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NUTRITION. A proper diet requires a balance of carbohydrates, fats, and proteins. In addition the body requires many phytochemicals, vitamins, minerals, enzymes, and water. Food Intake. Food energy measured in Calories Carbohydrates - obtained primarily through plants

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nutrition
NUTRITION
  • A proper diet requires a balance of carbohydrates, fats, and proteins. In addition the body requires many phytochemicals, vitamins, minerals, enzymes, and water.
food intake
Food Intake
  • Food energy measured in Calories
  • Carbohydrates -
    • obtained primarily through plants
    • Monosaccharides used for cellular fuel
    • Minimum carbohydrates = 100 g/day
lipids 30 of calories
Lipids < 30% of calories
  • Mostly triglycerides
  • Saturated fats usually from animals
  • Cholesterol only from animals
  • Neutral fats provide insulation and energy reserves
  • Phospholipids for membranes and myelin
  • Cholesterol for membranes, vitamin D, steroid hormones, and bile salts
proteins 0 8 g kg of body wt
Proteins = 0.8 g/kg of body wt
  • 8 Essential amino acids
  • Plants usually lack 1 or more essential amino acids / Animal protein usually contains all
  • Amino acids used to build structural proteins and enzymes
vitamins vita latin word for life
VITAMINS: "vita" = Latin word for life.
  • Vitamins are organic substances that act as coenzymes, chemicals that assist the enzymes in the bodies reactions. They do not provide energy or calories.
  • Vitamins may be either Fat Soluble or Water Soluble.
fat soluble vitamins
Fat soluble vitamins
  • are stored in the body\'s fatty tissues. Fat soluble vitamins include the vitamins
    • A
    • D
    • E
    • K.
vitamin a
Vitamin A
  • Found in fish, liver, eggs, butter, yellow & green vegetables, fruits
  • Needed for healthy skin, eyes, bones, teeth.
  • Deficiency causes night blindness, skin disorders, kidney stones
vitamin d
Vitamin D
  • Found in liver, fish, eggs, milk, sunlight
  • Needed for growth, healthy bones, metabolism of calcium & phosphorus
  • Deficiency causes rickets, poor teeth and bones.
vitamin e
Vitamin E
  • Found in whole grains, leafy vegetables, milk, butter, vegetable oils
  • Needed for healthy cell membranes, red blood cells
  • Deficiency causes red cell rupture, muscle disorders
vitamin k
Vitamin K
  • Found in leafy vegetables, soybeans, made by intestinal bacteria
  • Needed for normal blood clotting
  • Deficiency causes slow clotting, hemorrhaging.
water soluble vitamins
Water soluble vitamins
  • can be dissolved in water but cannot be stored in the tissues.
  • They must be obtained each day from food.
water soluble vitamins include
B1 (Thiamine)

B2 (Riboflavin)

Niacin

B6 (Pyridoxine)

Pantothenic Acid

Biotin

B12

Folic Acid

C (Ascorbic acid)

Water soluble vitamins include
vitamin b1 thiamine
Vitamin B1 (Thiamine)
  • Found in organ meats, whole grains, vegetables
  • Needed for proper functioning of heart, nervous system, digestion
  • Deficiency causes beriberi, cardiovascular disorders.
vitamin b2 riboflavin
Vitamin B2 (Riboflavin)
  • Found in liver, poultry, milk, eggs, cheese, fish, green vegetables, whole grain
  • Needed for metabolism of protein, carbohydrates, and fats, healthy skin
  • Used to make FAD for metabolism
  • Deficiency causes dim vision, premature aging, sore mouth
vitamin b6 pyridoxine
Vitamin B6 (Pyridoxine)
  • Found in meats, liver, whole grains, vegetables
  • Needed for sodium and phosphorus balance
  • Deficiency causes anemia, nausea, loss of appetite, nervousness
vitamin b12
Vitamin B12
  • Found in Liver, meats, eggs, cheese, dairy products
  • Needed for red cell production, healthy nervous system.
  • Deficiency causes pernicious anemia.
vitamin c
Vitamin C
  • Found in citrus and other fruits, leafy vegetables, tomatoes, potatoes
  • Needed for healthy blood vessels, resistance to infection, healing
  • Deficiency causes scurvy, bruising, bleeding gums
niacin
Niacin
  • Found in red meats, organ meats, fish, green vegetables
  • Needed for metabolism, digestion, nerves, skin
  • Used to make NAD for metabolism
  • Deficiency causes pellagra, sore mouth, diarrhea, depression
folic acid
Folic Acid
  • Found in green vegetables, liver, whole grains, legumes
  • Needed for manufacture of proteins and red blood cells, needed for cell division, helps prevent spina bifida
  • Deficiency causes inflamed tongue, diarrhea, B12 deficiency.
minerals
MINERALS:
  • Inorganic substances that are used in the chemical reactions of the body.
  • Major minerals needed include:
  • Calcium, Iodine, Iron, Magnesium, Phosphorus, Potassium, and Sodium. 
calcium
Calcium
  • Found in milk, cheese, vegetables
  • Needed for strong bones and teeth, blood clotting
iodine
Iodine
  • Found in seafoods, iodized salt
  • Needed for normal thyroid metabolism, prevents goiter
slide27
Iron
  • Found in liver, meat, eggs
  • Needed for red cell production, prevents anemia
magnesium
Magnesium
  • Found in milk, meat, whole grains, legumes
  • Needed for proper nerve and muscle functioning
phosphorus
Phosphorus
  • Found in milk, whole grains, meats, nuts, legumes
  • Needed for tooth and bone development, ATP, nucleic acids
potassium
Potassium
  • Found in whole grains, fruits, legumes, meat
  • Needed for proper nerve and muscle function
sodium
Sodium
  • Found in seafood, table salt
  • Needed for water balance, proper nerve and muscle function
free radicals
Free Radicals

charged molecules that become oxidized by combining with oxygen or the removal of hydrogen, causing electron deficiency.

seek to regain the electron by removing it from other molecules, thus oxidizing them.

set up a chain reaction that may damage cell structures such as DNA, cell membranes, or needed enzymes.

slide33
Free radicals may be produced by normal metabolic processes, the immune system in response to disease, exposure to chemicals, toxins, or radiation. Free radical generation may be increased by exercise and stress.
slide34
Damage caused by free radical generation is a major cause of the degenerative effects of aging, may cause cancers, damage to arterial walls leading to heart disease and/or stroke, and lead to other degenerative diseases such as Alzheimer’s.
antioxidants
Antioxidants

have a protective effect by neutralizing free radicals.

best known antioxidants are Vitamin C, Vitamin E, and beta carotene.

many others and possibly many yet to be discovered.

proper number, types, and balance of is an important part of nutrition.

metabolism

METABOLISM

Sum of all the chemical reactions occurring within the body

types of metabolic reactions
Types of Metabolic Reactions
  • Anabolic reactions - energy requiring synthesis reactions
  • Catabolic reactions - energy releasing reactions that generate ATP
enzymes globular proteins that act as catalysts
Enzymes - globular proteins that act as catalysts
  • Increase reaction rates
  • Holoenzyme - a two-part enzyme consisting of a protein part and an organic cofactor
    • Apoenzyme - the protein portion
    • Coenzyme - the organic cofactor; usually a vitamin
energy production
Energy Production
  • Oxidation reactions - loss of an electron by an atom or molecule
  • Reduction reactions - involves the gain of electrons by a molecule
  • Coupled redox reactions
cellular respiration

Cellular Respiration

Oxidation of Glucose

glucose metabolism
Glucose Metabolism
  • Glycolysis
  • Acetyl Coenzyme A
  • Krebs Cycle
  • Electron Transport Chain
glycolysis
Glycolysis
  • Glucose molecules are broken down into two molecules of pyruvic acid in the cytoplasm of the cell
  • Net gain of 2 molecules of ATP
  • No oxygen required
  • Fate of pyruvic acid depends on the oxygen availability
glycolysis1
Glycolysis
  • Glucose C6H12O6
  • Glucose-6-phosphate ATP
  • Fructose-6-phosphate ADP ATP
  • Fructose 1,6, diphosphate ADP
  • Glyceraldehyde-3-Phosphate or Dihydroxyacetone Phosphate
  • 2Pyruvate (pyruvic acid) + 2NAD + 4ATP
  • 2C3H4O3 + 2NADH+ + 2ATP (net)
acetyl coa formation
Acetyl CoA Formation
  • Pyruvic acid is decarboxylated by the removal of CO2 into a two carbon acetyl group
  • Occurs in the mitochondria of the cell
krebs cycle tca cycle
Krebs Cycle - TCA Cycle
  • Formation of citric acid when oxaloacetic acid combines with acetyl CoA
  • Organic molecules are broken down, carbon dioxide is released and hydrogen atoms are removed & transferred by coenzymes NAD & FAD
kreb s cycle
Kreb’s Cycle
  • Acetyl CoA + Oxalocetic Acid
  • Citric Acid
  • Isocitric Acid CO2 NADH2
  • alpha-Ketoglutaric Acid CO2 NADH2
  • Succinyl CoA ATP
  • Succinnic Acid FADH2
  • Fumaric Acid
  • Malic Acid NADH2
electron transport
Electron Transport
  • Involves electron carrier molecules that will release energy in a controlled way
  • This energy is used to generate ATP
  • Occurs inner mitochondrial membrane
  • Chemiosmosis
glucose anabolism
Glucose Anabolism
  • Glycogenesis - conversion of glucose to glycogen; stimulated by insulin
  • Glycogenolysis - hydrolysis of glycogen to form glucose; stimulated by glucagon
  • Gluconeogenesis - synthesis of glucose from non-carbohydrates such as fats and amino acids
lipid catabolism lipolysis
Lipid Catabolism - Lipolysis
  • Hydrolysis of triglycerides into glycerol and fatty acids
  • Glycerol converted to G 3-P and then into pyruvic acid, then into the Kreb’s cycle
  • Beta -oxidation of fatty acids occurs forming two-carbon fragments which is then attached to coenzyme A, forming acetyl CoA
protein metabolism
Protein Metabolism
  • Proteins are converted into substances than can enter the Kreb’s cycle by
    • deamination - loss of (NH2) from amino group
    • decarboxylation - loss of CO2 molecule
    • dehydrogenation - loss of hydrogen atom
  • Protein synthesis involves transcription and translation
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