Hypolipidemic agents in chronic therapy. A compliance study in the ASSET cohort. The issue. In the 2000-2004 five years period, the Italian SSN invested cumulatively over €3.3. billion to fund the prescribing of statins in primary care .
Hypolipidemic agents in chronic therapy.
A compliance study in the ASSET cohort
€ 1 billion/ year
Evaluate the % of persistent and compliant subjects twelve month after initiating statins’ treatment
Persistence:rate of subjects without an interval between 2 consecutive Rx < DDDs prescribed + 30 days
Compliance:rate of persistent subjects with total number of DDDs prescribed/365 > 80%
KEY ASSUMPTION: 1 pill = 1 DDD
Diabetes and high blood pressure identified by the use
of concomitant medications (ATC A10 and C)
 Agenzia Italiana del Farmaco AIFA. L’uso dei farmaci in Italia. OSMED reports 2000-2004. Available online at: http://www.agenziafarmaco.it/aifa/servlet/section.ktml?target=&area_tematica=ATTIVITA_EDITORIALE§ion_code=AIFA_PUB_RAP_OSMED&cache_session=true
 Favato G and Print C (2008). 2002 mortality rate for coronary heart disease in Italy: a statistical outlier or a sentinel event? Heart, Feb 27. Available online at: http://heart.bmj.com/cgi/eletters/94/2/178#8103
 Majeed A, Aylin P, Williams S, Bottle A, Jarman B (2004). Prescribing of lipid regulating drugs and admissions for myocardial infarction in England. BMJ, 2004 329:645, doi: 10.1136/bmj.329.7467.645
 Lucioni C, Mazzi S, Cerra C et al (2006), Uno studio di Drug Utilisation delle statine nella recente prassi terapeutica italiana. PharmacoEconomics-IRA. 8(1): 3-17
 Abraha I, Montedori A, et al (2003), Statin compliance in the Umbrian population. European Journal of Clinical Pharmacology. Vol. 59 Numbers 8-9.
 Poluzzi E, Strahinja P, Lanzoni M, Vargiu A, Silvani M C, Motola D, Gaddi A, Vaccheri A, Montanaro N (2007). Adherence to statin therapy and patients’ cardiovascular risk: a pharmacoepidemiological study in Italy. Eur J Clin Pharmacol
 Favato G, Mariani P, Mills RW, Capone A, Pelagatti M, et al. (2007) ASSET (Age/Sex Standardised Estimates of Treatment): A Research Model to Improve the Governance of Prescribing Funds in Italy. PLoS ONE 2(7): e592. doi:10.1371/journal.pone.0000592
 Larsen et al.(2002), High persistence of statin use in a Danish population: compliance study 1993-1998, British Journal of clinical Pharmacology, Vol 53, 4: 375-378