A peptide mimicking vgll4 function acts as a yap antagonist therapy against gastric cancer
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A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer PowerPoint PPT Presentation

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A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Feng Junnan. Cancer Cell 25, 166–180, February 10, 2014. Introduction. Function Study. M echanism Study. Structural Study. Clinical Study. Experimental design. VGLL4 i s a p otential

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A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

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A Peptide Mimicking VGLL4 Function Actsas a YAP Antagonist Therapy against Gastric Cancer

Feng Junnan

Cancer Cell 25, 166–180, February 10, 2014


Function Study

Mechanism Study

Structural Study

Clinical Study

Experimental design

VGLL4 is a potential

tumor suppressor

How does VGLL4 function?

Key residues for

VGLL4-TEAD4 complex formation?

A Rationally Designed Peptide “Super-TDU”


Result 1:

VGLL4 Is a Potential Tumor Suppressor in Human Gastric Cancer


Result 2:

VGLL4 Suppresses GC Growth in Vitro by Targeting YAP-TEADs


Result 3:

VGLL4 Functions through Competing with YAP for TEAD4 Binding


Result 4:

TDU Domains Alone Are Sufficient for VGLL4 Function of Inhibiting YAP


Structural Study

Result 5:

A Rationally Designed Peptide " Super-TDU " Potently Inhibits GC Growth


1、Inhibits GC Growth

2、Pharmacological Evaluation of the Super-TDU

3、Inhibits Tumor Growth of Human Primary GC

4、 Inhibits GC Tumor Growth in the H. pylori-Infected Mouse Model



cancer cell

overactive YAP


  • Important signal pathway-- Hippo

  • Novel therapy against cancer -- Physical antagonist

  • Simple technologies , rigorous design.


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