lecture 18 humoral immune response
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Lecture 18 Humoral Immune Response

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Lecture 18 Humoral Immune Response. The Antibody Response. Antibody Protection of the Host. Immunologic Memory. Virgin lymphocyte pool . PRIMARY RESPONSE . effector cells . memory cell pool . SECONDARY RESPONSE. effector cells . memory cell pool . Immunologically Naive.

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Presentation Transcript
immunologic memory
Immunologic Memory

Virgin lymphocyte pool

PRIMARY RESPONSE

effector cells

memory cell pool

SECONDARY RESPONSE

effector cells

memory cell pool

immunologically naive
Immunologically Naive

No previous experience

No memory

Must be educated

the primary immune response
The Primary Immune Response

antibody titer

lag

log phase

plateau

decline

time

antigen challenge

class switching
Class Switching

antibdy titer

IgM

IgG

time

four phases of the primary response
Four phases of the primary response
  • a lag phase where no antibody is detected
  • a log phase in which the antibody titer rises logarithmically
  • a plateau phase during which the antibody titer stabilizes
  • a phase (decline) during which the antibody is cleared or catabilized
the anamnestic immune response
The Anamnestic Immune Response

Secondary Response

antibody titer

1000

100

Primary Response

10

1

Time

comparison of primary and secondary responses
Comparison of Primary and Secondary Responses
  • Time course
  • Antibody titer
  • Antibody class
  • Antibody affinity
terms to remember
Terms to remember
  • Opsonization
  • Neutralization
  • Complement activation
  • Primary response
  • Secondary/ anamnestic/ booster response
  • Lag phase
  • Log phase
  • Plateau period
  • Memory cells
  • Class switching
  • Affinity maturation/ change in affinity with time
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