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Research Update: Mechanisms for Control and Regulation of the AQP-4 Network. Minh Tran LPPD Mentor: Ying Hsu Advisor: Prof. Andreas Linninger Feb. 8, 2012. Control Mechanisms applicable to protein regulation networks. Block diagram for temperature feedback control system.

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research update mechanisms for control and regulation of the aqp 4 network

Research Update:Mechanisms for Control and Regulation of the AQP-4 Network

Minh Tran

LPPD

Mentor: Ying Hsu

Advisor: Prof. Andreas Linninger

Feb. 8, 2012

control mechanisms applicable to protein regulation networks
Control Mechanisms applicable to protein regulation networks

Block diagram for temperature feedback control system

previous aqp 4 network
Previous AQP-4 Network

Jared Wedell F’11

Osmotic stress

Transcription initiation

Transcription

DNA mRNA

Translation

mRNA aquaporin channel

updated aqp 4 network implementation of control loops
Updated AQP-4 Network:implementation of control loops

Cytoplasm

PKC activator

Nucleus

Functional AQP-4

Translation

P38 MAPK stimulation by

Osmotic stress

Transcription

Translation

pre-Transcription

protein control within a cell negative feedback
Protein Control within a Cell:negative feedback

Negative Feedback

Negative Feedback

PKC activator

Transcriptional

Dynamic State

Downregulates AQP-4 mRNA

Translational

Steady State

Downregulates AQP-4 mRNA

variations of p38 can either upregulate or downregulate transcription
variations of p38 can either upregulate or downregulate transcription
  • P38 is a stress-induced osmotic pathway.
  • P38α
    • Known to phosporylate Activator Factor 1 (AP-1)
      • Activated by osmotic stress.
  • P38γ
    • Known to repress Activation Factor 1 (AP-1)
      • Strongly activated by Hypoxia (lack of oxygen)
upcoming tasks
Upcoming tasks
  • Edit Jared’s Cell Network paper
  • Perform simulations of AQP-4 Network using
    • CellDesigner
    • MATLAB
  • Input additional regulatory loops into updated AQP-4 Network.
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