Pxi based magnetic imaging system for diagnosing infant brain activity
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PXI-Based Magnetic Imaging System for Diagnosing Infant Brain Activity. Tristan Technologies, Inc., San Diego, CA. babySQUID ® Neonatal Biomagnetometer. S uperconducting QU antum I nterference D evice. Competing Methodologies. Adult Magnetoencephalography (MEG)

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PXI-Based Magnetic Imaging System for Diagnosing Infant Brain Activity

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PXI-Based Magnetic Imaging System for Diagnosing Infant Brain Activity

Tristan Technologies, Inc., San Diego, CA


babySQUID® Neonatal Biomagnetometer

Superconducting

QUantum

Interference

Device


Competing Methodologies

  • Adult Magnetoencephalography (MEG)

    • Multi-million dollar systems requiring

      large magnetically shielded rooms

    • Poorer spatial resolution

  • fMRI

    • Not truly “functional”

    • Poor time resolution

    • Requires infants to be sedated

    • Contrast agents often needed

  • PET

    • Requires administration of radioisotopes

      may not be possible with infants

    • Poor time resolution

  • EEG

    • Lack of unique source location

    • Electrodes must be placed on skull (time consuming)


A new way to evaluate neurological impairments of infants by magnetic mapping

  • 100% non-invasive MEG

    (MagnetoEncephaloGraphy)

  • Directly measures neural activity

  • Portable – goes from hospital elevator to bedside

  • Needs NO shielded room


Data Acquisition System

  • 24 bit resolution

  • 10 kSample/sec sampling rate, simultaneous

  • 88 data channels, expandable

  • Both hardware and software buffered

  • Fiber optic data link

  • Multi-PXI configuration currently being developed


babySQUID® User Interface


babySQUID® User Interface

  • Sensor Positioning

  • Incoming Data

    • Live, Playback, & Simulation

    • Filters & Filter editors

    • Monitoring Displays

  • Data Averaging

    • Artifact Rejection

    • Filters & Filter editors

    • Monitoring Displays


babySQUID® User Interface

  • Sensor Positioning

  • Incoming Data

    • Live, Playback, & Simulation

    • Filters & Filter editors

    • Monitoring Displays

  • Data Averaging

    • Artifact Rejection

    • Filters & Filter editors

    • Monitoring Displays


RealTime

Head

Tracking

Zoom

Pan

Rotate


RealTime

Head

Tracking

Zoom

Pan

Rotate


RealTime

Head

Tracking

Zoom

Pan

Rotate


RealTime

Head

Tracking

Zoom

Pan

Rotate


RealTime

Head

Tracking

Zoom

Pan

Rotate


RealTime

Head

Tracking

Zoom

Pan

Rotate


RealTime

Head

Tracking

Zoom

Pan

Rotate


RealTime

Head

Tracking

Zoom

Pan

Rotate


RealTime

Head

Tracking

Zoom

Pan

Rotate


Simulated Field

Projected onto

Skin Surface


Simulated Field

Projected onto

Skin Surface


Simulated Field

Projected onto

Skin Surface


Simulated Field

Projected onto

Skin Surface


babySQUID® User Interface

  • Sensor Positioning

  • Incoming Data

    • Live, Playback, & Simulation

    • Filters & Filter editors

    • Monitoring Displays

  • Data Averaging

    • Artifact Rejection

    • Filters & Filter editors

    • Monitoring Displays


babySQUID® User Interface

  • Sensor Positioning

  • Incoming Data

    • Live, Playback, & Simulation

    • Filters & Filter editors

    • Monitoring Displays

  • Data Averaging

    • Artifact Rejection

    • Filters & Filter editors

    • Monitoring Displays


Averaged

Data

Incoming

Data


Averaged

Data

Incoming

Data


Averaged

Data

Incoming

Data


Averaged

Data

Incoming

Data


Averaged

Data

Incoming

Data


Averaged

Data

Incoming

Data


Averaged

Data

Incoming

Data


Averaged

Data

Incoming

Data


Averaged

Data

Incoming

Data


Averaged

Data

Incoming

Data


Averaged

Data

Incoming

Data


Averaged

Data

Incoming

Data


babySQUID® User Interface

  • Sensor Positioning

  • Incoming Data

    • Live, Playback, & Simulation

    • Filters & Filter editors

    • Monitoring Displays

  • Data Averaging

    • Artifact Rejection

    • Filters & Filter editors

    • Monitoring Displays


babySQUID® User Interface

  • Sensor Positioning

  • Incoming Data

    • Live, Playback, & Simulation

    • Filters & Filter editors

    • Monitoring Displays

  • Data Averaging

    • Artifact Rejection

    • Filters & Filter editors

    • Monitoring Displays


  • Live

  • PlayBack

  • Simulation

Selectable

Data Source


Just turn the knob!


babySQUID® User Interface

  • Sensor Positioning

  • Incoming Data

    • Live, Playback, & Simulation

    • Filters & Filter editors

    • Monitoring Displays

  • Data Averaging

    • Artifact Rejection

    • Filters & Filter editors

    • Monitoring Displays


babySQUID® User Interface

  • Sensor Positioning

  • Incoming Data

    • Live, Playback, & Simulation

    • Filters & Filter editors

    • Monitoring Displays

  • Data Averaging

    • Artifact Rejection

    • Filters & Filter editors

    • Monitoring Displays


Many

Data

Displays

Sub-panels allow dynamic loading

  • Scope

  • Correlation

  • Intensity

  • Linear

  • Butterfly

  • Time-Freq

  • Surface

  • User-Defined


babySQUID® User Interface

  • Sensor Positioning

  • Incoming Data

    • Live, Playback, & Simulation

    • Filters & Filter editors

    • Monitoring Displays

  • Data Averaging

    • Artifact Rejection

    • Filters & Filter editors

    • Monitoring Displays


babySQUID® User Interface

  • Sensor Positioning

  • Incoming Data

    • Live, Playback, & Simulation

    • Filters & Filter editors

    • Monitoring Displays

  • Data Averaging

    • Artifact Rejection

    • Filters & Filter editors

    • Monitoring Displays


Multiple

Stackable

Filters

Sub-panels allow dynamic loading

  • FIR/IIR filters

  • Decimation

  • Spectrogram

  • Wavelet

  • Ref. Chan. Corr.

  • User-defined


ReferenceChannelCorrelation

Removes

distant

noise

sources


SpectrogramMask

Frequency

vs

Time

Threshold

Mask


SpectrogramMask

Frequency

vs

Time

Threshold

Mask


SpectrogramMask

Frequency

vs

Time

Threshold

Mask


SpectrogramMask

Frequency

vs

Time

Threshold

Mask


SpectrogramMask

Frequency

vs

Time

Block

Cursor


SpectrogramMask

Frequency

vs

Time

Block

Cursor


SpectrogramMask

Frequency

vs

Time

Block

Cursor


SpectrogramMask

Frequency

vs

Time

Block

Cursor


SpectrogramMask

Frequency

vs

Time

Block

Cursor


SpectrogramMask

Frequency

vs

Time

Block

Cursor


SpectrogramMask

Frequency

vs

Time

Block

Cursor


Wavelets extract hidden signals


NoiseAnalysis


Averaging of Repetitive Stimulus Data

  • Incoming data from N trigger channels is compared to a set of Boolean Templates for event detection

  • If a match is found, data in the vicinity of the match is added to an Averaging Bin

  • 10 independent Templates and Averaging Bins are available

  • Artifact Rejection algorithms


Template Comparison

Trigger 1 must have

an event in here

Trigger 2 must have

an event in here

Trigger 4 must NOT have

an event in here


AveragedLinearDisplay


AveragedLinearDisplay


AveragedLinearDisplay


AveragedLinearDisplay


AveragedLinearDisplay


AveragedLinearDisplay


AveragedLinearDisplay


Handy for multiple

monitor hardware!

Release/Dock Panels


Handy for multiple

monitor hardware!

Release/Dock Panels


Handy for multiple

monitor hardware!

Release/Dock Panels


Handy for multiple

monitor hardware!

Release/Dock Panels


Handy for multiple

monitor hardware!

Release/Dock Panels


Frequency

vs

Time

Gabor

Adaptive

Cone-

Shaped

Choi-

Williams

Wigner-

Ville

STFT


Frequency

vs

Time

Gabor

Adaptive

Cone-

Shaped

Choi-

Williams

Wigner-

Ville

STFT


Frequency

vs

Time

Gabor

Adaptive

Cone-

Shaped

Choi-

Williams

Wigner-

Ville

STFT


AveragedSurfaceDisplay

Moving time

slice across

channels


AveragedSurfaceDisplay

Moving time

slice across

channels


AveragedSurfaceDisplay

Moving time

slice across

channels


AveragedSurfaceDisplay

Moving time

slice across

channels


AveragedSurfaceDisplay

Moving time

slice across

channels


AveragedSurfaceDisplay

Moving time

slice across

channels


AveragedSurfaceDisplay

Moving time

slice across

channels


AveragedSurfaceDisplay

Moving time

slice across

channels


AveragedSurfaceDisplay

Moving time

slice across

channels


AveragedSurfaceDisplay

Moving time

slice across

channels


AveragedSurfaceDisplay

Moving time

slice across

channels


AveragedSurfaceDisplay

Moving time

slice across

channels


AveragedSurfaceDisplay

Moving time

slice across

channels


AveragedSurfaceDisplay

Moving time

slice across

channels


Current Vectormap

Simulated

Data


Signal from 6 mo. Infant in Unshielded Hospital Environment

150 ms

400 fT


Forearm stimulated by electrical stimulus at median nerve

Peripheral Nerve – Adult Data

Sensor layout display

Neural signal has moved by 5 cm in 2 msec

(first peak is the stimulus artifact)

Physical location of arm


User can adapt software to:

  • Any sensor configuration

  • Any number of sensors

  • Any sensor type (MEG, EEG, etc.) or combination (plus user-defined types)

  • Speeds up to 102 KiloSamples/sec simultaneously


  • Additional features

  • Automated system log

  • Compatible with BESA and EMSE

  • Subject and Project databases

  • Available for

    • Unix, Linux, Windows, Mac, RT

  • National languages can be loaded


  • Neonatal neurological disorders cost society billions of dollars,

    e.g. cerebral palsy & epilepsy

  • Magnetic measurements are the only way to diagnose infant brain activity, and no shielded room makes it affordable

  • Neurological medication can be directly evaluated

Supported by NIH SBIR Grant # 5 R4 NS038806-04


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