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11-13 Al Rahman Al Quran

A nd the earth hath He appointed for His creatures. wherein are fruit and sheathed palm trees.husked grain and scented herb. which is it of the favours of your Lord that ye deny?. 11-13 Al Rahman Al Quran. Lipids. D igestion and Absorption. Dietary Lipids.

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11-13 Al Rahman Al Quran

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  1. And the earth hath He appointed for His creatures. wherein are fruit and sheathed palm trees.husked grain and scented herb. which is it of the favours of your Lord that ye deny? 11-13 Al Rahman Al Quran Dr Jaria Fatahia

  2. Lipids Digestion and Absorption Dr Jaria Fatahia

  3. Dietary Lipids 1.Triglycerides2.Cholesterol3.Cholesterol esters4.Phospholipids Dr Jaria Fatahia

  4. Digestion of Lipids • Enzymes • Lipases ( hydrolyze fa from triglycerides) • chain lengh • pH • Emulsification • Bile salts Dr Jaria Fatahia

  5. Differentiate between micelles & chylomicrons Dr Jaria Fatahia

  6. Emulsification of lipids occurs in : • Liver • Gall bladder • Stomach • Deudenum • Jejunum Dr Jaria Fatahia

  7. Lipases • Lingual • Gastric Short and Medium Chain FA Dr Jaria Fatahia

  8. Pancreatic Enzymes • Pancreatic lipase • Colipase • Cholesterol esterase • Phospholipase a2 • Lysophospholipase Dr Jaria Fatahia

  9. Lipases • Colipase • (activated by trypsin) • Pancreatic lipase • FA of all chain lengths • Position 1 & 3 of tg • Producing free fa & 2 mag Dr Jaria Fatahia

  10. Control of lipid digestion Cholecystokinin Secretin Dr Jaria Fatahia

  11. 2 MONOACYLGLYCEROL TRIACYLGLYCEROL Dr Jaria Fatahia

  12. Cholesterol esterase (requires bile salts) Dr Jaria Fatahia

  13. Phospholipase A2 activated by trypsin Requires bile salts PHOSPHOLIPID LYSOPHOSPHOLIPID Dr Jaria Fatahia

  14. Lysophospholipase LYSOPHOSPHOLIPID GLCERYLPHOSPHORYL BASE Dr Jaria Fatahia

  15. CCK Pancreatic enzymes Contraction of gall bladder Bile Salts ( hydrophobic and hydrophilic) Dr Jaria Fatahia

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  35. Storing fat • TG in blood (CM & VLDL) • Insulin activates LPL on vessel wall • LPL binds CM or VLDL & extracts TG • Breaks down TG into Glcerol & 3 Fas • Enter cell Dr Jaria Fatahia

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  37. ______________ C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C C-C-C _____________ _____________ C-C Krebs ATP ETS Dr Jaria Fatahia

  38. Clinical aspects lipid digestion • Alcohol excess • Obstructive jaundice • Abetalipoproteinemia • Cystic fibrosis Dr Jaria Fatahia

  39. Alcohol excess • Inflammatory process in pancreas • Proteinaceous plugs in small pancreatic ducts • back pressure injury • autodigestion of acini Dr Jaria Fatahia

  40. Alcohol excess • C/F • Steatorrhea • Treatment • Commercial preparation of pancreatic enzymes • Avoid alcohol Dr Jaria Fatahia

  41. Obstructive Jaundice • Obstruction of common bile duct • Cholestasis • Dietary fats not readily emulsified & digested Dr Jaria Fatahia

  42. Obstructive Jaundice • C/F • Jaundice • Clay colored stool • Dark urine • Fat soluble vitamin deficiency Dr Jaria Fatahia

  43. Abetalipoproteinemia • Cannot form chylomicrons or VLDL • TG accumulate in intestinal & liver cells • Blood lipoproteins low • Deficiency of fat sol vitamins & essential FA Dr Jaria Fatahia

  44. In abetalipoproteinemia following is not present in blood? HDL Chylomicrons LDL Dr Jaria Fatahia

  45. The end Dr Jaria Fatahia

  46. EXCELLENT! Dr Jaria Fatahia

  47. TRY AGAIN! Dr Jaria Fatahia

  48. SORRY! Dr Jaria Fatahia

  49. Human vs cow’s milk Human • Long chain polyunsaturated fa • Important for brain development • Pancreatic lipase & bile salts low in newborn • Lingual & gastric lipases • Acid stable lipase Cow’s • Short and medium chain FA • do not require bile salts • Not packaged in chylomicrins • enter portal blood rather than lymph • Bound to serum albumin Dr Jaria Fatahia

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