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A comparison of 3 withdrawal scales

A comparison of 3 withdrawal scales. Jean-François ETTER, PhD Institute of social and preventive medicine University of Geneva, Switzerland John R. HUGHES, MD Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA SRNT Tuebingen, Oct. 7, 2004. Background.

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A comparison of 3 withdrawal scales

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  1. A comparison of 3 withdrawal scales Jean-François ETTER, PhD Institute of social and preventive medicine University of Geneva, Switzerland John R. HUGHES, MD Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA SRNT Tuebingen, Oct. 7, 2004

  2. Background • Valid measures of withdrawal are needed for research and treatment • Many scales are available… • …but no comparison of their performance • Which scale to choose? • Aim: to compare the validity of 3 withdrawal scales

  3. Minnesota Withdr. Form (MWF) • 1986, 8 items: • Depressed mood (sad) • Insomnia • Irritable, frustrated, angry • Anxious (nervous) • Difficulty concentrating • Restless (impatient) • Increased appetite, weight gain • Desire or Craving to smoke • + Total score MWF

  4. Wisconsin Withdr. Scale (WWS) • 1999 • 28 items, 7 subscales: • Anger • Anxiety • Concentration • Craving • Hunger • Sadness • Sleep • + Total score WWS

  5. Cigarette Withdr. Scale (CWS-21) • 2003 • 21 items, 6 subscales: • Depression-Anxiety • Craving • Irritability-Impatience • Appetite-Weight Gain • Insomnia • Difficulty Concentrating • + Total score CWS-21

  6. Methods • Internet survey (in English) on STOP-TABAC.CH • 1st follow-up after 14 days • 2nd follow-up after 42 days • Content validity: DSM-IV and ICD-10 • Factor structure: robust in bootstrap resampling? • Reliability: - Cronbach’s alpha- test-retest (0-14 days) (excluding recent quitters)

  7. Tests of predictive validity • Hypotheses: • In recent ex-smokers (have quit for <31 days):baseline withdr. scores would predict relapse- after 14 days (n = 324)- after 42 days (n = 316) • In baseline smokers who quit at 14-day retest:change scores between days 0-14 would predict relapse at day 42 (n = 34)

  8. Tests of construct validity • In 178 recent ex-smokers (quit <1 month) still abstinent at day 14, withdrawal would decrease between days 0-14 • In 27 smokers who quit between days 0 and 14, withdrawal ratings would increase between days 0-14 • In 30 ex-smokers who relapsed at retest, withdrawal would decrease between days 0-14

  9. Results: participation • N = 4644, 67% women, age = 40 • Current smokers 44% (median 20 cig./day) • Former smokers 49% (median 60 days quit) • Never smokers 7% (data not reported here) • USA=50%, Canada=10%, UK=10%, other=30% • 1st follow-up after 14 days : n = 1309 (28%) • 2nd follow-up after 42 days: n = 1431 (31%)

  10. Results: content validity • All 3 scales covered DSM-IV and ICD-10 criteria of dependence, but… • No scale covered decreased heart rate (DSM-IV) • No scale covered cough, mouth ulcers (ICD-10) • Wisconsin W. Scale did not cover weight gain

  11. Factor analysis, reliability • Factor analysis (MAP test, parallel analysis): - 6 factors in WWS, instead of expected 7 factors, Sadness + Anxiety items loaded on same factor- CWS: 6 factors, as expected- MWF: 1 factor • Cronbach's alpha (0.76 to 0.93) were high for all scales +subscales (redundancy in 5-item scales?) • Test-retest coefficients: - range 0.66-0.86 for CWS and WWS,- low for some MWF items (range 0.52-0.80)

  12. Predictive validity: baseline scores • In 324 recent ex-smokers, only craving predicted relapse at 14-day follow-up. • No scale or subscale predicted relapse at 42 days • Area under ROC curve = an accepted quantitative measure of the accuracy of a test • Relapse day 14, AUC of ROC (95% CI): • CWS craving: 0.63 (0.55-0.71) • WWS craving: 0.58 (0.51-0.66) • MWF craving: 0.64 (0.56-0.73)

  13. Predictive validity: change scores • In 34 smokers who had quit smoking by day 14, an increase in withdrawal between days 0-14 predicted relapse at day 42: Area under ROCcurve (95% CI): • Craving (MWF) 0.76 (0.56-0.97) • Depressed Mood (MWF) 0.72 (0.52-0.91) • Total score WWS 0.76 (0.58-0.94) • Craving (WWS) 0.74 (0.57-0.91) • Diff. concentrating (WWS) 0.74 (0.57-0.91)

  14. Change between days 0-14 in 178 recent quitters(had quit <1 month before baseline) T stat from paired-samples t-test CWS t = 6.7 WWS t = 8.1 MWF t = 7.8 All p<.001

  15. Construct validity • Hypothesis: withdrawal would increase post-cessation: not verified, except for appetite • Unexpected results, probably because of data collection procedure

  16. Conclusions • No scale showed a decisive advantage over the others • MWF: brief • Single items measures in MWF: lower test-retest, but good performance in construct validity tests • More sophisticated tests might show that multi-item scales do better • Craving: performed best, but not in DSM-IV • Further comparisons needed with- Shiffman-Jarvik Scale- Smoker’s Complaint Scale - Mood and Physical Symptoms Scale (MPSS)

  17. Acknowledgements • No external funding • Vincent Baujard, from HON foundation (www.hon.ch), developed the software for data collection

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