1 / 10

Self-Assembly of Surfactant-like Peptides

Self-Assembly of Surfactant-like Peptides. Steve S. Santoso, Sylvain Vauthey & Shuguang Zhang Center for Biomedical Engineering Massachusetts Institute of Technology. Nanostructures. Structures ranging from 1 to 100 nm Sub-micrometer science and engineering that combine multiple disciplines:

edythe
Download Presentation

Self-Assembly of Surfactant-like Peptides

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Self-Assembly of Surfactant-like Peptides Steve S. Santoso, Sylvain Vauthey & Shuguang Zhang Center for Biomedical Engineering Massachusetts Institute of Technology

  2. Nanostructures • Structures ranging from 1 to 100 nm • Sub-micrometer science and engineering that combine multiple disciplines: • Chemistry • Biology • Physics • Material science • Engineering • How to build / design nanostructures? • Want the atomic selectivity of synthetic chemistry yet the expandability of engineering • Molecular self-assembly may be useful

  3. Self-assembly processes common in biological systems: • Cell membrane • Multi-component cellular machinery: ribosome • Protein folding • Self-assembly involves non-covalent bonding • van der Waals • hydrogen bonds • dipolar forces • dynamic process

  4. Surfactant-like peptides [Ac]-VVVVVVD Six hydrophobic valines (tail) One polar aspartic acid (head) 2 nm

  5. Preliminary experiments and results • Some condition screening • Use: dynamic light scattering (DLS), TEM • Found larger structures for some conditions:

  6. Cryo-TEM: 300 nm

  7. Nanotubes are not the structure with energetic global minimum:

  8. Nanovesicle RF • Controlled delivery of small chemicals • Use nanovesicle to study replication of biological • materials in an enclosed environment

  9. 150 nm 550 nm

  10. Summary • Peptide surfactants are promising substrates for advanced • material and its application. • Cost-effective • Certain structures will form under certain environmental • and chemical conditions • Tunable • Biological origin may be advantageous for medical application • A good system to study self-assembly.

More Related