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The Challenge - Open standards for drug discovery data

(IMI call-topic 8, 2010). The Challenge - Open standards for drug discovery data Drug discovery research is increasingly data and information driven but we are challenged to integrate content across domains (Chemistry, Biology, Clinical) Key content spread over many sources

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The Challenge - Open standards for drug discovery data

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  1. (IMI call-topic 8, 2010) • The Challenge - Open standards for drug discovery data • Drug discovery research is increasingly data and information driven but we are challenged to integrate content across domains (Chemistry, Biology, Clinical) • Key content spread over many sources • Lack of agreed standards and formatting drives unsustainable efforts in content integration • Increasing volumes and privacy constraints (e.g. Biobanks) drives paradigm shift: We need to move analysis to data rather than retrieve data for analysis • Open PHACTS Project (31partners: 10 pharma – 21academic / SME) • Develop robust standards for solid integration between data sources via semantic technologies • Implement the standards in a semantic integration hub (“Open Pharmacological Space”) • Deliver services to support on-going drug discovery programs in pharma and public domain • Benefit: • Reduced costs and improved access to inter-operable drug discovery information • Work on-going with RSC/Chemspider on data-models for handling drug formulations, combinations and public sources; Source most public data directly from RSC/Chemspider in correct format • Development of critical skills and organisational learning • Access to leading European labs in semantic data, workflow analysis and information mining (U Manchester, VU Amsterdam, NBIC, Frauenhofer) • Structured plan to align AZ scientists within work-packages to directly exploit developments in on-going internal initiatives www.openphacts.org

  2. Open PHACTS Project Partners University of Manchester Maastricht University Aqnowledge University of Santiago de Compostela RheinischeFriedrich-Wilhelms-UniversitätBonn AstraZeneca Pfizer Limited Esteve Novartis Merck www.openphacts.org H. Lundbeck A/S Eli Lilly Netherlands Bioinformatics Centre Swiss Institute of Bioinformatics ConnectedDiscovery EMBL-European Bioinformatics Institute Janssen Pharmaceutica OpenLink The Open PHACTS Foundation Almirall SciBite GlaxoSmithKline – Coordinator UniversitätWien – Managing entity Technical University of Denmark University of Hamburg, Center for Bioinformatics BioSolveITGmBH ConsorciMar Parc de Salut de Barcelona Leiden University Medical Centre Royal Society of Chemistry VrijeUniversiteit Amsterdam Spanish National Cancer Research Centre

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