Large scale fluid structure interaction modeling of the human brain
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Computer Simulation. Live patient MRI. HYDROCEPHALUS. DRUG DELIVERY. Catheter. Cortex. TECHNICAL APPROACH: MOVING GRID CODE. Post – Processing. Solvers. MR Imaging. Grid Generation. Image Reconstruction. Novel Moving Grid Code + FLUENT. 3-D model of the ventricular system

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Large-scale Fluid Structure Interaction Modeling of the Human Brain

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Large scale fluid structure interaction modeling of the human brain

Computer Simulation

Live patient MRI

HYDROCEPHALUS

DRUG DELIVERY

Catheter

Cortex

TECHNICAL APPROACH: MOVING GRID CODE

Post –

Processing

Solvers

MR

Imaging

Grid

Generation

Image

Reconstruction

Novel Moving

Grid Code

+ FLUENT

3-D model of the ventricular system

and half of the subarachnoid space.

3-D model of the solid brain

(white and gray matter).

Velocity magnitude (m/sec)

Large-scale Fluid Structure Interaction Modeling of the Human Brain

Laboratory for Product and Process Design, Director A. A. LINNINGER

Prime Grand Support: NSF, Susman and Asher Foundation

  • Prediction of large deformations of the brain parenchyma based on Fluid-Structure Interaction modeling.

  • Coupling of the brain parenchyma, vascular and ventricular system in the human brain.

  • The therapeutic approach for hydrocephalus treatment is very brutal (shunting) and many revisions are needed.

  • Ultimate goal: precise model of human brain dynamics to design treatments without in vivo test.

  • Data from Magnetic Resonance Imaging.

  • Use of MRI reconstruction tools for generation of 3D patient specific brain geometry.

  • Introduction of the geometry to Finite Volumes or Finite Elements advanced solvers.

  • Post processing of the obtained results.

  • 3D geometric reconstruction of patient-specific brain dimensions based on MRI data

  • 3D patient-specific dynamic analysis of CSF flow in the human brain

  • Optimal Drug Delivery to the Human Brain.

  • Feedback control systems to better treat Hydrocephalus.


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