruses can cause beningn or malignant tumors in many species of animals A few viruses are associated with human tumors. Malignant transformation of cells. Altered morphology Altered growth control Altered cellular properties Altered biochemical properties

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tumor viruses1
Tumor viruses
  • Viruses can cause beningn or malignant tumors in many species of animals
  • A few viruses are associated with human tumors
malignant transformation of cells
Malignant transformation of cells
  • Altered morphology
  • Altered growth control
  • Altered cellular properties
  • Altered biochemical properties

can be induced by tumor viruses

tumorigenesis
Tumorigenesis
  • Provirus:thegenesenterthecellbyinfectionbytumorvirus
  • Oncogene: alreadypresent in thecell

cellularoncogenes(c-onc) areactivatedbyvirusestooverproducethegrowthfactors

  • Tumorsupressor gene (p53):inactivation of this gene
  • Micro-RNA genes
tumor viruses2
Tumor viruses
  • Human T-cell lymphotropic virus(HTLV-I):
    • Adult acute T-cell lymphocytic leukemia (ATLL)
    • No viral oncogene (different from animal tumor retroviruses)
    • Tax and rex regulatory genes
tumor viruses3
Tumor viruses
  • Humanpapillomavirus:
    • E6 and E7 genes
    • Encodeproteinsthatinterferewith p53 andRb(retinoblastom) tumorsupressorgenes
    • Mostlythe HPV(especiallyhighlyoncogenictypes 16 and 18) is integratedintocellular DNA
tumor viruses4
Tumor viruses
  • EBV:
    • İnduces B cell proliferation
    • Activation of a cellular oncogene
    • Burkitt lymphoma: c-myc oncogene in chromosome 8 is translocated to14 chromosome where large amounts of c-myc RNA are synthesized.
tumor viruses5
Tumor viruses
  • HBV:
    • Primer hepatocellular carcinoma:integration may activate an oncogen
  • HCV:
    • Chronic infection
  • HHV-8:
    • ?
animal tumor viuses
Animal tumor viuses
  • DNA Viruses:
    • SV40
    • Adenovirus
    • Poxviruse
  • RNA viruses
    • Retroviruses

No evidence that they cause tumors in humans

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