Who cares about Rho GTPases?. Clostridium spp. Salmonella spp. Bordetella spp. Neisseria spp. http://www.geocities.com/CapeCanaveral/3504/gallery.htm. Historical GTPase Events. 1985 – isolation of Rho = ‘ R as ho molog’
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Bordetella spp.Neisseria spp.
Type III Secretion System (TTSS) for translocation of virulence factors
Bacterial changes: transient bacterial ‘invasome’ appendages
Host cell changes: macropinocytosis for uptake of Salmonella in nonphagocytic cells
bacterial induced apoptosis in phagocytic cells.
RHO FAMILY GTPASES: Rho, Rac, Cdc42
BACTERIAL INHIBITION OF RHO PROTEINS:
-Large clostridial toxins: Toxin A, B, Lethal Toxin
-C. botulinum C3 transferase
-Salmonella SptP, Yersinia YopE
BACTERIAL ACTIVATION OF RHO PROTEINS:
-E.coli CNF1 and 2 Toxins
-Bordetella dermonecrotizing toxin (DNT)
-Salmonella SopE, Yersinia CNFY
Fig. 1. Rho GTPases are targets for bacterial virulence factors.
-is it simply to return to ‘normal’ cell function?
-or to enhance bacterial uptake?
-or to avoid non-physiologic cell environs that prevent bacterial uptake at all?