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Άπνοιες στον Ύπνο και Μεταβολικό Σύνδρομο: Η Αρχή A. Καδίτης PowerPoint PPT Presentation


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Άπνοιες στον Ύπνο και Μεταβολικό Σύνδρομο: Η Αρχή A. Καδίτης. Εργαστήριο Διαταραχών Αναπνοής στον Ύπνο Α ΄ Παιδιατρική Κλινική Πανεπιστημίου Αθηνών Νοσοκομείο Παίδων «Η Αγία Σοφία». Άπνοιες και Μεταβολικό Σύνδρομο. Ορισμός Μεταβολικού Συνδρόμου στα Παιδιά.

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Άπνοιες στον Ύπνο και Μεταβολικό Σύνδρομο: Η Αρχή A. Καδίτης

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: A.



(+) 3

  • > 75 -

  • > 95 , ,

  • > 97 mg/dL

  • HDL < 50 mg/dL

  • > 100 mg/dL (> 140 mg/dL)



-:


Mitchell RB. AT for OSA in Children: Outcome Evaluated by Pre- and Post-Operative Polysomnography. Laryngoscope 2007;117:1844-54

71% of children with postoperative OAHI < 1



Redline et al. Risk Factors for Obstructive SDB in ChildrenAJRCCM 1999; 159:1527-32

  • 399-

  • 2-18

  • AHI 10

    OR 4.59 (1.58-13.33)


Amin et al. Growth Velocity Predicts Recurrence of SDB 1 Year After AT. AJRCCM 2008;177:654-9

70 ( : 10)



Kaditis et al. Obstructive SDB and Fasting Insulin Levels in non-Obese Children.Pediatr Pulmonol 2005;40:515-23

110 children

2-13 y.o.

  • AHI 5

  • AHI < 5


de la Eva R, et al. Metabolic correlates with OSA in Obese Subjects. J Pediatr 2002; 140: 654-9


Li et al. Ambulatory BP in Children with OSA: A Community Based Study. Thorax 2009;63:803-9

306

6-13


Redline et al. Association between Metabolic Syndrome and Sleep-Disordered Breathing in Adolescents. AJRCCM 2007;176:401-8

270

13.6 0.7




Kaditis et al. Urine Levels of Catecholamines in Children with Obstructive Sleep-Disordered Breathing. Pediatr Pulmonol 2009;44:38-45

Norepinephrine (ng/mg of creatinine)

Mild hypoxemia

Moderate hypoxemia

Severe hypoxemia


Kaditis et al. Effects of AT on R-R interval and BNP Levels in children with OSA. Sleep Med 2011; In press


;

;


Verhulst et al. The effect of weight loss on SDB in obese teenagers. Obesity 2002;17:1178-83

  • 21 8.714.0

  • z-score 34.8%


Gozal et al. Metabolic Alterations in OSA among Non-obese and Obese Prepubertal Children.AJRCCM 2008


;


Goodwin et al. Incidence and Remission of SDB and Related Symptoms in 6- to 17-y.o children. J Pediatr 2010;157:57-61



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