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Immunization Update 2007 Satellite Broadcast/Webcast August 9, 2007 Rotavirus Vaccine Segment

Learn about the burden of rotavirus disease in the United States, the development of rotavirus vaccines, the history of intussusception risks, and the latest recommendations for rotavirus vaccination.

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Immunization Update 2007 Satellite Broadcast/Webcast August 9, 2007 Rotavirus Vaccine Segment

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  1. Immunization Update 2007 Satellite Broadcast/Webcast August 9, 2007 Rotavirus Vaccine Segment Graphics subject to change. This material in the public domain.

  2. Burden of Rotavirus Disease in the United States • 3 million infections every year • More than 400,000 physician visits • 200,000 emergency dept visits • 55,000-70,000 hospitalizations • 20- 60 deaths Source: MMWR 2006;55 (RR-12)

  3. Rotavirus Vaccines • Created by genetic reassortment • causes nonhuman rotavirus strains to express human rotavirus antigens on their surface • nonhuman rotaviruses have low pathogenicity for humans • replicate but do not cause disease

  4. Rotashield and Intussusception • Significantly increased risk of intussusception among infants who received Rotashield • Highest risk was observed 3-7 days after the first dose • Resulted in the vaccine being taken off the market in late 1999

  5. Rotavirus Vaccine and Intussusception Vaccine Recipients 6 cases 13 cases Placebo Recipients 5 cases 15 cases Within 42 days of vaccination Within 1 year of vaccination Source: New Eng J Med 2006;354:23-33

  6. RotaTeq Intussusception ReportsReceived by VAERS* • 117 confirmed reports • 38 cases 1-21 days after vaccination • 23 cases 1-7 days after vaccination • about one third of 38 cases occurred following the first dose • 6 million vaccine doses distributed *March 2006 through mid-June 2007

  7. Expected and Reported Cases of Intussusception After RotaTeq *Among children 6-35 weeks of age, within 21 days of a dose based on VSD data

  8. Rotavirus Vaccine Recommendations • 3 oral doses at 2, 4, and 6 months of age • Series may be started as early as 6 weeks of age • First dose should be administered between 6 and 12 weeks of age • Vaccination should NOT be initiated for infants older than 12 weeks of age • Minimum interval between subsequent doses is 4 weeks Source: MMWR 2006;55 (RR-12)

  9. Rotavirus Vaccine Recommendations • All 3 doses of vaccine should be administered by 32 weeks of age • Vaccine should NOT be administered after 32 weeks of age Source: MMWR 2006;55 (RR-12)

  10. CDC Vaccines and ImmunizationContact Information • Hotline (800) CDC-INFO • Email nipinfo@cdc.gov • Website www.cdc.gov/nip • Broadcast Updates and Resources Web Page www.cdc.gov/vaccines/ed/broadcasts.htm

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