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Rational management of epilepsy in developing countries: requirements and resources. Prof. Paulo R M de Bittencourt, MD, PhD Co-chairman, Subcommission on Therapeutic Needs in Emerging Countries ILAE Commission on Therapeutic Strategies. Epilepsy in Latin America.

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Rational management of epilepsy in developing countries requirements and resources l.jpg

Rational management of epilepsy in developing countries: requirements and resources

Prof. Paulo R M de Bittencourt, MD, PhD

Co-chairman, Subcommission on Therapeutic Needs in Emerging Countries

ILAE Commission on Therapeutic Strategies


Epilepsy in latin america l.jpg
Epilepsy in Latin America requirements and resources

  • Reliable health statistics, cost evaluation studies not available

  • Health systems mixed, private participation

  • Cost similar to average developed countries

  • Investigation and therapy cheaper

  • Disease-related costs higher

  • Greater disability and death


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The cost of epilepsy requirements and resources

  • Active versus inactive or remission, early costs higher

  • Total in UK: US$ 6000-8000 per year

  • Direct, related to medical care

    • 20-30%, in UK, USA, Australia: US$ 1000-3000 per year

  • May be applicable to other countries

  • Indonesia: direct cost is US$ 1000 per year

  • Indirect costs not calculated

  • Beran and Pachlatko, 1995


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Population, poverty and development requirements and resources


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Doubling times of world population requirements and resources

  • Developed countries 809 years

  • Less developed 42 years

  • Western, Middle Africa 20-30 years

  • Latin America/Caribbean upper 20s-130 years

  • Brazil 45 years

  • Mexico 36 years

    www.prb.org


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Human Development Index requirements and resourceswww.undp.prg/hrdo

  • Brazil: 8th largest industrial nation: 63rd (1995), 74th (1998)

  • Barbados 30th

  • Argentina, Antigua, Barbuda, Chile, Uruguay below 40th

  • 40-50th: Caribbean, Latin American, East European

  • Mexico 55th, Cuba 56th, Venezuela 65th, Colombia 68th

  • Brazil with Lybia, Kazakhstan, Saudi Arabia, Thailand, Philippines, Ukraine, Georgia


Human development index l.jpg
Human Development Index requirements and resources

  • List of 174 countries

  • Last 24 in Africa

  • First African is Lybia at 72

  • Almost all below India, at 128, are African


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Human Poverty Index (HP-1) requirements and resources

  • 7 Latin American countries in 10 better

  • Mexico 12th, Brazil 21st, with Lybia, Philippines

  • Of 85 countries, 9 of 35 poorest are not African

  • Most Latin American and Caribbean are in the 92 countries with Medium Human Development in the 2000 report; Haiti is in Low

  • Of the countries listed 46 are High and 38 are Low Human Development


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Lack of access to health care requirements and resources

  • No data for Brazil or many Latin American and Caribbean countries

  • Number extrapolated from mean of 97 is 25% without access to health care

  • May be a rough estimate


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Rate of comsumption of richest over poorest 20% requirements and resources

Between 16-25 most countries

5.2 in Korea

3-5 in high developement

10 in USA and Australia

High development nations developing at 1-3% a year

Medium are zero or just below

50% of Low are negative

Distribution of wealth - Development


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What is the social pyramid like in Latin America? requirements and resources(www.fao.org, 2000 report, relative to 1998) There are 863 million undernourished in the world, 729 million in developing and 34 million in developed countries

  • Use the undernourished to define the poor in Latin America

  • 20% in Central America

  • 30% in Caribbean

  • 10% in South America

  • Similar to 1992 (1988-90), average 13%, 59 million total


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Depth of hunger (FAO, 2000) requirements and resourcesPer peson food deficit, in kcal

  • In Subsaharan Africa, in 46% of the countries the undernourished lack > 300kcal per day

  • In LA/Caribbean: 8% of the countries >300kcal, 65% between 200-300kcal; 25% < 200kcal

  • Some 15% of Latin Americans and Caribbeans will be called “The very poor”

  • 15% of the total population

  • Forest, mountains, seaside, riverside, semi-urbanized

  • Survive on less than US$ 70 /month


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The poor and the wealthy in Latin America and the Caribbean requirements and resources

  • The poor are 25% of the total, families living with US$ 70-350/ month

    • one sallary of US$ 250 or various US$ 100

    • 50% are urban

  • The wealthy are 1-15% of the total, more than US$ 2000 per family per month


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The middle classes requirements and resources

  • 40-50% of the population

  • US$ 400-2000 per month per family

  • Typically US$ 10000 per year

  • Secondary education

  • industrial or service sector workers, secretaries, drivers, receptionists, health and public sector workers, school teachers, university teachers, independent professional wrokers


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Epilepsy care: the very poor: 15% requirements and resources

  • Similar to central Africa except for war and famines; environment far less hostile

  • High birth and death rates; low HIV (1%)

  • Rare visiting physicians; X-rays; EEGs

  • Treatment gap universal

  • Phenobarbitone, irregular

  • Numbers increasing or decreasing?


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Epilepsy care: the poor: 25% requirements and resources

  • Irregular visits to GPs in national health system clinics

  • Catchment areas of universities: widespread in Costa Rica, Uruguay, Chile and Argentina

  • Goodwill and influence; quality decreasing

  • Rule is 20min EEG, plain X-ray, CT

  • Epilepsy surgery in +- 10 centers: Mexico, Colombia, Chile, Argentina and Brasil

  • Treatment gap 30-50%; irregular in 90%; government supplied phenobarbitone, phenytoin and benzodiazepines


Epilepsy care the wealthy 1 15 l.jpg
Epilepsy care: the wealthy: 1-15% requirements and resources

  • Private health plans: US$100/ person/month: 30% of Curitiba

  • National health rarely

  • International level hospitals in Bogotá, São Paulo, Buenos Aires, Mexico City

  • Epilepsy surgery and associated diagnosis

  • Treatment gap 20%; irregular in 50% (compliance)


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Epilepsy care: the middle class: 50% requirements and resources

  • Cultural adaptation to modern life: private health plans

  • Between US$ 20-100/ person/month: 50% of Curitiba

  • national health for major problems in cheaper plans or in default

  • Very rapid evaluations, lots of exams

  • Epilepsy surgery and associated diagnosis

  • Treatment gap 20%; irregular in 50% (psychiatric)

  • benzodiazepines


Epilepsy care in latin america l.jpg
Epilepsy care in Latin America requirements and resources

  • Epileptologists in every major city, child or adult neurologists, neurophysiologists

  • Residential centers do not exist? Large psychiatric institutions? Early death?

  • Surgery and diagnostic centers: Mexico City, Barranquilla, Santiago, Buenos Aires, São Paulo, Goiânia, Porto Alegre, Curitiba, Ribeirão Preto, Campinas

  • Too many in São Paulo, Curitiba, Goiânia

  • New drugs all available, some through public systems similar to HIV and MS


What is irrational in latin america and the caribbean aed l.jpg

Widespread use of drugs to which tolerance develops requirements and resources

Phenobarbitone, clonazepam and clobazam are cheap and tremendously easy to start

Slow deveelopment of knowledge in clinical pharmacology

Generics versus “similars”

Kinetics of phenytoin, carbamazepine

Dynamics of valproate

What is irrational in Latin America and the Caribbean (AED!)


The new reality health management organizations l.jpg

Low pay, large numbers, no time for history or orientation, one visit per month, useless EEGs

No diagnosis of age related idiopathic epilepsies

Potential failures

Diagnosis of partial seizure

kinetics

Action

Phenobarbitone in simple cases

Benzos in complex, spike-wave/ absence cases

The new reality: Health Management Organizations


What is irrational l.jpg

Barbiturates and benzos one visit per month, useless EEGs

Tonic clonic seizures

Frequent status

Somnolonce

Low IQ

Depression

New drugs

Polytherapy

Compliance

What is irrational


Conclusions l.jpg
Conclusions one visit per month, useless EEGs

  • Region covers spectrum from Subsaharan Africa to New York

  • Increasing presence of private health plans in spite of lack of progress

  • Poor clinical pharmacology and therapeutics

  • Treatment gap related to social and geographic factors


Actions ilae and ibe l.jpg
Actions: ILAE and IBE one visit per month, useless EEGs

  • ILAE: politically correct diagnosis and treatment guidelines: CT, carbamazepine and valproate rather than MRI and topiramate

  • Develop relationship with local NGOs, raising technical awareness not related to new drugs

  • NGOs to relate to local manufacturers, mainstream and of generics:

    • Distribution of cost-effective therapies

    • Local clinical pharmacology


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