pxi based magnetic imaging system for diagnosing infant brain activity
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PXI-Based Magnetic Imaging System for Diagnosing Infant Brain Activity. Tristan Technologies, Inc., San Diego, CA . babySQUID ® Neonatal Biomagnetometer. S uperconducting QU antum I nterference D evice. Competing Methodologies. Adult Magnetoencephalography (MEG)

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pxi based magnetic imaging system for diagnosing infant brain activity

PXI-Based Magnetic Imaging System for Diagnosing Infant Brain Activity

Tristan Technologies, Inc., San Diego, CA

babysquid neonatal biomagnetometer
babySQUID® Neonatal Biomagnetometer

Superconducting

QUantum

Interference

Device

competing methodologies
Competing Methodologies
  • Adult Magnetoencephalography (MEG)
    • Multi-million dollar systems requiring

large magnetically shielded rooms

    • Poorer spatial resolution
  • fMRI
    • Not truly “functional”
    • Poor time resolution
    • Requires infants to be sedated
    • Contrast agents often needed
  • PET
    • Requires administration of radioisotopes

may not be possible with infants

    • Poor time resolution
  • EEG
    • Lack of unique source location
    • Electrodes must be placed on skull (time consuming)
slide4
A new way to evaluate neurological impairments of infants by magnetic mapping
  • 100% non-invasive MEG

(MagnetoEncephaloGraphy)

  • Directly measures neural activity
  • Portable – goes from hospital elevator to bedside
  • Needs NO shielded room
data acquisition system
Data Acquisition System
  • 24 bit resolution
  • 10 kSample/sec sampling rate, simultaneous
  • 88 data channels, expandable
  • Both hardware and software buffered
  • Fiber optic data link
  • Multi-PXI configuration currently being developed
babysquid user interface
babySQUID® User Interface
  • Sensor Positioning
  • Incoming Data
    • Live, Playback, & Simulation
    • Filters & Filter editors
    • Monitoring Displays
  • Data Averaging
    • Artifact Rejection
    • Filters & Filter editors
    • Monitoring Displays
babysquid user interface8
babySQUID® User Interface
  • Sensor Positioning
  • Incoming Data
    • Live, Playback, & Simulation
    • Filters & Filter editors
    • Monitoring Displays
  • Data Averaging
    • Artifact Rejection
    • Filters & Filter editors
    • Monitoring Displays
slide9

RealTime

Head

Tracking

Zoom

Pan

Rotate

slide10

RealTime

Head

Tracking

Zoom

Pan

Rotate

slide11

RealTime

Head

Tracking

Zoom

Pan

Rotate

slide12

RealTime

Head

Tracking

Zoom

Pan

Rotate

slide13

RealTime

Head

Tracking

Zoom

Pan

Rotate

slide14

RealTime

Head

Tracking

Zoom

Pan

Rotate

slide15

RealTime

Head

Tracking

Zoom

Pan

Rotate

slide16

RealTime

Head

Tracking

Zoom

Pan

Rotate

slide17

RealTime

Head

Tracking

Zoom

Pan

Rotate

slide18

Simulated Field

Projected onto

Skin Surface

slide19

Simulated Field

Projected onto

Skin Surface

slide20

Simulated Field

Projected onto

Skin Surface

slide21

Simulated Field

Projected onto

Skin Surface

babysquid user interface22
babySQUID® User Interface
  • Sensor Positioning
  • Incoming Data
    • Live, Playback, & Simulation
    • Filters & Filter editors
    • Monitoring Displays
  • Data Averaging
    • Artifact Rejection
    • Filters & Filter editors
    • Monitoring Displays
babysquid user interface23
babySQUID® User Interface
  • Sensor Positioning
  • Incoming Data
    • Live, Playback, & Simulation
    • Filters & Filter editors
    • Monitoring Displays
  • Data Averaging
    • Artifact Rejection
    • Filters & Filter editors
    • Monitoring Displays
slide24

Averaged

Data

Incoming

Data

slide25

Averaged

Data

Incoming

Data

slide26

Averaged

Data

Incoming

Data

slide27

Averaged

Data

Incoming

Data

slide28

Averaged

Data

Incoming

Data

slide29

Averaged

Data

Incoming

Data

slide30

Averaged

Data

Incoming

Data

slide31

Averaged

Data

Incoming

Data

slide32

Averaged

Data

Incoming

Data

slide33

Averaged

Data

Incoming

Data

slide34

Averaged

Data

Incoming

Data

slide35

Averaged

Data

Incoming

Data

babysquid user interface36
babySQUID® User Interface
  • Sensor Positioning
  • Incoming Data
    • Live, Playback, & Simulation
    • Filters & Filter editors
    • Monitoring Displays
  • Data Averaging
    • Artifact Rejection
    • Filters & Filter editors
    • Monitoring Displays
babysquid user interface37
babySQUID® User Interface
  • Sensor Positioning
  • Incoming Data
    • Live, Playback, & Simulation
    • Filters & Filter editors
    • Monitoring Displays
  • Data Averaging
    • Artifact Rejection
    • Filters & Filter editors
    • Monitoring Displays
slide38

Live

  • PlayBack
  • Simulation

Selectable

Data Source

babysquid user interface40
babySQUID® User Interface
  • Sensor Positioning
  • Incoming Data
    • Live, Playback, & Simulation
    • Filters & Filter editors
    • Monitoring Displays
  • Data Averaging
    • Artifact Rejection
    • Filters & Filter editors
    • Monitoring Displays
babysquid user interface41
babySQUID® User Interface
  • Sensor Positioning
  • Incoming Data
    • Live, Playback, & Simulation
    • Filters & Filter editors
    • Monitoring Displays
  • Data Averaging
    • Artifact Rejection
    • Filters & Filter editors
    • Monitoring Displays
slide42

Many

Data

Displays

Sub-panels allow dynamic loading

  • Scope
  • Correlation
  • Intensity
  • Linear
  • Butterfly
  • Time-Freq
  • Surface
  • User-Defined
babysquid user interface43
babySQUID® User Interface
  • Sensor Positioning
  • Incoming Data
    • Live, Playback, & Simulation
    • Filters & Filter editors
    • Monitoring Displays
  • Data Averaging
    • Artifact Rejection
    • Filters & Filter editors
    • Monitoring Displays
babysquid user interface44
babySQUID® User Interface
  • Sensor Positioning
  • Incoming Data
    • Live, Playback, & Simulation
    • Filters & Filter editors
    • Monitoring Displays
  • Data Averaging
    • Artifact Rejection
    • Filters & Filter editors
    • Monitoring Displays
slide45

Multiple

Stackable

Filters

Sub-panels allow dynamic loading

  • FIR/IIR filters
  • Decimation
  • Spectrogram
  • Wavelet
  • Ref. Chan. Corr.
  • User-defined
reference channel correlation
ReferenceChannelCorrelation

Removes

distant

noise

sources

spectrogram mask
SpectrogramMask

Frequency

vs

Time

Threshold

Mask

spectrogram mask48
SpectrogramMask

Frequency

vs

Time

Threshold

Mask

spectrogram mask49
SpectrogramMask

Frequency

vs

Time

Threshold

Mask

spectrogram mask50
SpectrogramMask

Frequency

vs

Time

Threshold

Mask

spectrogram mask51
SpectrogramMask

Frequency

vs

Time

Block

Cursor

spectrogram mask52
SpectrogramMask

Frequency

vs

Time

Block

Cursor

spectrogram mask53
SpectrogramMask

Frequency

vs

Time

Block

Cursor

spectrogram mask54
SpectrogramMask

Frequency

vs

Time

Block

Cursor

spectrogram mask55
SpectrogramMask

Frequency

vs

Time

Block

Cursor

spectrogram mask56
SpectrogramMask

Frequency

vs

Time

Block

Cursor

spectrogram mask57
SpectrogramMask

Frequency

vs

Time

Block

Cursor

averaging of repetitive stimulus data
Averaging of Repetitive Stimulus Data
  • Incoming data from N trigger channels is compared to a set of Boolean Templates for event detection
  • If a match is found, data in the vicinity of the match is added to an Averaging Bin
  • 10 independent Templates and Averaging Bins are available
  • Artifact Rejection algorithms
template comparison
Template Comparison

Trigger 1 must have

an event in here

Trigger 2 must have

an event in here

Trigger 4 must NOT have

an event in here

slide74

Frequency

vs

Time

Gabor

Adaptive

Cone-

Shaped

Choi-

Williams

Wigner-

Ville

STFT

slide75

Frequency

vs

Time

Gabor

Adaptive

Cone-

Shaped

Choi-

Williams

Wigner-

Ville

STFT

slide76

Frequency

vs

Time

Gabor

Adaptive

Cone-

Shaped

Choi-

Williams

Wigner-

Ville

STFT

averaged surface display
AveragedSurfaceDisplay

Moving time

slice across

channels

averaged surface display78
AveragedSurfaceDisplay

Moving time

slice across

channels

averaged surface display79
AveragedSurfaceDisplay

Moving time

slice across

channels

averaged surface display80
AveragedSurfaceDisplay

Moving time

slice across

channels

averaged surface display81
AveragedSurfaceDisplay

Moving time

slice across

channels

averaged surface display82
AveragedSurfaceDisplay

Moving time

slice across

channels

averaged surface display83
AveragedSurfaceDisplay

Moving time

slice across

channels

averaged surface display84
AveragedSurfaceDisplay

Moving time

slice across

channels

averaged surface display85
AveragedSurfaceDisplay

Moving time

slice across

channels

averaged surface display86
AveragedSurfaceDisplay

Moving time

slice across

channels

averaged surface display87
AveragedSurfaceDisplay

Moving time

slice across

channels

averaged surface display88
AveragedSurfaceDisplay

Moving time

slice across

channels

averaged surface display89
AveragedSurfaceDisplay

Moving time

slice across

channels

averaged surface display90
AveragedSurfaceDisplay

Moving time

slice across

channels

current vector map
Current Vectormap

Simulated

Data

peripheral nerve adult data
Forearm stimulated by electrical stimulus at median nervePeripheral Nerve – Adult Data

Sensor layout display

Neural signal has moved by 5 cm in 2 msec

(first peak is the stimulus artifact)

Physical location of arm

slide94
User can adapt software to:
  • Any sensor configuration
  • Any number of sensors
  • Any sensor type (MEG, EEG, etc.) or combination (plus user-defined types)
  • Speeds up to 102 KiloSamples/sec simultaneously
slide95

Additional features

  • Automated system log
  • Compatible with BESA and EMSE
  • Subject and Project databases
  • Available for
    • Unix, Linux, Windows, Mac, RT
  • National languages can be loaded
slide96
Neonatal neurological disorders cost society billions of dollars,

e.g. cerebral palsy & epilepsy

  • Magnetic measurements are the only way to diagnose infant brain activity, and no shielded room makes it affordable
  • Neurological medication can be directly evaluated

Supported by NIH SBIR Grant # 5 R4 NS038806-04

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