Chapt. 9 Regulation of Enzymes. Regulation of Enzymes Student Learning Outcomes : Explain that enzyme activities must be regulated for proper body function Explain three general mechanisms: Reversible binding in active site: substrate, inhibitors
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Overcome by excess substrate (increase apparent Km)
Not overcome by substrate (lowers [E] and Vmax)
Products can also inhibit enzyme activity
Fig. 9.9 cAMP activates PKA
(as on Ras protein)
Fig. 6.13 modified amino acids
CaMkinasefamily activated by Ca2+/calmodulin; phosphorylate metabolic enzymes, ion channels, transcription factors, regulate synthesis, release of neurotransmitters.