1 / 17

Carbohydrate Metabolism: Mono/disaccharide Metabolism

INTER 111: Graduate Biochemistry. Carbohydrate Metabolism: Mono/disaccharide Metabolism. Monosaccharide & Disaccharide Metabolism. Glycogen . R5P. Disaccharides. Glucose. fructose galactose. NADH + H + and ATP. Pyruvate. O 2. H 2 O. aerobic conditions. NADH + H + and FADH 2

ellard
Download Presentation

Carbohydrate Metabolism: Mono/disaccharide Metabolism

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. INTER 111: Graduate Biochemistry Carbohydrate Metabolism:Mono/disaccharide Metabolism

  2. Monosaccharide & Disaccharide Metabolism Glycogen R5P Disaccharides Glucose fructose galactose NADH + H+ and ATP Pyruvate O2 H2O aerobic conditions NADH + H+ and FADH2 and CO2 Electron transport Oxidative phosphorylation Acetyl CoA citric acid cycle ATP ADP + Pi

  3. Artificial sweeteners • Sugar substitute: food additive to duplicate sugar taste but with less food energy • Sweetness of compounds many fold greater than glucose or sucrose • Ongoing controversy over health risks

  4. Artificial sweeteners saccharin aspartame • Saccharin • discovered in 1879 • 300X sweeter than sucrose • no food energy • Aspartame • Discovered in 1965 • 180X sweeter than sucrose

  5. Fructose metabolism • Typical Western diet contains 50 g fructose/day • Fructose found in corn syrup, fruits, and honey • Insulin-independent SUCROSE

  6. Phosphorylated products of fructose and their cleavage • Either hexokinase or fructokinase can covalently modify fructose. • Hexokinase phosphorylates glucose rather than fructose, unless [fructose] is unusually high. • Fructokinase found in particular tissues Glycolysis Fructose metabolism

  7. Phosphorylated products of fructose Glycolysis Fructose metabolism

  8. Lens, kidney, nerve Seminal vesicles Sorbital metabolism

  9. Lactose Synthesis Stimulated by prolactin • Occurs in ER and Golgi bodies of human mammary glands Lactose synthase

  10. Galactose metabolism

  11. Galactose metabolism

  12. Galactosemetabolic disorders Classic galactosemia Uridyltransferase deficiency Autosomal recessive disorder (1 in 23,000 births)

More Related