b Oxidation. Energy from Fats. Overview. Just the first part is different!. Definition. b Oxidation – fatty acids are used to make Acyl-CoA molecules and broken down in mitochondria to make Acetyl-CoA molecules, which can enter the Krebs Cycle .
Energy from Fats
Just the first part is different!
Note: 2P from ATP are utilized in this process
1. FAD+ oxidizes the bond between C2 and C3
2. Adding water results in the addition of OH to C3
3. NAD+ oxidizes that OH to a carbonyl group
4. CoA cleaves the bond between C2 and C3
Example: Palmitate (16 C)
Palmitoyl CoA + 7FAD + 7NAD + 7CoA + 7H2O 8Acetyl CoA + 7FADH2 + 7NADH + 7H+
21 ATP (by oxidative phosphorylation)
14 ATP (by oxidative phosphorylation)
72 + 16 + 8 + 21 + 14 = 131.
we used to high energy phosphate bonds (equivalent of 2 ATP) to activate palmitate to palmitoyl CoA. Therefore, the ATP yield is 129.