Nutrition
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NUTRITION. A proper diet requires a balance of carbohydrates, fats, and proteins. In addition the body requires many phytochemicals, vitamins, minerals, enzymes, and water. Food Intake. Food energy measured in Calories Carbohydrates - obtained primarily through plants

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NUTRITION

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Nutrition

NUTRITION

  • A proper diet requires a balance of carbohydrates, fats, and proteins. In addition the body requires many phytochemicals, vitamins, minerals, enzymes, and water.


Food intake

Food Intake

  • Food energy measured in Calories

  • Carbohydrates -

    • obtained primarily through plants

    • Monosaccharides used for cellular fuel

    • Minimum carbohydrates = 100 g/day


Lipids 30 of calories

Lipids < 30% of calories

  • Mostly triglycerides

  • Saturated fats usually from animals

  • Cholesterol only from animals

  • Neutral fats provide insulation and energy reserves

  • Phospholipids for membranes and myelin

  • Cholesterol for membranes, vitamin D, steroid hormones, and bile salts


Proteins 0 8 g kg of body wt

Proteins = 0.8 g/kg of body wt

  • 8 Essential amino acids

  • Plants usually lack 1 or more essential amino acids / Animal protein usually contains all

  • Amino acids used to build structural proteins and enzymes


Vitamins vita latin word for life

VITAMINS: "vita" = Latin word for life.

  • Vitamins are organic substances that act as coenzymes, chemicals that assist the enzymes in the bodies reactions. They do not provide energy or calories.

  • Vitamins may be either Fat Soluble or Water Soluble.


Fat soluble vitamins

Fat soluble vitamins

  • are stored in the body's fatty tissues. Fat soluble vitamins include the vitamins

    • A

    • D

    • E

    • K.


Vitamin a

Vitamin A

  • Found in fish, liver, eggs, butter, yellow & green vegetables, fruits

  • Needed for healthy skin, eyes, bones, teeth.

  • Deficiency causes night blindness, skin disorders, kidney stones


Vitamin d

Vitamin D

  • Found in liver, fish, eggs, milk, sunlight

  • Needed for growth, healthy bones, metabolism of calcium & phosphorus

  • Deficiency causes rickets, poor teeth and bones.


Vitamin e

Vitamin E

  • Found in whole grains, leafy vegetables, milk, butter, vegetable oils

  • Needed for healthy cell membranes, red blood cells

  • Deficiency causes red cell rupture, muscle disorders


Vitamin k

Vitamin K

  • Found in leafy vegetables, soybeans, made by intestinal bacteria

  • Needed for normal blood clotting

  • Deficiency causes slow clotting, hemorrhaging.


Water soluble vitamins

Water soluble vitamins

  • can be dissolved in water but cannot be stored in the tissues.

  • They must be obtained each day from food.


Water soluble vitamins include

B1 (Thiamine)

B2 (Riboflavin)

Niacin

B6 (Pyridoxine)

Pantothenic Acid

Biotin

B12

Folic Acid

C (Ascorbic acid)

Water soluble vitamins include


Vitamin b1 thiamine

Vitamin B1 (Thiamine)

  • Found in organ meats, whole grains, vegetables

  • Needed for proper functioning of heart, nervous system, digestion

  • Deficiency causes beriberi, cardiovascular disorders.


Vitamin b2 riboflavin

Vitamin B2 (Riboflavin)

  • Found in liver, poultry, milk, eggs, cheese, fish, green vegetables, whole grain

  • Needed for metabolism of protein, carbohydrates, and fats, healthy skin

  • Used to make FAD for metabolism

  • Deficiency causes dim vision, premature aging, sore mouth


Vitamin b6 pyridoxine

Vitamin B6 (Pyridoxine)

  • Found in meats, liver, whole grains, vegetables

  • Needed for sodium and phosphorus balance

  • Deficiency causes anemia, nausea, loss of appetite, nervousness


Vitamin b12

Vitamin B12

  • Found in Liver, meats, eggs, cheese, dairy products

  • Needed for red cell production, healthy nervous system.

  • Deficiency causes pernicious anemia.


Vitamin c

Vitamin C

  • Found in citrus and other fruits, leafy vegetables, tomatoes, potatoes

  • Needed for healthy blood vessels, resistance to infection, healing

  • Deficiency causes scurvy, bruising, bleeding gums


Niacin

Niacin

  • Found in red meats, organ meats, fish, green vegetables

  • Needed for metabolism, digestion, nerves, skin

  • Used to make NAD for metabolism

  • Deficiency causes pellagra, sore mouth, diarrhea, depression


Folic acid

Folic Acid

  • Found in green vegetables, liver, whole grains, legumes

  • Needed for manufacture of proteins and red blood cells, needed for cell division, helps prevent spina bifida

  • Deficiency causes inflamed tongue, diarrhea, B12 deficiency.


Minerals

MINERALS:

  • Inorganic substances that are used in the chemical reactions of the body.

  • Major minerals needed include:

  • Calcium, Iodine, Iron, Magnesium, Phosphorus, Potassium, and Sodium. 


Calcium

Calcium

  • Found in milk, cheese, vegetables

  • Needed for strong bones and teeth, blood clotting


Iodine

Iodine

  • Found in seafoods, iodized salt

  • Needed for normal thyroid metabolism, prevents goiter


Nutrition 3146718

Iron

  • Found in liver, meat, eggs

  • Needed for red cell production, prevents anemia


Magnesium

Magnesium

  • Found in milk, meat, whole grains, legumes

  • Needed for proper nerve and muscle functioning


Phosphorus

Phosphorus

  • Found in milk, whole grains, meats, nuts, legumes

  • Needed for tooth and bone development, ATP, nucleic acids


Potassium

Potassium

  • Found in whole grains, fruits, legumes, meat

  • Needed for proper nerve and muscle function


Sodium

Sodium

  • Found in seafood, table salt

  • Needed for water balance, proper nerve and muscle function


Free radicals

Free Radicals

charged molecules that become oxidized by combining with oxygen or the removal of hydrogen, causing electron deficiency.

seek to regain the electron by removing it from other molecules, thus oxidizing them.

set up a chain reaction that may damage cell structures such as DNA, cell membranes, or needed enzymes.


Nutrition 3146718

Free radicals may be produced by normal metabolic processes, the immune system in response to disease, exposure to chemicals, toxins, or radiation. Free radical generation may be increased by exercise and stress.


Nutrition 3146718

Damage caused by free radical generation is a major cause of the degenerative effects of aging, may cause cancers, damage to arterial walls leading to heart disease and/or stroke, and lead to other degenerative diseases such as Alzheimer’s.


Antioxidants

Antioxidants

have a protective effect by neutralizing free radicals.

best known antioxidants are Vitamin C, Vitamin E, and beta carotene.

many others and possibly many yet to be discovered.

proper number, types, and balance of is an important part of nutrition.


Metabolism

METABOLISM

Sum of all the chemical reactions occurring within the body


Types of metabolic reactions

Types of Metabolic Reactions

  • Anabolic reactions - energy requiring synthesis reactions

  • Catabolic reactions - energy releasing reactions that generate ATP


Enzymes globular proteins that act as catalysts

Enzymes - globular proteins that act as catalysts

  • Increase reaction rates

  • Holoenzyme - a two-part enzyme consisting of a protein part and an organic cofactor

    • Apoenzyme - the protein portion

    • Coenzyme - the organic cofactor; usually a vitamin


Energy production

Energy Production

  • Oxidation reactions - loss of an electron by an atom or molecule

  • Reduction reactions - involves the gain of electrons by a molecule

  • Coupled redox reactions


Cellular respiration

Cellular Respiration

Oxidation of Glucose


Glucose metabolism

Glucose Metabolism

  • Glycolysis

  • Acetyl Coenzyme A

  • Krebs Cycle

  • Electron Transport Chain


Glycolysis

Glycolysis

  • Glucose molecules are broken down into two molecules of pyruvic acid in the cytoplasm of the cell

  • Net gain of 2 molecules of ATP

  • No oxygen required

  • Fate of pyruvic acid depends on the oxygen availability


Glycolysis1

Glycolysis

  • Glucose C6H12O6

  • Glucose-6-phosphate ATP

  • Fructose-6-phosphate ADP ATP

  • Fructose 1,6, diphosphate ADP

  • Glyceraldehyde-3-Phosphate or Dihydroxyacetone Phosphate

  • 2Pyruvate (pyruvic acid) + 2NAD + 4ATP

  • 2C3H4O3 + 2NADH+ + 2ATP (net)


Acetyl coa formation

Acetyl CoA Formation

  • Pyruvic acid is decarboxylated by the removal of CO2 into a two carbon acetyl group

  • Occurs in the mitochondria of the cell


Krebs cycle tca cycle

Krebs Cycle - TCA Cycle

  • Formation of citric acid when oxaloacetic acid combines with acetyl CoA

  • Organic molecules are broken down, carbon dioxide is released and hydrogen atoms are removed & transferred by coenzymes NAD & FAD


Kreb s cycle

Kreb’s Cycle

  • Acetyl CoA + Oxalocetic Acid

  • Citric Acid

  • Isocitric Acid CO2 NADH2

  • alpha-Ketoglutaric Acid CO2 NADH2

  • Succinyl CoA ATP

  • Succinnic Acid FADH2

  • Fumaric Acid

  • Malic Acid NADH2


Electron transport

Electron Transport

  • Involves electron carrier molecules that will release energy in a controlled way

  • This energy is used to generate ATP

  • Occurs inner mitochondrial membrane

  • Chemiosmosis


Glucose anabolism

Glucose Anabolism

  • Glycogenesis - conversion of glucose to glycogen; stimulated by insulin

  • Glycogenolysis - hydrolysis of glycogen to form glucose; stimulated by glucagon

  • Gluconeogenesis - synthesis of glucose from non-carbohydrates such as fats and amino acids


Lipid metabolism

Lipid Metabolism


Lipid catabolism lipolysis

Lipid Catabolism - Lipolysis

  • Hydrolysis of triglycerides into glycerol and fatty acids

  • Glycerol converted to G 3-P and then into pyruvic acid, then into the Kreb’s cycle

  • Beta -oxidation of fatty acids occurs forming two-carbon fragments which is then attached to coenzyme A, forming acetyl CoA


Protein metabolism

Protein Metabolism

  • Proteins are converted into substances than can enter the Kreb’s cycle by

    • deamination - loss of (NH2) from amino group

    • decarboxylation - loss of CO2 molecule

    • dehydrogenation - loss of hydrogen atom

  • Protein synthesis involves transcription and translation


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