B oxidation
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b Oxidation. Energy from Fats. Overview. Just the first part is different!. Definition. b Oxidation – fatty acids are used to make Acyl-CoA molecules and broken down in mitochondria to make Acetyl-CoA molecules, which can enter the Krebs Cycle .

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b Oxidation

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B oxidation

b Oxidation

Energy from Fats


Overview

Overview

Just the first part is different!


Definition

Definition

  • b Oxidation – fatty acids are used to make Acyl-CoA molecules and broken down in mitochondria to make Acetyl-CoA molecules, which can enter the Krebs Cycle.

  • Acyl-CoA – temporary compound formed when coenzyme attaches to fatty acid


Step 1 activation of fatty acids by acetyl coa

Step 1: Activation of Fatty Acids by Acetyl CoA

Note: 2P from ATP are utilized in this process


Step 2 acylcoa enters the matrix

Step 2: AcylCoA Enters the Matrix


Step 3 oxidation of acylcoa

Step 3: Oxidation of AcylCoA

1. FAD+ oxidizes the bond between C2 and C3

2. Adding water results in the addition of OH to C3

3. NAD+ oxidizes that OH to a carbonyl group

4. CoA cleaves the bond between C2 and C3


Notes

Notes

  • C1 = alpha C (Ca) and C2 = beta C (Cb), hence the term beta oxidation

  • Products:

    • AcylCoA (which undergoes b oxidation again)

    • Acetyl CoA (which enters the Krebs cycle)

    • NADH and FADH2 (which are utilized by ETC)


Atp yield

Example: Palmitate (16 C)

ATP Yield

Palmitoyl CoA + 7FAD + 7NAD + 7CoA + 7H2O 8Acetyl CoA + 7FADH2 + 7NADH + 7H+


How much atp did palmitate yield

How much ATP did Palmitate yield?

  • 8 acetyl CoA enter citric acid cycle and give:

    • 24 NADH = 72 ATP (by oxidative phosphorylation)

    • 8 FADH2 = 16 ATP (by oxidative phosphorylation)

    • 8 GTP = 8 ATP

  • 7 NADH generated by beta oxidation itself =

    21 ATP (by oxidative phosphorylation)

  • 7 FADH2 generated by beta oxidation itself =

    14 ATP (by oxidative phosphorylation)

  • Total number of ATP from 1 molecule of palmitate =

    72 + 16 + 8 + 21 + 14 = 131.

  • But REMEMBER:

    we used to high energy phosphate bonds (equivalent of 2 ATP) to activate palmitate to palmitoyl CoA. Therefore, the ATP yield is 129.


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