sickle cell anemia
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Sickle-Cell Anemia. • Homozygous Dominant ( HbA , HbA ) normal hemoglobin • Homozygous Recessive ( HbS , HbS ) abnormal hemoglobin • Heterozygous ( Hb A, Hb S) normal and abnormal hemoglobin normal hemoglobin more abundant.

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sickle cell anemia
Sickle-Cell Anemia

• Homozygous Dominant (HbA, HbA)

  • normal hemoglobin

• Homozygous Recessive (HbS, HbS)

  • abnormal hemoglobin

• Heterozygous (Hb A, Hb S)

  • normal and abnormal hemoglobin
  • normal hemoglobin more abundant

Note: Hemoglobin is a protein in red blood cells carrying oxygen.

clinical signs and symptoms
Clinical Signs and Symptoms

• Pain crises

• Acute chest syndrome (a life-threatening pneumonia-like illness)

• Cerebrovascular accidents

• Splenic and renal dysfunction

• Chronic anemia

• Susceptibility to infections

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