Use of Genetic Markers in Terminal Sire Sheep Sire Reference Schemes - PowerPoint PPT Presentation

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Use of Genetic Markers in Terminal Sire Sheep Sire Reference Schemes. Grant Walling, Geoff Simm, Peter Visscher & Steve Bishop. Aims. Detect genetic markers associated with performance in Suffolk, Texel and Charollais SRSs Detailed investigation of specific genes

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Use of Genetic Markers in Terminal Sire Sheep Sire Reference Schemes

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Use of genetic markers in terminal sire sheep sire reference schemes l.jpg

Use of Genetic Markers in Terminal Sire Sheep Sire Reference Schemes

Grant Walling, Geoff Simm, Peter Visscher & Steve Bishop


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Aims

  • Detect genetic markers associated with performance in Suffolk, Texel and Charollais SRSs

  • Detailed investigation of specific genes

  • Investigate strategies to use genetic markers in sire reference schemes


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Data Collection

  • Blood from commercial SRS farms

  • Performance data from Signet


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Blood Processing

  • DNA extracted from blood

  • DNA sent for genotyping on selected chromosomes


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Sheep ChromosomesCurrent Knowledge

2 contains a double muscling gene responsible for the extreme muscling in Belgian Blue cattle

4 contains the Leptin gene controlling fat deposition and appetite in the sheep

13 contains a gene controlling scrapie susceptibility

18 contains Callipyge and Carwell genes affecting muscle development

20 contains the MHC region controlling the immune response of the sheep

XY determine sex XY=Male XX=Female


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Segregation of a major gene affecting body size

X

AB

CC

BC

AC

AC

BC

Progeny receiving the A allele from their sire are on average larger than those receiving the B allele


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Data Analysis

  • Complex statistics test for evidence of genes

  • Applied to sires with large numbers of progeny


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Texels

Chromosome 2 muscle & fat

Chromosome 18 muscle

Suffolks

Chromosome 1 muscle

Chromosome 18 growth

Results

Chromosome 18 results suggest segregation of the Carwell (rib-eye muscling) gene in UK SRS flocks


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Future Work

  • Extend to Charollais Sires

  • Detailed investigations of current findings

  • Study the best way of using the findings in SRS


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Sponsors & Collaborators

Visit: http://www.ri.bbsrc.ac.uk/sheepmap


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