DERMATOLOGIC MANIFESTATIONS OF GASTROINTESTINAL DISEASES

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DERMATOLOGIC MANIFESTATIONS OF GASTROINTESTINAL DISEASES

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1. DERMATOLOGIC MANIFESTATIONS OF GASTROINTESTINAL DISEASES Micheline Maamari Chalouhi,MD

2.

4. ESOPHAGUS Dysphagia 1-Diseases extending to the esophagus 2-connective tissue diseases 3-cancer

5. Candida

6. Pemphigus vulgaris Autoimmune Sore throat, dysphagia

7. Systemic sclerosis Crest Lower 2/3 90% Premature fullness,reflux dysphagia,abdominal pain

8. Plummer vinson (paterson kelly) syndrome Postcricoidal web Koilonychia Sore tongue angular stomatitis Iron deficiency

9. cancer Tylosis

10. Gastrointestinal Bleed Hereditary hemorrhagic telangiectasias AD Vascular dilatation:oral, nasal, GI Epitaxis(1) Severe GI bleed (2) first decade

11. Gastrointestinal Bleed Ehlers-Danlos Type 3 & 4 collagen defect

12. Gastrointestinal Bleed Pseudoxathoma elasticum

13. Gastrointestinal Bleed Kaposi sarcoma(HHV8) Endothelial & lymphoreticular cells GI: 50-80% cutaneous 100% oral stomach,esophagus, SI

14. Polyposis Gardner’s syndrome AD(defect ch 5) Epidermoid cysts,fibromas, lipomas,osteomas adenomatous polyps colon Carcinoma

15. POLYPOSIS Canada cronkhite syndrome Macular hyperpigmentation Alopecia(rapid onset) Nail atrophy (onycholysis, triangular deformity)

16. POLYPOSIS Cowden disease AD Skin tags,acral keratoses,oral fibroma Breast,thyroid,cervical,colon cancer

17. POLYPOSIS Muir-torre Sebaceous gland tumors Visceral malignancies(colon,kidney,uterus…)

18. POLYPOSIS Peutz-jegher’s syndrome AD Hamartomatous polyps(jejunum) Lips,buccal mucosa,gingiva,.. Ovary,thyroid,cervix CA

19. INFLAMATORY BOWEL DISEASES pyoderma gangrenosum 50%PG have UC 10% UC have PG Severity & extent of ulceration are Linked to the activity of the disease

20. INFLAMATORY BOWEL DISEASES Granulomas

21. INFLAMATORY BOWEL DISEASES Erythema nodosum

22. INFLAMATORY BOWEL DISEASES Aphtous ulcers

23. PANCREATITIS acute

24. pancreatic fat necrosis

25. Signs of specific GI tumors Stomach Pernicious anemia Vitiligo Alopecia areata

26. Signs of specific GI tumors Small bowel Carcinoid Release of serotonin & bradykinin Hepatic metastasis Paroxysmal Telangiectasia, plethora….

27. Signs of specific GI tumors Large bowel Paget Intense pruritis Glandular adnexal ca or regional internal ca

28. Signs of specific GI tumors Glucagonoma APUD Necrolytic migratory erythema

29. Paraneoplastic signs Dry skin Eczema craquele malabsorption

30. Paraneoplastic signs Dermatomyositis Early sign Life saving

31. Paraneoplastic signs Acanthosis nigricans

32. Paraneoplastic signs sister Mary Joseph nodule

33. Paraneoplastic signs Lesser trelat

34. Thank you……..

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