Chapter 19. Molecular Evolution and Phylogenetics. 12 and 15 November, 2004. Overview. Comparing genome sequences has offered unprecedented insight into the nature and evolution of species. Most animals have essentially the same genes.
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Molecular Evolution and Phylogenetics
12 and 15 November, 2004
Changes in Pattern-determining Gene Expression
Misexpression of Pax6 causes abnormal eye formation.
Phenotypes of changes in pattern-expression genes
Consequences of Ubx deletion and misexpression in the mesothorax
Swapping a repressor for an activator domain makes overexpressed Ubx produce a phenotype like that of overexpressed Antp.
Functional change in the Ubx binding site
Homeotic nature of the Hoxb8 deletion mutant
A mutation in the Ubx enhancer led to altered expression of Ubx at the branchiopod - isopod split, and accounts for the presence of a maxilliped instead of a swimming limb in isopods.
Drosophila Dll is repressed by Drosophila Ubx, but not by shrimp Ubx.
Expression ob butterfly hindwings probably results from loss of Ubx binding sites.
Nonconservative FOX2p changes may account for some of the speech abilities of humans.