Multipurpose prevention technologies what are they why do we need them
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Multipurpose Prevention Technologies What are they & why do we need them?. [Presenter name, degree, affiliation] [Event title]. [Date]. Multipurpose Prevention Technologies for Reproductive Health. What do women want and need?. Every year. 80 million unintended pregnancies

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Multipurpose prevention technologies what are they why do we need them

Multipurpose Prevention TechnologiesWhat are they & why do we need them?

[Presenter name, degree, affiliation]

[Event title]

[Date]


Multipurpose prevention technologies for reproductive health
Multipurpose Prevention Technologies for Reproductive Health

What do women want and need?


Every year
Every year. . .

  • 80 million unintended pregnancies

  • 358,000 women die from pregnancy- related complications

  • 2.5 million people infected with HIV

  • 340 million new gonorrhea, syphilis, trichomonas infections

  • 250,000 deaths from cervical cancer

  • 16 % (15-49) have genital herpes (HSV-2)


Products that
products that…

Imagine

  • Prevent pregnancy, HIV/AIDS & STIs at the same time

  • Ensure women’s privacy and safety

  • Are affordable & easily available

  • Are designed by women for their specific needs & preferences




50 years of contraceptive advances
50 years of contraceptive advances

Sheldon Segal

First long term

drug delivery device

Norplant


Female controlled mpts
;Female-controlled MPTs

Female Condom

SILCS Diaphragm

Women’s Condom


Currently available mpts
Currently available MPTs

Female Condom

Male Condom


Emerging mpts
Emerging MPTs

Drug combinations

Multipurpose vaccines

Drug/device combinations

Bacterial therapeutics

Nanoparticals


Potential delivery mechanisms for mpts
Potential Delivery Mechanisms for MPTs

  • Devices

    • SILCS Diaphragm

    • Women’s Condom

  • Vaginal Rings

    • Drug release rates differ by ring type

    • Matrix rings vs. Reservoir rings

    • Release rates differ in-vitro from in-vivo

  • Vaginal Tablet

    • Combining different class ART

  • Vaginal Film

    • Nontoxic to cells and flora, fast dissolution


Multipurpose vaccines the future
Multipurpose Vaccines: the future

  • Today: Single purpose vaccines (HPV & HBV) are commercially available

  • Next 2 decades: Dual-purpose vaccines that prevent transmission of HSV, HIV, Gonorrhea, Chlamydia, Trichomonas or other STIs

  • Contraceptive vaccines not likely




Mpts in the pipeline
MPTs in the Pipeline

Mapping Matrix: www.cami-health.org


Cami activities
CAMI Activities

  • MPT Think Tank (May 2011)

  • Target Product Profile working groups (May – Oct 2011)

  • ARHP Conference (September 2011)

  • APHA Conference (October 2011)

  • International MPT Symposium, DC (November 2011)

  • International MPT Symposium, London (January 2012)

  • Microbicides 2012 Conference, Sydney (April 2012)

  • NEXT STEPS


Future directions and priorities
Future directions and priorities

  • Support and coordinate novel approaches for multi-disciplinary collaboration

  • Facilitate funding for research & development

  • Expand global and US support

  • Refine priority Product Profiles

  • Assist with clarifying the regulatory pathways


Questions
Questions?

  • www.cami-health.org

  • www.arhp.org

  • www.phi.org


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